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Synthesis and Activity of New Aryl- and Heteroaryl-Substituted Pyrazole Inhibitors of the Transforming Growth Factor-β Type I Receptor Kinase Domain

Journal of medicinal chemistry, 2003-09, Vol.46 (19), p.3953-3956

2003

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Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain

Bioorganic & medicinal chemistry letters, 2004-07, Vol.14 (13), p.3581-3584

2004

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Carbocyclic[g]indole Inhibitors of Human Nonpancreatic s-PLA2

Journal of medicinal chemistry, 2005-02, Vol.48 (3), p.893-896

2005

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N 2-Aroylanthranilamide Inhibitors of Human Factor Xa

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.873-882

2000

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Inhibition of thrombin activatable fibrinolysis inhibitor by cysteine derivatives

Thrombosis research, 2005, Vol.116 (3), p.265-271

2005

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Application of a conformationally restricted Phe-Leu dipeptide mimetic to the design of a combined inhibitor of angiotensin I-converting enzyme and neutral endopeptidase 24.11

Journal of medicinal chemistry, 1993-08, Vol.36 (16), p.2420-2423

1993

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1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.859-872

2000

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N(2)-Aroylanthranilamide inhibitors of human factor Xa

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.873-882

2000

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The synthesis of fluorinated aminophosphonic acid inhibitors of alanine racemase

Tetrahedron letters, 1985, Vol.26 (3), p.285-288

1985

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The conversion of a diazolactam to an α-methylenelactam: An entrance to new conformationally restricted inhibitors of angiotensin-converting enzyme

Tetrahedron letters, 1990, Vol.31 (6), p.815-818

1990

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Carbocyclic[ g ]indole Inhibitors of Human Nonpancreatic s-PLA 2

Journal of medicinal chemistry, 2005-02, Vol.48 (3), p.893-896

2005

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Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4 H-pyrrolo[1,2- b]pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain

Bioorganic & medicinal chemistry letters, 2004, Vol.14 (13), p.3581-3584

2004

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Synthesis of protected 4-demethoxy-8-nordaunomycinone

Journal of organic chemistry, 1984-06, Vol.49 (12), p.2252-2258

1984

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Synthesis of constrained thiorphan analogs as inhibitors of neutral endopeptidase

Bioorganic & medicinal chemistry letters, 1996-09, Vol.6 (17), p.2053-2058

1996

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N2-Aroylanthranilamide Inhibitors of Human Factor Xa

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.873-882

2000

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An efficient synthesis of ethyl (R)-2-hydroxy-4-phenylbutyrate: A useful intermediate in the synthesis of converting enzymeinhibitors

Tetrahedron letters, 1988, Vol.29 (4), p.423-426

1988

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A dehydroalanine route to an activated phenolic sparsomycin analog

Tetrahedron letters, 1984, Vol.25 (25), p.2655-2658

1984

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Interaction of Angiotensin I-Converting Enzyme with Two Potent Tricyclic Inhibitors

Journal of enzyme inhibition, 1989, Vol.2 (4), p.269-277

1989

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Kinetic Characterization of Novel Pyrazole TGF-β Receptor I Kinase Inhibitors and Their Blockade of the Epithelial−Mesenchymal Transition

Biochemistry (Easton), 2005-02, Vol.44 (7), p.2293-2304

2005

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Synthesis of protected 4-desmethoxy-8-nordaunomycinone

Journal of organic chemistry, 1984, Vol.49 (12), p.2252-2258

1984

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Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor

Synthesis and Activity of New Aryl- and Heteroaryl-Substituted Pyrazole Inhibitors of the Transforming Growth Factor-β Type I Receptor Kinase Domain

Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain

Carbocyclic[g]indole Inhibitors of Human Nonpancreatic s-PLA2

N 2-Aroylanthranilamide Inhibitors of Human Factor Xa

Inhibition of thrombin activatable fibrinolysis inhibitor by cysteine derivatives

Application of a conformationally restricted Phe-Leu dipeptide mimetic to the design of a combined inhibitor of angiotensin I-converting enzyme and neutral endopeptidase 24.11

1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa

N(2)-Aroylanthranilamide inhibitors of human factor Xa

The synthesis of fluorinated aminophosphonic acid inhibitors of alanine racemase

The conversion of a diazolactam to an α-methylenelactam: An entrance to new conformationally restricted inhibitors of angiotensin-converting enzyme

Carbocyclic[ g ]indole Inhibitors of Human Nonpancreatic s-PLA 2

Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4 H-pyrrolo[1,2- b]pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain

Synthesis of protected 4-demethoxy-8-nordaunomycinone

Synthesis of constrained thiorphan analogs as inhibitors of neutral endopeptidase

N2-Aroylanthranilamide Inhibitors of Human Factor Xa

An efficient synthesis of ethyl (R)-2-hydroxy-4-phenylbutyrate: A useful intermediate in the synthesis of converting enzymeinhibitors

A dehydroalanine route to an activated phenolic sparsomycin analog

Interaction of Angiotensin I-Converting Enzyme with Two Potent Tricyclic Inhibitors

Kinetic Characterization of Novel Pyrazole TGF-β Receptor I Kinase Inhibitors and Their Blockade of the Epithelial−Mesenchymal Transition

Synthesis of protected 4-desmethoxy-8-nordaunomycinone

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