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High-resolution structure and strain comparison of infectious mammalian prions

Molecular cell, 2021-11, Vol.81 (21), p.4540-4551.e6

2021

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Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions

Annual review of biochemistry, 2009-01, Vol.78 (1), p.177-204

2009

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Cryo-EM structure of anchorless RML prion reveals variations in shared motifs between distinct strains

Nature communications, 2022-07, Vol.13 (1), p.4005-4005, Article 4005

2022

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Cryo-EM of prion strains from the same genotype of host identifies conformational determinants

PLoS pathogens, 2022-11, Vol.18 (11), p.e1010947-e1010947

2022

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Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange

Nature structural & molecular biology, 2011-04, Vol.18 (4), p.504

2011

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Efficient uptake and dissemination of scrapie prion protein by astrocytes and fibroblasts from adult hamster brain

PloS one, 2015-01, Vol.10 (1), p.e0115351-e0115351

2015

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PrP Knockout Cells Expressing Transmembrane PrP Resist Prion Infection

Journal of virology, 2017-01, Vol.91 (2)

2017

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Effect of Glycans and the Glycophosphatidylinositol Anchor on Strain Dependent Conformations of Scrapie Prion Protein: Improved Purifications and Infrared Spectra

Biochemistry (Easton), 2011-05, Vol.50 (21), p.4479-4490

2011

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Characterization of intracellular dynamics of inoculated PrP-res and newly generated PrPSc during early stage prion infection in Neuro2a cells

Virology (New York, N.Y.), 2014-02, Vol.450, p.324-335

2014

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Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC

PloS one, 2012-11, Vol.7 (11), p.e48969-e48969

2012

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Prions and their partners in crime

Nature, 2006-10, Vol.443 (7113), p.803-810

2006

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Effect of Glycosylphosphatidylinositol Anchor-dependent and -independent Prion Protein Association with Model Raft Membranes on Conversion to the Protease-resistant Isoform

The Journal of biological chemistry, 2003-04, Vol.278 (17), p.14883-14892

2003

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Isolation of Novel Synthetic Prion Strains by Amplification in Transgenic Mice Coexpressing Wild-Type and Anchorless Prion Proteins

Journal of Virology, 2012-11, Vol.86 (21), p.11763-11778

2012

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Specific biarsenical labeling of cell surface proteins allows fluorescent- and biotin-tagging of amyloid precursor protein and prion proteins

Molecular biology of the cell, 2009-01, Vol.20 (1), p.233-244

2009

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GPI anchoring facilitates propagation and spread of misfolded Sup35 aggregates in mammalian cells

The EMBO journal, 2010-02, Vol.29 (4), p.782-794

2010

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Mouse-Adapted Scrapie Infection of SN56 Cells: Greater Efficiency with Microsome-Associated versus Purified PrP-res

Journal of Virology, 2006-03, Vol.80 (5), p.2106-2117

2006

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Inhibition of Protease-Resistant Prion Protein Accumulation In Vitro by Curcumin

Journal of Virology, 2003-05, Vol.77 (9), p.5499-5502

2003

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Effects of FlAsH/Tetracysteine (TC) Tag on PrP Proteolysis and PrPres Formation by TC-Scanning

Chembiochem : a European journal of chemical biology, 2013-09, Vol.14 (13), p.1597-1610

2013

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Hemin Interactions and Alterations of the Subcellular Localization of Prion Protein

The Journal of biological chemistry, 2007-12, Vol.282 (50), p.36525-36533

2007

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Inhibition of Protease-Resistant Prion Protein Formation in a Transformed Deer Cell Line Infected with Chronic Wasting Disease

Journal of Virology, 2006-01, Vol.80 (2), p.596-604

2006

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Characterization of intracellular dynamics of inoculated PrP-res and newly generated PrP(Sc) during early stage prion infection in Neuro2a cells

Virology (New York, N.Y.), 2014-02, Vol.450-451, p.324-335

2014

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Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrPSc) into contiguous membranes

The EMBO journal, 2002-03, Vol.21 (5), p.1031-1040

2002

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New Inhibitors of Scrapie-Associated Prion Protein Formation in a Library of 2,000 Drugs and Natural Products

Journal of Virology, 2003-10, Vol.77 (19), p.10288-10294

2003

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Uptake and Neuritic Transport of Scrapie Prion Protein Coincident with Infection of Neuronal Cells

The Journal of neuroscience, 2005-05, Vol.25 (21), p.5207-5216

2005

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Glycosylphosphatidylinositol Anchoring Directs the Assembly of Sup35NM Protein into Non-fibrillar, Membrane-bound Aggregates

The Journal of biological chemistry, 2014-05, Vol.289 (18), p.12245-12263

2014

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High-resolution structure and strain comparison of infectious mammalian prions

Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions

Cryo-EM structure of anchorless RML prion reveals variations in shared motifs between distinct strains

Cryo-EM of prion strains from the same genotype of host identifies conformational determinants

Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange

Efficient uptake and dissemination of scrapie prion protein by astrocytes and fibroblasts from adult hamster brain

PrP Knockout Cells Expressing Transmembrane PrP Resist Prion Infection

Effect of Glycans and the Glycophosphatidylinositol Anchor on Strain Dependent Conformations of Scrapie Prion Protein: Improved Purifications and Infrared Spectra

Characterization of intracellular dynamics of inoculated PrP-res and newly generated PrPSc during early stage prion infection in Neuro2a cells

Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC

Prions and their partners in crime

Effect of Glycosylphosphatidylinositol Anchor-dependent and -independent Prion Protein Association with Model Raft Membranes on Conversion to the Protease-resistant Isoform

Isolation of Novel Synthetic Prion Strains by Amplification in Transgenic Mice Coexpressing Wild-Type and Anchorless Prion Proteins

Specific biarsenical labeling of cell surface proteins allows fluorescent- and biotin-tagging of amyloid precursor protein and prion proteins

GPI anchoring facilitates propagation and spread of misfolded Sup35 aggregates in mammalian cells

Mouse-Adapted Scrapie Infection of SN56 Cells: Greater Efficiency with Microsome-Associated versus Purified PrP-res

Inhibition of Protease-Resistant Prion Protein Accumulation In Vitro by Curcumin

Effects of FlAsH/Tetracysteine (TC) Tag on PrP Proteolysis and PrPres Formation by TC-Scanning

Hemin Interactions and Alterations of the Subcellular Localization of Prion Protein

Inhibition of Protease-Resistant Prion Protein Formation in a Transformed Deer Cell Line Infected with Chronic Wasting Disease

Characterization of intracellular dynamics of inoculated PrP-res and newly generated PrP(Sc) during early stage prion infection in Neuro2a cells

Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrPSc) into contiguous membranes

New Inhibitors of Scrapie-Associated Prion Protein Formation in a Library of 2,000 Drugs and Natural Products

Uptake and Neuritic Transport of Scrapie Prion Protein Coincident with Infection of Neuronal Cells

Glycosylphosphatidylinositol Anchoring Directs the Assembly of Sup35NM Protein into Non-fibrillar, Membrane-bound Aggregates

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