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Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies

Biotechnology and bioengineering, 2012-12, Vol.109 (12), p.3172-3181

2012

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Biotransformation of diclofenac and effects on the metabolome of primary human hepatocytes upon repeated dose exposure

European journal of pharmaceutical sciences, 2012-04, Vol.45 (5), p.716-724

2012

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Comparison of in vitro thyroxine (T4) metabolism between Wistar rat and human hepatocyte cultures

Toxicology in vitro, 2024-04, Vol.96, p.105763-105763, Article 105763

2024

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Cross-Linking of the Extracellular Matrix by the Maillard Reaction in Aging and Diabetes: An Update on "a Puzzle Nearing Resolution"

Annals of the New York Academy of Sciences, 2005-06, Vol.1043 (1), p.533-544

2005

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Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal

Archives of biochemistry and biophysics, 2002-06, Vol.402 (1), p.110-119

2002

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Formation pathways for lysine–arginine cross-links derived from hexoses and pentoses by Maillard processes

International Congress series, 2002-11, Vol.1245, p.255-261

2002

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Formation Pathways for Lysine-Arginine Cross-links Derived from Hexoses and Pentoses by Maillard Processes

The Journal of biological chemistry, 2001-06, Vol.276 (26), p.23405-23412

2001

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Formation pathways for lysine-arginine cross-links derived from hexoses and pentoses by Maillard processes: unraveling the structure of a pentosidine precursor

The Journal of biological chemistry, 2001-06, Vol.276 (26), p.23405-23412

2001

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Glucosepane Is a Major Protein Cross-link of the Senescent Human Extracellular Matrix

The Journal of biological chemistry, 2005-04, Vol.280 (13), p.12310-12315

2005

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Glucosepane is a major protein cross-link of the senescent human extracellular matrix. Relationship with diabetes

The Journal of biological chemistry, 2005-04, Vol.280 (13), p.12310-12315

2005

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Green Tea (Camellia sinensis) Ameliorates Retinopathy and Renal Mitochondrial Defects but Deteriorates Collagen Glycoxidation and Cross-Linking in Experimental Diabetes

Annals of the New York Academy of Sciences, 2005-06, Vol.1043 (1), p.940-940

2005

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HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro

Journal of pharmacological and toxicological methods, 2011-01, Vol.63 (1), p.59-68

2011

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Heteroaryl-Substituted Naphthalenes and Structurally Modified Derivatives: Selective Inhibitors of CYP11B2 for the Treatment of Congestive Heart Failure and Myocardial Fibrosis

Journal of medicinal chemistry, 2005-10, Vol.48 (21), p.6632-6642

2005

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Identification and Quantification of Major Maillard Cross-links in Human Serum Albumin and Lens Protein

The Journal of biological chemistry, 2002-07, Vol.277 (28), p.24907-24915

2002

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Identification and quantification of major maillard cross-links in human serum albumin and lens protein. Evidence for glucosepane as the dominant compound

The Journal of biological chemistry, 2002-07, Vol.277 (28), p.24907-24915

2002

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Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids

Journal of medicinal chemistry, 2006-01, Vol.49 (2), p.748-759

2006

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Novel 5α-Reductase Inhibitors: Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids

Journal of medicinal chemistry, 2006-01, Vol.49 (2), p.748-759

2006

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Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: Improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking

Diabetes (New York, N.Y.), 2005-02, Vol.54 (2), p.517-526

2005

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Paradoxical Effects of Green Tea (Camellia Sinensis) and Antioxidant Vitamins in Diabetic Rats

Diabetes (New York, N.Y.), 2005-02, Vol.54 (2), p.517-526

2005

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Profils de Jan Patočka

1992

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Pyridinium-carbaldehyde: active Maillard reaction product from the reaction of hexoses with lysine residues

Carbohydrate research, 2004-02, Vol.339 (3), p.705-714

2004

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Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studies: Serum-free culture of primary human hepatocyte bioreactor

Journal of tissue engineering and regenerative medicine, 2015-09, Vol.9 (9), p.1017-1026

2015

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Site-Specific Quantitative Evaluation of the Protein Glycation Product N 6-(2,3-Dihydroxy-5,6-dioxohexyl)-l-lysinate by LC−(ESI)MS Peptide Mapping: Evidence for Its Key Role in AGE Formation

Bioconjugate chemistry, 2003-05, Vol.14 (3), p.619-628

2003

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Site-Specific Quantitative Evaluation of the Protein Glycation Product N6-(2,3-Dihydroxy-5,6-dioxohexyl)-l-lysinate by LC−(ESI)MS Peptide Mapping: Evidence for Its Key Role in AGE Formation

Bioconjugate chemistry, 2003-05, Vol.14 (3), p.619-628

2003

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Spiro Cross-Links: Representatives of a New Class of Glycoxidation Products

Journal of agricultural and food chemistry, 2003-07, Vol.51 (16), p.4810-4818

2003

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Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies

Biotransformation of diclofenac and effects on the metabolome of primary human hepatocytes upon repeated dose exposure

Comparison of in vitro thyroxine (T4) metabolism between Wistar rat and human hepatocyte cultures

Cross-Linking of the Extracellular Matrix by the Maillard Reaction in Aging and Diabetes: An Update on "a Puzzle Nearing Resolution"

Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal

Formation pathways for lysine–arginine cross-links derived from hexoses and pentoses by Maillard processes

Formation Pathways for Lysine-Arginine Cross-links Derived from Hexoses and Pentoses by Maillard Processes

Formation pathways for lysine-arginine cross-links derived from hexoses and pentoses by Maillard processes: unraveling the structure of a pentosidine precursor

Glucosepane Is a Major Protein Cross-link of the Senescent Human Extracellular Matrix

Glucosepane is a major protein cross-link of the senescent human extracellular matrix. Relationship with diabetes

Green Tea (Camellia sinensis) Ameliorates Retinopathy and Renal Mitochondrial Defects but Deteriorates Collagen Glycoxidation and Cross-Linking in Experimental Diabetes

HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro

Heteroaryl-Substituted Naphthalenes and Structurally Modified Derivatives: Selective Inhibitors of CYP11B2 for the Treatment of Congestive Heart Failure and Myocardial Fibrosis

Identification and Quantification of Major Maillard Cross-links in Human Serum Albumin and Lens Protein

Identification and quantification of major maillard cross-links in human serum albumin and lens protein. Evidence for glucosepane as the dominant compound

Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids

Novel 5α-Reductase Inhibitors: Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids

Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: Improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking

Paradoxical Effects of Green Tea (Camellia Sinensis) and Antioxidant Vitamins in Diabetic Rats

Profils de Jan Patočka

Pyridinium-carbaldehyde: active Maillard reaction product from the reaction of hexoses with lysine residues

Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studies: Serum-free culture of primary human hepatocyte bioreactor

Site-Specific Quantitative Evaluation of the Protein Glycation Product N 6-(2,3-Dihydroxy-5,6-dioxohexyl)-l-lysinate by LC−(ESI)MS Peptide Mapping: Evidence for Its Key Role in AGE Formation

Site-Specific Quantitative Evaluation of the Protein Glycation Product N6-(2,3-Dihydroxy-5,6-dioxohexyl)-l-lysinate by LC−(ESI)MS Peptide Mapping: Evidence for Its Key Role in AGE Formation

Spiro Cross-Links: Representatives of a New Class of Glycoxidation Products

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