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In Vitro Testing for Hypersensitivity‐Mediated Adverse Drug Reactions: Challenges and Future Directions

Clinical pharmacology and therapeutics, 2011-09, Vol.90 (3), p.455-460

2011

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Grapefruit juice-terfenadine single-dose interaction: Magnitude, mechanism, and relevance

Clinical pharmacology and therapeutics, 1997-04, Vol.61 (4), p.401-409

1997

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Grapefruit juice-felodipine interaction : reproducibility and characterization with the extended release drug formulation

British journal of clinical pharmacology, 1995-08, Vol.40 (2), p.135-140

1995

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Selective Inhibitors of Cytochromes P450

Toxicology and applied pharmacology, 1994-04, Vol.125 (2), p.163-175

1994

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Grapefruit juice-felodipine interaction: Effect of naringin and 6′,7′-dihydroxybergamottin in humans

Clinical pharmacology and therapeutics, 1998-09, Vol.64 (3), p.248-256

1998

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Effects of epoxyeicosatrienoic acids on isolated hearts and ventricular myocytes

American journal of physiology. Heart and circulatory physiology, 1993-04, Vol.264 (4), p.H1154-H1160

1993

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Kinetics and selectivity of mechanism-based inhibition of guinea pig hepatic and pulmonary cytochrome P450 by N-benzyl-1-aminobenzotriazole and N-alpha-methylbenzyl-1-aminobenzotriazole

Drug metabolism and disposition, 1996-09, Vol.24 (9), p.996

1996

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Erythromycin-felodipine interaction: Magnitude, mechanism, and comparison with grapefruit juice

Clinical pharmacology and therapeutics, 1996-07, Vol.60 (1), p.25-33

1996

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Selectivity and kinetics of inactivation of rabbit hepatic cytochromes P450 2B4 and 2B5 by N-aralkylated derivatives of 1-aminobenzotriazole

Drug metabolism and disposition, 1995-05, Vol.23 (5), p.577

1995

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Stereoselectivity of styrene oxidation in microsomes and in purified cytochrome P-450 enzymes from rat liver

The Journal of pharmacology and experimental therapeutics, 1989-02, Vol.248 (2), p.492

1989

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N-aralkyl derivatives of 1-aminobenzotriazole as potent isozyme-selective mechanism-based inhibitors of rabbit pulmonary cytochrome P450 in vivo

The Journal of pharmacology and experimental therapeutics, 1993-04, Vol.265 (1), p.281

1993

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N-alkylaminobenzotriazoles as isozyme-selective suicide inhibitors of rabbit pulmonary microsomal cytochrome P-450

Molecular pharmacology, 1986-07, Vol.30 (1), p.25-32

1986

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Targeted Disruption of Soluble Epoxide Hydrolase Reveals a Role in Blood Pressure Regulation

The Journal of biological chemistry, 2000-12, Vol.275 (51), p.40504-40510

2000

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N-aralkylated derivatives of 1-aminobenzotriazole are potent isozyme- and lung-selective mechanism-based inhibitors of guinea pig cytochrome P-450 in vivo

The Journal of pharmacology and experimental therapeutics, 1994-07, Vol.270 (1), p.377

1994

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Mechanism-based inactivation of cytochrome P450 1A1 by N-aralkyl-1-aminobenzotriazoles in guinea pig kidney in vivo and in vitro: minimal effects on metabolism of arachidonic acid by renal P450-dependent monooxygenases

The Journal of pharmacology and experimental therapeutics, 1993-11, Vol.267 (2), p.758

1993

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Effects of arsenite treatment on NAD(P)H:quinone acceptor oxidoreductase activity in liver, lung, kidney, and heart of the rat. Comparison to induction by the polyaromatic hydrocarbon, beta-naphthoflavone

Drug metabolism and disposition, 1993-03, Vol.21 (2), p.334

1993

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Inactivation of rabbit pulmonary cytochrome P-450 in microsomes and isolated perfused lungs by the suicide substrate 1-aminobenzotriazole

The Journal of pharmacology and experimental therapeutics, 1985-10, Vol.235 (1), p.186

1985

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Evidence for a free radical mechanism of styrene-glutathione conjugate formation catalyzed by prostaglandin H synthase and horseradish peroxidase

The Journal of biological chemistry, 1986-12, Vol.261 (34), p.15915-15922

1986

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Defective induction of phenol glucuronidation by 3-methylcholanthrene in Gunn rats is due to the absence of a specific UDP-glucuronosyltransferase isoenzyme

Molecular pharmacology, 1987-06, Vol.31 (6), p.585-591

1987

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Microsomal cytochrome P450 1A1 dependent monooxygenase activity in guinea pig heart: induction, inhibition, and increased activity by addition of exogenous NADPH-cytochrome P450 reductase

Canadian journal of physiology and pharmacology, 1993-02, Vol.71 (2), p.151

1993

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Glutathione biosynthesis from sulfur-containing amino acids in enriched populations of Clara and type II cells and macrophages freshly isolated from rabbit lung

The Journal of pharmacology and experimental therapeutics, 1987-02, Vol.240 (2), p.376

1987

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Role of lipoxygenase, cyclooxygenase and cytochrome P-450 metabolites in contractions of isolated guinea pig pulmonary venules induced by hypoxia and anoxia

The Journal of pharmacology and experimental therapeutics, 1989-09, Vol.250 (3), p.1097

1989

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Estrogen receptor- and aryl hydrocarbon receptor-mediated activities of a coal-tar creosote

Environmental toxicology and chemistry, 2000-05, Vol.19 (5), p.1262-1271

2000

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Liver transplantation induces cytochrome P450 1A1 dependent monooxygenase activity in rat lung and kidney

Canadian journal of physiology and pharmacology, 1995-01, Vol.73 (1), p.146

1995

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Bioactivation of arachidonic acid by the cytochrome P450 monooxygenases of guinea pig lung: the orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids

Molecular pharmacology, 1994-06, Vol.45 (6), p.1273-1280

1994

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In Vitro Testing for Hypersensitivity‐Mediated Adverse Drug Reactions: Challenges and Future Directions

Grapefruit juice-terfenadine single-dose interaction: Magnitude, mechanism, and relevance

Grapefruit juice-felodipine interaction : reproducibility and characterization with the extended release drug formulation

Selective Inhibitors of Cytochromes P450

Grapefruit juice-felodipine interaction: Effect of naringin and 6′,7′-dihydroxybergamottin in humans

Effects of epoxyeicosatrienoic acids on isolated hearts and ventricular myocytes

Kinetics and selectivity of mechanism-based inhibition of guinea pig hepatic and pulmonary cytochrome P450 by N-benzyl-1-aminobenzotriazole and N-alpha-methylbenzyl-1-aminobenzotriazole

Erythromycin-felodipine interaction: Magnitude, mechanism, and comparison with grapefruit juice

Selectivity and kinetics of inactivation of rabbit hepatic cytochromes P450 2B4 and 2B5 by N-aralkylated derivatives of 1-aminobenzotriazole

Stereoselectivity of styrene oxidation in microsomes and in purified cytochrome P-450 enzymes from rat liver

N-aralkyl derivatives of 1-aminobenzotriazole as potent isozyme-selective mechanism-based inhibitors of rabbit pulmonary cytochrome P450 in vivo

N-alkylaminobenzotriazoles as isozyme-selective suicide inhibitors of rabbit pulmonary microsomal cytochrome P-450

Targeted Disruption of Soluble Epoxide Hydrolase Reveals a Role in Blood Pressure Regulation

N-aralkylated derivatives of 1-aminobenzotriazole are potent isozyme- and lung-selective mechanism-based inhibitors of guinea pig cytochrome P-450 in vivo

Mechanism-based inactivation of cytochrome P450 1A1 by N-aralkyl-1-aminobenzotriazoles in guinea pig kidney in vivo and in vitro: minimal effects on metabolism of arachidonic acid by renal P450-dependent monooxygenases

Effects of arsenite treatment on NAD(P)H:quinone acceptor oxidoreductase activity in liver, lung, kidney, and heart of the rat. Comparison to induction by the polyaromatic hydrocarbon, beta-naphthoflavone

Inactivation of rabbit pulmonary cytochrome P-450 in microsomes and isolated perfused lungs by the suicide substrate 1-aminobenzotriazole

Evidence for a free radical mechanism of styrene-glutathione conjugate formation catalyzed by prostaglandin H synthase and horseradish peroxidase

Defective induction of phenol glucuronidation by 3-methylcholanthrene in Gunn rats is due to the absence of a specific UDP-glucuronosyltransferase isoenzyme

Microsomal cytochrome P450 1A1 dependent monooxygenase activity in guinea pig heart: induction, inhibition, and increased activity by addition of exogenous NADPH-cytochrome P450 reductase

Glutathione biosynthesis from sulfur-containing amino acids in enriched populations of Clara and type II cells and macrophages freshly isolated from rabbit lung

Role of lipoxygenase, cyclooxygenase and cytochrome P-450 metabolites in contractions of isolated guinea pig pulmonary venules induced by hypoxia and anoxia

Estrogen receptor- and aryl hydrocarbon receptor-mediated activities of a coal-tar creosote

Liver transplantation induces cytochrome P450 1A1 dependent monooxygenase activity in rat lung and kidney

Bioactivation of arachidonic acid by the cytochrome P450 monooxygenases of guinea pig lung: the orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids

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