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The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D

Journal of chemical neuroanatomy, 2010-09, Vol.40 (1), p.36-42

2010

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Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo

British journal of pharmacology, 2006-11, Vol.149 (6), p.666-675

2006

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Bronchodilator and anti‐inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes

British journal of pharmacology, 1999-08, Vol.127 (7), p.1641-1651

1999

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Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist

Naunyn-Schmiedeberg's archives of pharmacology, 1997-09, Vol.356 (3), p.328-334

1997

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Selective induction of cyclo‐oxygenase‐2 activity in the permanent human endothelial cell line HUV‐EC‐C: biochemical and pharmacological characterization

British journal of pharmacology, 1997-05, Vol.121 (2), p.171-180

1997

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Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus

British journal of pharmacology, 1993-02, Vol.108 (2), p.562-568

1993

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Synthesis and biological evaluation of a conformationally free seco-analogue of the immunosuppressant FR901483

Bioorganic & medicinal chemistry, 1999-12, Vol.7 (12), p.2891-2897

1999

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Synthesis and Biological Evaluation of 3,4-Diaryloxazolones: A New Class of Orally Active Cyclooxygenase-2 Inhibitors

Journal of medicinal chemistry, 2000-01, Vol.43 (2), p.214-223

2000

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Synthesis and Biological Evaluation of 2-Phenylpyran-4-ones: A New Class of Orally Active Cyclooxygenase-2 Inhibitors

Journal of medicinal chemistry, 2004-07, Vol.47 (15), p.3874-3886

2004

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Synthesis and Structure−Activity Relationships of Novel Histamine H 1 Antagonists: Indolylpiperidinyl Benzoic Acid Derivatives

Journal of medicinal chemistry, 2004-12, Vol.47 (25), p.6326-6337

2004

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Benzyl Derivatives of 2,1,3-Benzo- and Benzothieno[3,2-a]thiadiazine 2,2-Dioxides: First Phosphodiesterase 7 Inhibitors

Journal of medicinal chemistry, 2000-02, Vol.43 (4), p.683-689

2000

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Second messenger systems as targets for new therapeutic agents: focus on selective phosphodiesterase inhibitors

Farmaco (Società chimica italiana : 1989), 1995-12, Vol.50 (12), p.819

1995

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Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine

European journal of pharmacology, 2000-12, Vol.410 (1), p.33-41

2000

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Synthesis and structure–activity relationships of piperidinylpyrrolopyridine derivatives as potent and selective H 1 antagonists

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (4), p.1165-1167

2005

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Studies on the cardiac actions of flosequinan in vitro

British journal of pharmacology, 1992-04, Vol.105 (4), p.985-991

1992

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Synthesis and biological evaluation of 2,5-dihydropyrazolo[4,3- c]quinolin-3-ones, a novel series of PDE 4 inhibitors with low emetic potential and antiasthmatic properties

Bioorganic & medicinal chemistry letters, 2000-12, Vol.10 (23), p.2661-2664

2000

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Novel Heterocyclic-Fused Pyridazinones as Potent and Selective Phosphodiesterase IV Inhibitors

Journal of medicinal chemistry, 1997-05, Vol.40 (10), p.1417-1421

1997

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Discovery and Characterization of 4'-(2-Furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a Potent, Selective, and Efficacious A sub(2B) Adenosine Receptor Antagonist

Journal of medicinal chemistry, 2007-05, Vol.50 (11), p.2732-2736

2007

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Phosphodiesterase 7A1 is expressed in human CD4+ naïve T cells at higher levels than in CD4+ memory cells and is not required during their CD3/CD28-dependent activation

Cellular Immunology, 2006-07, Vol.242 (1), p.31-38

2006

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Phosphodiesterase inhibitory properties of losartan. design and synthesis of new lead compounds

Bioorganic & medicinal chemistry letters, 1998-03, Vol.8 (5), p.505-510

1998

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Design, Synthesis, and Biological Activities of New Thieno[3,2-d]pyrimidines as Selective Type 4 Phosphodiesterase Inhibitors

Journal of medicinal chemistry, 1998-10, Vol.41 (21), p.4021-4035

1998

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Anticholinergic effects of desloratadine, the major metabolite of loratadine, in rabbit and guinea-pig iris smooth muscle

European journal of pharmacology, 1999-06, Vol.374 (2), p.249-254

1999

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Identification and characterization of serotonin 5-HT4 receptor binding sites in human brain : comparison with other mammalian species

Brain research. Molecular brain research., 1994, Vol.21 (1-2), p.176-180

1994

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Inhibition of eotaxin‐mediated human eosinophil activation and migration by the selective cyclic nucleotide phosphodiesterase type 4 inhibitor rolipram

British journal of pharmacology, 1997-07, Vol.121 (6), p.1150-1154

1997

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Characterization of 5‐HT receptors on human pulmonary artery and vein: functional and binding studies

British journal of pharmacology, 1997-12, Vol.122 (7), p.1455-1463

1997

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The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D

Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo

Bronchodilator and anti‐inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes

Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist

Selective induction of cyclo‐oxygenase‐2 activity in the permanent human endothelial cell line HUV‐EC‐C: biochemical and pharmacological characterization

Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus

Synthesis and biological evaluation of a conformationally free seco-analogue of the immunosuppressant FR901483

Synthesis and Biological Evaluation of 3,4-Diaryloxazolones: A New Class of Orally Active Cyclooxygenase-2 Inhibitors

Synthesis and Biological Evaluation of 2-Phenylpyran-4-ones: A New Class of Orally Active Cyclooxygenase-2 Inhibitors

Synthesis and Structure−Activity Relationships of Novel Histamine H 1 Antagonists: Indolylpiperidinyl Benzoic Acid Derivatives

Benzyl Derivatives of 2,1,3-Benzo- and Benzothieno[3,2-a]thiadiazine 2,2-Dioxides: First Phosphodiesterase 7 Inhibitors

Second messenger systems as targets for new therapeutic agents: focus on selective phosphodiesterase inhibitors

Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine

Synthesis and structure–activity relationships of piperidinylpyrrolopyridine derivatives as potent and selective H 1 antagonists

Studies on the cardiac actions of flosequinan in vitro

Synthesis and biological evaluation of 2,5-dihydropyrazolo[4,3- c]quinolin-3-ones, a novel series of PDE 4 inhibitors with low emetic potential and antiasthmatic properties

Novel Heterocyclic-Fused Pyridazinones as Potent and Selective Phosphodiesterase IV Inhibitors

Discovery and Characterization of 4'-(2-Furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a Potent, Selective, and Efficacious A sub(2B) Adenosine Receptor Antagonist

Phosphodiesterase 7A1 is expressed in human CD4+ naïve T cells at higher levels than in CD4+ memory cells and is not required during their CD3/CD28-dependent activation

Phosphodiesterase inhibitory properties of losartan. design and synthesis of new lead compounds

Design, Synthesis, and Biological Activities of New Thieno[3,2-d]pyrimidines as Selective Type 4 Phosphodiesterase Inhibitors

Anticholinergic effects of desloratadine, the major metabolite of loratadine, in rabbit and guinea-pig iris smooth muscle

Identification and characterization of serotonin 5-HT4 receptor binding sites in human brain : comparison with other mammalian species

Inhibition of eotaxin‐mediated human eosinophil activation and migration by the selective cyclic nucleotide phosphodiesterase type 4 inhibitor rolipram

Characterization of 5‐HT receptors on human pulmonary artery and vein: functional and binding studies

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