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Synthesis of Rhazinicine by a Metal-Catalyzed CH Bond Functionalization Strategy

Angewandte Chemie International Edition, 2008-04, Vol.47 (16), p.3004-3007

2008

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Pd-Catalyzed C–H Bond Functionalization on the Indole and Pyrrole Nucleus

C-H Activation, 2010-01, Vol.292, p.85-121

2010

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Oxidative Pd(II)-Catalyzed C−H Bond Amination to Carbazole at Ambient Temperature

Journal of the American Chemical Society, 2008-12, Vol.130 (48), p.16184-16186

2008

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Chemical Synthesis of Aspidosperma Alkaloids Inspired by the Reverse of the Biosynthesis of the Rhazinilam Family of Natural Products

Angewandte Chemie International Edition, 2012-09, Vol.51 (37), p.9288-9291

International ed. in English, 2012

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Mild Aerobic Oxidative Palladium (II) Catalyzed C−H Bond Functionalization: Regioselective and Switchable C−H Alkenylation and Annulation of Pyrroles

Journal of the American Chemical Society, 2006-03, Vol.128 (8), p.2528-2529

2006

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Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors

Nature communications, 2016-10, Vol.7 (1), p.13042-14, Article 13042

2016

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Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase

Journal of medicinal chemistry, 2017-12, Vol.60 (23), p.9860-9873

2017

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The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging

Journal of medicinal chemistry, 2017-10, Vol.60 (20), p.8538-8551

2017

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Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1

Cells (Basel, Switzerland), 2019-11, Vol.8 (11), p.1425

2019

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Temporal changes in avian abundance in aspen-dominated boreal mixedwood forests of central Saskatchewan, Canada

Avian conservation and ecology, 2018-06, Vol.13 (1), p.3, Article art3

2018

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Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4568-4579

2013

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Biased representation of disturbance rates in the roadside sampling frame in boreal forests: implications for monitoring design

Avian conservation and ecology, 2015-12, Vol.10 (2), p.5, Article art5

2015

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Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M4 Muscarinic Acetylcholine Receptor

Journal of medicinal chemistry, 2024-07, Vol.67 (13), p.10831-10847

2024

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Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M 4 Muscarinic Acetylcholine Receptor

Journal of medicinal chemistry, 2024-07, Vol.67 (13), p.10831-10847

2024

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Chiral Sulfinamide/Achiral Sulfonic Acid Cocatalyzed Enantioselective Protonation of Enol Silanes

Organic letters, 2011-08, Vol.13 (16), p.4260-4263

2011

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Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality

Journal of medicinal chemistry, 2017-01, Vol.60 (1), p.386-402

2017

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Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain

Journal of medicinal chemistry, 2018-04, Vol.61 (8), p.3296-3308

2018

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Synthesis and Structure‐Activity Relationships of N‐(4‐Benzamidino)‐Oxazolidinones: Potent and Selective Inhibitors of Kallikrein‐Related Peptidase 6

ChemMedChem, 2020-01, Vol.15 (1), p.79-95

2020

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Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design

Journal of medicinal chemistry, 2015-03, Vol.58 (6), p.2678-2702

2015

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Health of Domestic Mallards (Anas platyrhynchos domestica) Following Exposure to Oil Sands Process-Affected Water

Environmental science & technology, 2014-08, Vol.48 (15), p.8847-8854

2014

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Chemical Synthesis of Aspidosperma Alkaloids Inspired by the Reverse of the Biosynthesis of the Rhazinilam Family of Natural Products

Angewandte Chemie, 2012-09, Vol.124 (37), p.9422-9425

2012

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The synthesis and in vivo evaluation of [18 F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH)

Nuclear medicine and biology, 2012-10, Vol.39 (7), p.1058-1067

2012

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Bend-ribbon forming gamma-peptides

Chemical communications (Cambridge, England), 2007-01 (27), p.2814-2816

2007

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Evidence of low toxicity of oil sands process-affected water to birds invites re-evaluation of avian protection strategies

Conservation physiology, 2015, Vol.3 (1), p.cov038

2015

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Synthesis of Rhazinicine by a Metal-Catalyzed CH Bond Functionalization Strategy

Pd-Catalyzed C–H Bond Functionalization on the Indole and Pyrrole Nucleus

Oxidative Pd(II)-Catalyzed C−H Bond Amination to Carbazole at Ambient Temperature

Chemical Synthesis of Aspidosperma Alkaloids Inspired by the Reverse of the Biosynthesis of the Rhazinilam Family of Natural Products

Mild Aerobic Oxidative Palladium (II) Catalyzed C−H Bond Functionalization: Regioselective and Switchable C−H Alkenylation and Annulation of Pyrroles

Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors

Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase

The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging

Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1

Temporal changes in avian abundance in aspen-dominated boreal mixedwood forests of central Saskatchewan, Canada

Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand

Biased representation of disturbance rates in the roadside sampling frame in boreal forests: implications for monitoring design

Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M4 Muscarinic Acetylcholine Receptor

Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M 4 Muscarinic Acetylcholine Receptor

Chiral Sulfinamide/Achiral Sulfonic Acid Cocatalyzed Enantioselective Protonation of Enol Silanes

Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors

Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality

Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain

Synthesis and Structure‐Activity Relationships of N‐(4‐Benzamidino)‐Oxazolidinones: Potent and Selective Inhibitors of Kallikrein‐Related Peptidase 6

Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design

Health of Domestic Mallards (Anas platyrhynchos domestica) Following Exposure to Oil Sands Process-Affected Water

Chemical Synthesis of Aspidosperma Alkaloids Inspired by the Reverse of the Biosynthesis of the Rhazinilam Family of Natural Products

The synthesis and in vivo evaluation of [18 F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH)

Bend-ribbon forming gamma-peptides

Evidence of low toxicity of oil sands process-affected water to birds invites re-evaluation of avian protection strategies

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