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Expression and analysis of the human cytomegalovirus UL80-encoded protease: identification of autoproteolytic sites

Journal of Virology, 1993-01, Vol.67 (1), p.497-506

1993

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Proteolytic activity of human cytomegalovirus UL80 protease cleavage site mutants

Journal of Virology, 1994-06, Vol.68 (6), p.3742-3752

1994

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Isolation of Mutants of Human Immunodeficiency Virus Protease Based on the Toxicity of the Enzyme in Escherichia coli

Proceedings of the National Academy of Sciences - PNAS, 1990-07, Vol.87 (14), p.5573-5577

1990

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β-Galactosidase Containing a Human Immunodeficiency Virus Protease Cleavage Site is Cleaved and Inactivated by Human Immunodeficiency Virus Protease

Proceedings of the National Academy of Sciences - PNAS, 1990-12, Vol.87 (24), p.10023-10027

1990

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Characterization of the Monomer−Dimer Equilibrium of Human Cytomegalovirus Protease by Kinetic Methods

Biochemistry (Easton), 2004-01, Vol.43 (2), p.316-322

2004

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Purification, properties, and mutagenesis of poliovirus 3C protease

Virology (New York, N.Y.), 1991-11, Vol.185 (1), p.140-150

1991

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Flavins Inhibit Human Cytomegalovirus UL80 Protease via Disulfide Bond Formation

Biochemistry (Easton), 1996-05, Vol.35 (18), p.5847-5855

1996

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Inhibition of Human Cytomegalovirus UL80 Protease by Specific Intramolecular Disulfide Bond Formation

Biochemistry (Easton), 1996-05, Vol.35 (18), p.5838-5846

1996

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K-ras oncogene expression in Xenopus laevis

Oncogene, 1990-05, Vol.5 (5), p.763-767

1990

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Rapid methods for screening low molecular mass compounds non-covalently bound to proteins using size exclusion and mass spectrometry applied to inhibitors of human cytomegalovirus protease

Journal of mass spectrometry., 1998-03, Vol.33 (3), p.264-273

1998

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Design and Syntheses of 1,6-Naphthalene Derivatives as Selective HCMV Protease Inhibitors

Journal of medicinal chemistry, 2004-04, Vol.47 (8), p.1893-1899

2004

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Development of a scintillation proximity assay for human cytomegalovirus protease using 33phosphorous

Analytical biochemistry, 1996-05, Vol.237 (1), p.129-134

1996

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Expression and analysis of the human cytomegalovirus UL80-encoded protease: Identification of autoproteolytic sites

Journal of virology, 1993-01, Vol.67 (2), p.497-506

1993

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The Effect of 1,3-Diaryl-[1H]-pyrazole-4-acetamides on Glucose Utilization in ob/ob Mice

Journal of medicinal chemistry, 2001-08, Vol.44 (16), p.2601-2611

2001

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Discovery of (2R)‑N‑[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]‑1H‑indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Journal of medicinal chemistry, 2020-05, Vol.63 (9), p.4517-4527

2020

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Abstract 979: Discovery of the JAK1 selective kinase inhibitor AZD4205

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.979-979

2017

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The impact of fatty acid oxidation on energy utilization: targets and therapy

Current pharmaceutical design, 2002-06, Vol.8 (14), p.1199-1227

2002

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Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors

Journal of medicinal chemistry, 2018-06, Vol.61 (12), p.5235-5244

2018

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Discovery of (2 R )- N -[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1 H -indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Journal of medicinal chemistry, 2020-05, Vol.63 (9), p.4517-4527

2020

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Anilides of (R)-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase

Journal of medicinal chemistry, 2000-06, Vol.43 (11), p.2248-2257

2000

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Reduction in Glucose Levels in STZ Diabetic Rats by 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid: A Prodrug Approach for Targeting the Liver

Journal of medicinal chemistry, 2001-02, Vol.44 (4), p.512-523

2001

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Hypoglycemic Prodrugs of 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid

Journal of medicinal chemistry, 1999-01, Vol.42 (1), p.153-163

1999

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Reduction in Glucose Levels in STZ Diabetic Rats by 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid: A Prodrug Approach for Targeting the Liver

Journal of medicinal chemistry, 2002-02, Vol.45 (5), p.1150-1150

2002

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Pyrimido[1,2-b]-1,2,4,5-tetrazin-6-ones as HCMV protease inhibitors: A new class of heterocycles with flavin-like redox properties

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (20), p.3483-3486

2003

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( R )-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides Are Orally Active Inhibitors of Pyruvate Dehydrogenase Kinase

Journal of medicinal chemistry, 1999-07, Vol.42 (15), p.2741-2746

1999

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Expression and analysis of the human cytomegalovirus UL80-encoded protease: identification of autoproteolytic sites

Proteolytic activity of human cytomegalovirus UL80 protease cleavage site mutants

Isolation of Mutants of Human Immunodeficiency Virus Protease Based on the Toxicity of the Enzyme in Escherichia coli

β-Galactosidase Containing a Human Immunodeficiency Virus Protease Cleavage Site is Cleaved and Inactivated by Human Immunodeficiency Virus Protease

Characterization of the Monomer−Dimer Equilibrium of Human Cytomegalovirus Protease by Kinetic Methods

Purification, properties, and mutagenesis of poliovirus 3C protease

Flavins Inhibit Human Cytomegalovirus UL80 Protease via Disulfide Bond Formation

Inhibition of Human Cytomegalovirus UL80 Protease by Specific Intramolecular Disulfide Bond Formation

K-ras oncogene expression in Xenopus laevis

Rapid methods for screening low molecular mass compounds non-covalently bound to proteins using size exclusion and mass spectrometry applied to inhibitors of human cytomegalovirus protease

Design and Syntheses of 1,6-Naphthalene Derivatives as Selective HCMV Protease Inhibitors

Development of a scintillation proximity assay for human cytomegalovirus protease using 33phosphorous

Expression and analysis of the human cytomegalovirus UL80-encoded protease: Identification of autoproteolytic sites

The Effect of 1,3-Diaryl-[1H]-pyrazole-4-acetamides on Glucose Utilization in ob/ob Mice

Discovery of (2R)‑N‑[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]‑1H‑indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Abstract 979: Discovery of the JAK1 selective kinase inhibitor AZD4205

The impact of fatty acid oxidation on energy utilization: targets and therapy

Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors

Discovery of (2 R )- N -[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1 H -indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Anilides of (R)-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase

Reduction in Glucose Levels in STZ Diabetic Rats by 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid: A Prodrug Approach for Targeting the Liver

Hypoglycemic Prodrugs of 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid

Reduction in Glucose Levels in STZ Diabetic Rats by 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid: A Prodrug Approach for Targeting the Liver

Pyrimido[1,2-b]-1,2,4,5-tetrazin-6-ones as HCMV protease inhibitors: A new class of heterocycles with flavin-like redox properties

( R )-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides Are Orally Active Inhibitors of Pyruvate Dehydrogenase Kinase

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