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Look and Outlook on Enzyme-Mediated Macrolide Resistance

Frontiers in microbiology, 2018-08, Vol.9, p.1942-1942

2018

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Structural elucidation of substrate-bound aminoglycoside acetyltransferase (3)-IIIa

PloS one, 2022-08, Vol.17 (8), p.e0269684-e0269684

2022

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Structural and functional insights into esterase-mediated macrolide resistance

Nature communications, 2021-03, Vol.12 (1), p.1732-9, Article 1732

2021

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Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumors

Acta neuropathologica, 2016-06, Vol.131 (6), p.847-863

2016

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A Recurrent PDGFRB Mutation Causes Familial Infantile Myofibromatosis

American journal of human genetics, 2013-06, Vol.92 (6), p.996-1000

2013

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Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product

Nature communications, 2017-01, Vol.8 (1), p.14132-14132, Article 14132

2017

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TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw

Nature communications, 2018-11, Vol.9 (1), p.4572-8, Article 4572

2018

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Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2″)-Ia

Structure (London), 2016-06, Vol.24 (6), p.935-945

2016

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Overlapping and distinct roles of Aspergillus fumigatus UDP-glucose 4-epimerases in galactose metabolism and the synthesis of galactose-containing cell wall polysaccharides

The Journal of biological chemistry, 2014-01, Vol.289 (3), p.1243-1256

2014

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Structural and phylogenetic analyses of resistance to next-generation aminoglycosides conferred by AAC(2′) enzymes

Scientific reports, 2021-06, Vol.11 (1), p.11614-11614, Article 11614

2021

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Identifying Markers of Emerging SARS-CoV-2 Variants in Patients With Secondary Immunodeficiency

Frontiers in microbiology, 2022-07, Vol.13, p.933983-933983

2022

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The Substrate-Bound Crystal Structure of a Baeyer–Villiger Monooxygenase Exhibits a Criegee-like Conformation

Journal of the American Chemical Society, 2012-05, Vol.134 (18), p.7788-7795

2012

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Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective

Frontiers in chemistry, 2021-01, Vol.8, p.612728-612728

2021

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A potential gain-of-function variant of SLC9A6 leads to endosomal alkalinization and neuronal atrophy associated with Christianson Syndrome

Neurobiology of disease, 2019-01, Vol.121, p.187-204

2019

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Crystal Structures of Cyclohexanone Monooxygenase Reveal Complex Domain Movements and a Sliding Cofactor

Journal of the American Chemical Society, 2009-07, Vol.131 (25), p.8848-8854

2009

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Structural Analysis of the Tobramycin and Gentamicin Clinical Resistome Reveals Limitations for Next-generation Aminoglycoside Design

ACS chemical biology, 2016-05, Vol.11 (5), p.1339-1346

2016

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ZBTB7B (ThPOK) Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis

Infection and immunity, 2020-01, Vol.88 (2)

2020

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Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase

PloS one, 2017-10, Vol.12 (10), p.e0186447-e0186447

2017

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Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme

Nature structural & molecular biology, 2011-03, Vol.18 (3), p.288-294

2011

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Small-Angle X-Ray Scattering Analysis of the Bifunctional Antibiotic Resistance Enzyme Aminoglycoside (6′) Acetyltransferase-Ie/Aminoglycoside (2″) Phosphotransferase-Ia Reveals a Rigid Solution Structure

Antimicrobial Agents and Chemotherapy, 2012-04, Vol.56 (4), p.1899-1906

2012

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Structural analysis of a novel cyclohexylamine oxidase from Brevibacterium oxydans IH-35A

PloS one, 2013-03, Vol.8 (3), p.e60072-e60072

2013

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Effect of solvent and protein dynamics in ligand recognition and inhibition of aminoglycoside adenyltransferase 2″‐Ia

Protein science, 2017-09, Vol.26 (9), p.1852-1863

2017

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Design and Synthesis of Active Site Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Apoptosis and Inhibition of ERK Phosphorylation in Multiple Myeloma Cells

Journal of medicinal chemistry, 2012-04, Vol.55 (7), p.3201-3215

2012

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Structural Basis for Ubiquitin-Mediated Dimerization and Activation of the Ubiquitin Protein Ligase Cbl-b

Molecular cell, 2007-08, Vol.27 (3), p.474-485

2007

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Structural basis for plazomicin antibiotic action and resistance

Communications biology, 2021-06, Vol.4 (1), p.729-729, Article 729

2021

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Look and Outlook on Enzyme-Mediated Macrolide Resistance

Structural elucidation of substrate-bound aminoglycoside acetyltransferase (3)-IIIa

Structural and functional insights into esterase-mediated macrolide resistance

Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumors

A Recurrent PDGFRB Mutation Causes Familial Infantile Myofibromatosis

Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product

TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw

Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2″)-Ia

Overlapping and distinct roles of Aspergillus fumigatus UDP-glucose 4-epimerases in galactose metabolism and the synthesis of galactose-containing cell wall polysaccharides

Structural and phylogenetic analyses of resistance to next-generation aminoglycosides conferred by AAC(2′) enzymes

Identifying Markers of Emerging SARS-CoV-2 Variants in Patients With Secondary Immunodeficiency

The Substrate-Bound Crystal Structure of a Baeyer–Villiger Monooxygenase Exhibits a Criegee-like Conformation

Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective

A potential gain-of-function variant of SLC9A6 leads to endosomal alkalinization and neuronal atrophy associated with Christianson Syndrome

Crystal Structures of Cyclohexanone Monooxygenase Reveal Complex Domain Movements and a Sliding Cofactor

Structural Analysis of the Tobramycin and Gentamicin Clinical Resistome Reveals Limitations for Next-generation Aminoglycoside Design

ZBTB7B (ThPOK) Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis

Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase

Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme

Small-Angle X-Ray Scattering Analysis of the Bifunctional Antibiotic Resistance Enzyme Aminoglycoside (6′) Acetyltransferase-Ie/Aminoglycoside (2″) Phosphotransferase-Ia Reveals a Rigid Solution Structure

Structural analysis of a novel cyclohexylamine oxidase from Brevibacterium oxydans IH-35A

Effect of solvent and protein dynamics in ligand recognition and inhibition of aminoglycoside adenyltransferase 2″‐Ia

Design and Synthesis of Active Site Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Apoptosis and Inhibition of ERK Phosphorylation in Multiple Myeloma Cells

Structural Basis for Ubiquitin-Mediated Dimerization and Activation of the Ubiquitin Protein Ligase Cbl-b

Structural basis for plazomicin antibiotic action and resistance

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