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Unmasking the Mechanism behind Miltefosine: Revealing the Disruption of Intracellular Ca2+ Homeostasis as a Rational Therapeutic Target in Leishmaniasis and Chagas Disease

Biomolecules (Basel, Switzerland), 2024-03, Vol.14 (4), p.406

2024

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The Rationale for Use of Amiodarone and its Derivatives for the Treatment of Chagas’ Disease and Leishmaniasis

Current pharmaceutical design, 2021, Vol.27 (15), p.1825-1833

2021

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Disruption of Intracellular Calcium Homeostasis as a Therapeutic Target Against Trypanosoma cruzi

Frontiers in cellular and infection microbiology, 2020-02, Vol.10, p.46-46

2020

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Effects of amiodarone, amioder, and dronedarone on Trichomonas vaginalis

Parasitology research (1987), 2022-06, Vol.121 (6), p.1761-1773

2022

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SQ109 inhibits proliferation of Leishmania donovani by disruption of intracellular Ca2+ homeostasis, collapsing the mitochondrial electrochemical potential (ΔΨm) and affecting acidocalcisomes

Parasitology research (1987), 2020-02, Vol.119 (2), p.649-657

2020

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Ca2+/Calmodulin and Apo-Calmodulin Both Bind to and Enhance the Tyrosine Kinase Activity of c-Src

PloS one, 2015-06, Vol.10 (6), p.e0128783-e0128783

2015

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Editorial: Chagas disease novel drug targets and treatments

Frontiers in cellular and infection microbiology, 2023-05, Vol.13, p.1199715-1199715

2023

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Neglected Tropical Protozoan Diseases: Drug Repositioning as a Rational Option

Current topics in medicinal chemistry, 2016-08, Vol.16 (19), p.2201-2222

2016

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Antiproliferative effect of a benzofuran derivate based on the structure of amiodarone on Leishmania donovani affecting mitochondria, acidocalcisomes and intracellular Ca2+ homeostasis

Parasitology international, 2019-06, Vol.70, p.112-117

2019

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Characterization of phospho-(tyrosine)-mimetic calmodulin mutants

PloS one, 2015-04, Vol.10 (4), p.e0120798-e0120798

2015

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Editorial: Advances in the Molecular Biology of Trypanosomatid Pathogens: New Strategies Against Ancient Enemies

Frontiers in cellular and infection microbiology, 2021-10, Vol.11, p.777008-777008

2021

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Synthesis, Antimalarial, Antileishmanial, and Cytotoxicity Activities and Preliminary In Silico ADMET Studies of 2-(7-Chloroquinolin-4-ylamino)ethyl Benzoate Derivatives

Pharmaceuticals (Basel, Switzerland), 2023-12, Vol.16 (12), p.1709

2023

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In Vitro Anti-Trypanosoma cruzi Activity of Dronedarone, a Novel Amiodarone Derivative with an Improved Safety Profile

Antimicrobial Agents and Chemotherapy, 2012-07, Vol.56 (7), p.3720-3725

2012

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Determination of Intracellular Ca2+ Concentration in the Human Pathogens Trypanosomatids Leishmania mexicana and Trypanosoma cruzi by the Use of the Fluorescent Ca2+ Indicator Fura-2

Bio-protocol, 2020-09, Vol.10 (18), p.e3766-e3766

2020

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Amiodarone Destabilizes Intracellular Ca2+ Homeostasis and Biosynthesis of Sterols in Leishmania mexicana

Antimicrobial Agents and Chemotherapy, 2009-04, Vol.53 (4), p.1403-1410

2009

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Amiodarone and Miltefosine Act Synergistically against Leishmania mexicana and Can Induce Parasitological Cure in a Murine Model of Cutaneous Leishmaniasis

Antimicrobial Agents and Chemotherapy, 2009-12, Vol.53 (12), p.5108-5113

2009

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Primary cutaneous carcinosarcoma: insights into its clonal origin and mutational pattern expression analysis through next-generation sequencing

Human pathology, 2013-12, Vol.44 (12), p.2853-2860

2013

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Unmasking the Mechanism behind Miltefosine: Revealing the Disruption of Intracellular Ca[sup.2+] Homeostasis as a Rational Therapeutic Target in Leishmaniasis and Chagas Disease

Biomolecules (Basel, Switzerland), 2024-04, Vol.14 (4)

2024

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Targeting calcium homeostasis as the therapy of Chagas' disease and leishmaniasis - a review

Tropical biomedicine, 2011-12, Vol.28 (3), p.471-481

2011

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Unmasking the Mechanism behind Miltefosine: Revealing the Disruption of Intracellular Ca 2+ Homeostasis as a Rational Therapeutic Target in Leishmaniasis and Chagas Disease

Biomolecules (Basel, Switzerland), 2024-03, Vol.14 (4)

2024

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The marine sponge toxin agelasine B increases the intracellular Ca2+ concentration and induces apoptosis in human breast cancer cells (MCF-7)

Cancer chemotherapy and pharmacology, 2012-01, Vol.69 (1), p.71-83

2012

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Mechanism of Action of Miltefosine on Leishmania donovani Involves the Impairment of Acidocalcisome Function and the Activation of the Sphingosine-Dependent Plasma Membrane Ca2+ Channel

Antimicrobial agents and chemotherapy, 2018-01, Vol.62 (1)

2018

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Inhibition of Leishmania mexicana Growth by the Tuberculosis Drug SQ109

Antimicrobial agents and chemotherapy, 2016-10, Vol.60 (10), p.6386-6389

2016

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Effects of SQ109 on Trichomonas vaginalis

Experimental parasitology, 2023-07, Vol.250, p.108549-108549, Article 108549

2023

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Investigation of a combination of amiodarone and itraconazole for treatment of American trypanosomiasis (Chagas disease) in dogs

Journal of the American Veterinary Medical Association, 2019-08, Vol.255 (3), p.317-329

2019

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Unmasking the Mechanism behind Miltefosine: Revealing the Disruption of Intracellular Ca2+ Homeostasis as a Rational Therapeutic Target in Leishmaniasis and Chagas Disease

The Rationale for Use of Amiodarone and its Derivatives for the Treatment of Chagas’ Disease and Leishmaniasis

Disruption of Intracellular Calcium Homeostasis as a Therapeutic Target Against Trypanosoma cruzi

Effects of amiodarone, amioder, and dronedarone on Trichomonas vaginalis

SQ109 inhibits proliferation of Leishmania donovani by disruption of intracellular Ca2+ homeostasis, collapsing the mitochondrial electrochemical potential (ΔΨm) and affecting acidocalcisomes

Ca2+/Calmodulin and Apo-Calmodulin Both Bind to and Enhance the Tyrosine Kinase Activity of c-Src

Editorial: Chagas disease novel drug targets and treatments

Neglected Tropical Protozoan Diseases: Drug Repositioning as a Rational Option

Antiproliferative effect of a benzofuran derivate based on the structure of amiodarone on Leishmania donovani affecting mitochondria, acidocalcisomes and intracellular Ca2+ homeostasis

Characterization of phospho-(tyrosine)-mimetic calmodulin mutants

Editorial: Advances in the Molecular Biology of Trypanosomatid Pathogens: New Strategies Against Ancient Enemies

Synthesis, Antimalarial, Antileishmanial, and Cytotoxicity Activities and Preliminary In Silico ADMET Studies of 2-(7-Chloroquinolin-4-ylamino)ethyl Benzoate Derivatives

In Vitro Anti-Trypanosoma cruzi Activity of Dronedarone, a Novel Amiodarone Derivative with an Improved Safety Profile

Determination of Intracellular Ca2+ Concentration in the Human Pathogens Trypanosomatids Leishmania mexicana and Trypanosoma cruzi by the Use of the Fluorescent Ca2+ Indicator Fura-2

Amiodarone Destabilizes Intracellular Ca2+ Homeostasis and Biosynthesis of Sterols in Leishmania mexicana

Amiodarone and Miltefosine Act Synergistically against Leishmania mexicana and Can Induce Parasitological Cure in a Murine Model of Cutaneous Leishmaniasis

Primary cutaneous carcinosarcoma: insights into its clonal origin and mutational pattern expression analysis through next-generation sequencing

Unmasking the Mechanism behind Miltefosine: Revealing the Disruption of Intracellular Ca[sup.2+] Homeostasis as a Rational Therapeutic Target in Leishmaniasis and Chagas Disease

Targeting calcium homeostasis as the therapy of Chagas' disease and leishmaniasis - a review

Unmasking the Mechanism behind Miltefosine: Revealing the Disruption of Intracellular Ca 2+ Homeostasis as a Rational Therapeutic Target in Leishmaniasis and Chagas Disease

The marine sponge toxin agelasine B increases the intracellular Ca2+ concentration and induces apoptosis in human breast cancer cells (MCF-7)

Mechanism of Action of Miltefosine on Leishmania donovani Involves the Impairment of Acidocalcisome Function and the Activation of the Sphingosine-Dependent Plasma Membrane Ca2+ Channel

Inhibition of Leishmania mexicana Growth by the Tuberculosis Drug SQ109

Effects of SQ109 on Trichomonas vaginalis

Investigation of a combination of amiodarone and itraconazole for treatment of American trypanosomiasis (Chagas disease) in dogs

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