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Pyridazinoquinolinetriones as NMDA Glycine-Site Antagonists with Oral Antinociceptive Activity in a Model of Neuropathic Pain

Journal of medicinal chemistry, 2007-06, Vol.50 (13), p.3113-3131

2007

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Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents

Journal of medicinal chemistry, 1989-12, Vol.32 (12), p.2561-2573

1989

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Synthesis of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5h )-triones as NMDA glycine-site antagonists

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (20), p.3553-3556

2003

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Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies

Stroke (1970), 1997-06, Vol.28 (6), p.1255-1263

1997

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Synthesis and activity of spiroisoindolines as novel noncompetitive NMDA antagonists

Bioorganic & medicinal chemistry letters, 1993, Vol.3 (1), p.55-60

1993

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Pyridazino[4,5-b]quinolinediones: Novel glycine/N-methyl-D-aspartate antagonists for the treatment of stroke

Journal of heterocyclic chemistry, 1998-09, Vol.35 (5), p.1171-1186

Bare, Thomas M.

1998

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Salicylamide derivatives related to medroxalol with .alpha.- and .beta.-adrenergic antagonist and antihypertensive activity

Journal of medicinal chemistry, 1981-03, Vol.24 (3), p.327-336

1981

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Perhydroindan derivatives. XI. The 7-methoxyhexahydrofluorene system

Journal of organic chemistry, 1969-07, Vol.34 (7), p.2209-2217

1969

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Extent of bond formation in the transition state for alkylation at nitrogen and at carbon

Journal of organic chemistry, 1972-04, Vol.37 (7), p.997-1002

1972

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Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/nmda antagonist: An in vivo three-dimensional diffusion-weighted MR microscopy study

Journal of magnetic resonance imaging, 1997-07, Vol.7 (4), p.739-744

1997

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Chemistry of carbanions. XVI. Stereochemistry of alkylation of the 1-acetyl and 1-cyano derivatives of 4-tert-butylcyclohexane

Journal of organic chemistry, 1968-03, Vol.33 (3), p.943-949

1968

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Synthesis of Nitrocyanomethyl Biphenyls, Diphenylmethanes, and Diphenyl Ethers

Journal of chemical and engineering data, 1966-04, Vol.11 (2), p.270-271

1966

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ChemInform Abstract: Pyridazino[4,5-b]quinolinediones: Novel Glycine/N-Methyl-D-aspartate Antagonists for the Treatment of Stroke

ChemInform, 1999-03, Vol.30 (9), p.no-no

Bare, Thomas M.

1999

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Chapter 2 Anxiolytics and Sedative-Hypnotics

Annual Reports in Medicinal Chemistry, 1987, Vol.22, p.11-20

1987

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Expression and function of voltage gated proton channels (Hv1) in MDA-MB-231 cells

PloS one, 2020-05, Vol.15 (5), p.e0227522

2020

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Toward harmonizing ecotoxicity characterization in life cycle impact assessment

Environmental toxicology and chemistry, 2018-12, Vol.37 (12), p.2955-2971

2018

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Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society

Epilepsy currents, 2016-01, Vol.16 (1), p.48-61

2016

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β-Adrenergic induced SR Ca2+ leak is mediated by an Epac-NOS pathway

Journal of molecular and cellular cardiology, 2017-07, Vol.108, p.8-16

2017

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Identification of the active complex for CO oxidation over single-atom Ir-on-MgAl2O4 catalysts

Nature catalysis, 2018-12, Vol.2 (2), p.149-156

2018

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Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study

Lancet neurology, 2020-09, Vol.19 (9), p.748-757

2020

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Understanding Degradation Mechanisms in SrIrO3 Oxygen Evolution Electrocatalysts: Chemical and Structural Microscopy at the Nanoscale

Advanced functional materials, 2021-08, Vol.31 (34), p.n/a

2021

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Occludin stalls HCV particle dynamics apart from hepatocyte tight junctions, promoting virion internalization

Hepatology (Baltimore, Md.), 2022-10, Vol.76 (4), p.1164-1179

2022

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Expanding Beyond the Micropore: Active-Site Engineering in Hierarchical Architectures for Beckmann Rearrangement

ACS catalysis, 2015-11, Vol.5 (11), p.6587-6593

2015

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Global guidance on environmental life cycle impact assessment indicators: progress and case study

The international journal of life cycle assessment, 2016-03, Vol.21 (3), p.429-442

2016

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Imaging-based target volume reduction in chemoradiotherapy for locally advanced non-small-cell lung cancer (PET-Plan): a multicentre, open-label, randomised, controlled trial

The lancet oncology, 2020-04, Vol.21 (4), p.581-592

2020

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Pyridazinoquinolinetriones as NMDA Glycine-Site Antagonists with Oral Antinociceptive Activity in a Model of Neuropathic Pain

Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents

Synthesis of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5h )-triones as NMDA glycine-site antagonists

Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies

Synthesis and activity of spiroisoindolines as novel noncompetitive NMDA antagonists

Pyridazino[4,5-b]quinolinediones: Novel glycine/N-methyl-D-aspartate antagonists for the treatment of stroke

Salicylamide derivatives related to medroxalol with .alpha.- and .beta.-adrenergic antagonist and antihypertensive activity

Perhydroindan derivatives. XI. The 7-methoxyhexahydrofluorene system

Extent of bond formation in the transition state for alkylation at nitrogen and at carbon

Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/nmda antagonist: An in vivo three-dimensional diffusion-weighted MR microscopy study

Chemistry of carbanions. XVI. Stereochemistry of alkylation of the 1-acetyl and 1-cyano derivatives of 4-tert-butylcyclohexane

Synthesis of Nitrocyanomethyl Biphenyls, Diphenylmethanes, and Diphenyl Ethers

ChemInform Abstract: Pyridazino[4,5-b]quinolinediones: Novel Glycine/N-Methyl-D-aspartate Antagonists for the Treatment of Stroke

Chapter 2 Anxiolytics and Sedative-Hypnotics

Expression and function of voltage gated proton channels (Hv1) in MDA-MB-231 cells

Toward harmonizing ecotoxicity characterization in life cycle impact assessment

Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society

β-Adrenergic induced SR Ca2+ leak is mediated by an Epac-NOS pathway

Identification of the active complex for CO oxidation over single-atom Ir-on-MgAl2O4 catalysts

Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study

Understanding Degradation Mechanisms in SrIrO3 Oxygen Evolution Electrocatalysts: Chemical and Structural Microscopy at the Nanoscale

Occludin stalls HCV particle dynamics apart from hepatocyte tight junctions, promoting virion internalization

Expanding Beyond the Micropore: Active-Site Engineering in Hierarchical Architectures for Beckmann Rearrangement

Global guidance on environmental life cycle impact assessment indicators: progress and case study

Imaging-based target volume reduction in chemoradiotherapy for locally advanced non-small-cell lung cancer (PET-Plan): a multicentre, open-label, randomised, controlled trial

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