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Recent Advances in CNS P2X7 Physiology and Pharmacology: Focus on Neuropsychiatric Disorders

Frontiers in pharmacology, 2018-02, Vol.9, p.30-30

Bhattacharya, Anindya

2018

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The microglial ATP-gated ion channel P2X7 as a CNS drug target

Glia, 2016-10, Vol.64 (10), p.1772-1787

2016

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Mouse primary microglia respond differently to LPS and poly(I:C) in vitro

Scientific reports, 2021-05, Vol.11 (1), p.10447-10447, Article 10447

2021

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The role of microglial P2X7: modulation of cell death and cytokine release

Journal of neuroinflammation, 2017-07, Vol.14 (1), p.135-135, Article 135

2017

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A GPU-accelerated algorithm for biclustering analysis and detection of condition-dependent coexpression network modules

Scientific reports, 2017-06, Vol.7 (1), p.4162-9, Article 4162

2017

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CTCFBSDB 2.0: a database for CTCF-binding sites and genome organization

Nucleic acids research, 2013-01, Vol.41 (Database issue), p.D188-D194

2013

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RNA sequencing analysis reveals quiescent microglia isolation methods from postnatal mouse brains and limitations of BV2 cells

Journal of neuroinflammation, 2018-05, Vol.15 (1), p.153-153, Article 153

2018

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SomamiR: a database for somatic mutations impacting microRNA function in cancer

Nucleic acids research, 2013-01, Vol.41 (Database issue), p.D977-D982

2013

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Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor

Glia, 2016-10, Vol.64 (10), p.1788-1794

2016

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Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

The Journal of neuroscience, 2016-06, Vol.36 (22), p.5920-5932

2016

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Offshore manufacturing contract design based on transfer price considering green tax: a bilevel programming approach

International journal of production research, 2018-03, Vol.56 (5), p.1825-1849

2018

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Clinical pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-54175446, a brain permeable P2X7 antagonist, in a randomised single-ascending dose study in healthy participants

Journal of psychopharmacology (Oxford), 2018-12, Vol.32 (12), p.1341-1350

2018

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SomamiR 2.0: a database of cancer somatic mutations altering microRNA-ceRNA interactions

Nucleic acids research, 2016-01, Vol.44 (D1), p.D1005-D1010

2016

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Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432

The Journal of pharmacology and experimental therapeutics, 2014-12, Vol.351 (3), p.628-641

2014

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Systematic Prediction of the Impacts of Mutations in MicroRNA Seed Sequences

Journal of integrative bioinformatics, 2017-05, Vol.14 (1), p.323-32

2017

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Analytical validation and performance characteristics of a 48-gene next-generation sequencing panel for detecting potentially actionable genomic alterations in myeloid neoplasms

PloS one, 2021-04, Vol.16 (4), p.e0243683-e0243683

2021

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Divisive Correlation Clustering Algorithm (DCCA) for grouping of genes: detecting varying patterns in expression profiles

Bioinformatics, 2008-06, Vol.24 (11), p.1359-1366

2008

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Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function

American journal of physiology. Regulatory, integrative and comparative physiology, 2010-03, Vol.298 (3), p.R534-R547

2010

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Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development

Frontiers in pharmacology, 2019-08, Vol.10, p.840-840

2019

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Epigenome-wide association study of DNA methylation and microRNA expression highlights novel pathways for human complex traits

Epigenetics, 2020-02, Vol.15 (1-2), p.183-198

2020

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Integrative analysis of somatic mutations altering microRNA targeting in cancer genomes

PloS one, 2012-10, Vol.7 (10), p.e47137

2012

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Targeting neuroinflammation with brain penetrant P2X7 antagonists as novel therapeutics for neuropsychiatric disorders

Neuropsychopharmacology (New York, N.Y.), 2020-01, Vol.45 (1), p.234-235

2020

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Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice

Frontiers in pharmacology, 2024-01, Vol.14, p.1308478-1308478

2024

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Chronic administration of P2X7 receptor antagonist JNJ-47965567 delays disease onset and progression, and improves motor performance in ALS SOD1G93A female mice

Disease models & mechanisms, 2020-10, Vol.13 (10)

2020

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Systematic analysis of microRNA targeting impacted by small insertions and deletions in human genome

PloS one, 2012-09, Vol.7 (9), p.e46176

2012

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Recent Advances in CNS P2X7 Physiology and Pharmacology: Focus on Neuropsychiatric Disorders

The microglial ATP-gated ion channel P2X7 as a CNS drug target

Mouse primary microglia respond differently to LPS and poly(I:C) in vitro

The role of microglial P2X7: modulation of cell death and cytokine release

A GPU-accelerated algorithm for biclustering analysis and detection of condition-dependent coexpression network modules

CTCFBSDB 2.0: a database for CTCF-binding sites and genome organization

RNA sequencing analysis reveals quiescent microglia isolation methods from postnatal mouse brains and limitations of BV2 cells

SomamiR: a database for somatic mutations impacting microRNA function in cancer

Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor

Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

Offshore manufacturing contract design based on transfer price considering green tax: a bilevel programming approach

Clinical pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-54175446, a brain permeable P2X7 antagonist, in a randomised single-ascending dose study in healthy participants

SomamiR 2.0: a database of cancer somatic mutations altering microRNA-ceRNA interactions

Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432

Systematic Prediction of the Impacts of Mutations in MicroRNA Seed Sequences

Analytical validation and performance characteristics of a 48-gene next-generation sequencing panel for detecting potentially actionable genomic alterations in myeloid neoplasms

Divisive Correlation Clustering Algorithm (DCCA) for grouping of genes: detecting varying patterns in expression profiles

Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function

Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development

Epigenome-wide association study of DNA methylation and microRNA expression highlights novel pathways for human complex traits

Integrative analysis of somatic mutations altering microRNA targeting in cancer genomes

Targeting neuroinflammation with brain penetrant P2X7 antagonists as novel therapeutics for neuropsychiatric disorders

Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice

Chronic administration of P2X7 receptor antagonist JNJ-47965567 delays disease onset and progression, and improves motor performance in ALS SOD1G93A female mice

Systematic analysis of microRNA targeting impacted by small insertions and deletions in human genome

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