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Structure-activity relationships and mode of action of 5-mercapto-substituted oligo- and polynucleotides as antitemplates inhibiting replication of human immunodeficiency virus type 1

Antimicrobial Agents and Chemotherapy, 1992-01, Vol.36 (1), p.108-114

1992

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Effect of increasing thiolation of the polycytidylic acid strand of poly I:poly C on the α, β and γ interferon-inducing properties, antiviral and antiproliferative activities

Antiviral research, 2004-12, Vol.64 (3), p.171-177

2004

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Anti-herpes simplex virus activity of 5-substituted 2-pyrimidinone nucleosides

Antimicrobial Agents and Chemotherapy, 1989-03, Vol.33 (3), p.340-344

1989

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Synthesis and testing of quinone-based bis(2,2-dimethyl-1-aziridinyl)phosphinyl carbamates as radiation-potentiating antitumor agents

Journal of medicinal chemistry, 1988-06, Vol.31 (6), p.1240-1244

1988

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Modified Telomeric Repeat Amplification Protocol: A Quantitative Radioactive Assay for Telomerase without Using Electrophoresis

Analytical biochemistry, 2000-06, Vol.282 (1), p.80-88

2000

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Synthesis of new nucleoside phosphoraziridines as potential site-directed antineoplastic agents

Journal of medicinal chemistry, 1990-09, Vol.33 (9), p.2596-2602

1990

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Synthesis of potential dual-acting radiation sensitizer antineoplastic agents: 2,2-dimethylphosphoraziridines containing 2-nitroimidazoles or other electron-affinic moieties

Journal of medicinal chemistry, 1991-04, Vol.34 (4), p.1400-1407

1991

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Synthesis and antitumor activity of 1,2-dihydro-1-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-2-oxo-5-methylpyrazine 4-oxide, a structural analog of thymidine

Journal of medicinal chemistry, 1977-03, Vol.20 (3), p.458-460

1977

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Synthesis of 5-selenium-substituted uracil derivatives. Inhibition of thymidylate synthetase by 5-hydroseleno-2'-deoxyuridylate

Journal of medicinal chemistry, 1979-06, Vol.22 (6), p.618-621

1979

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Synthesis and inhibition analysis of 2(4)-imino-4(2)-amino-2,4-dideoxyriboflavin, a dual antagonist of riboflavin and folinic acid

Journal of medicinal chemistry, 1977-02, Vol.20 (2), p.312-314

1977

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Synthesis and properties of bis(2,2-dimethylaziridinyl)phosphinic amides: a series of new antineoplastic agents

Journal of medicinal chemistry, 1985-11, Vol.28 (11), p.1685-1691

1985

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Plasma clearance and tissue distribution of partially thiolated polycytidylic acid and its degradation products in rodents

Cancer research (Chicago, Ill.), 1984-10, Vol.44 (10), p.4602-4606

1984

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Inhibition of DNA polymerase alpha from leukemic and normal human cells by partially thiolated human deoxyribonucleic acids

Cancer biochemistry biophysics, 1985-12, Vol.8 (2), p.85

1985

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Synthesis of new bis(1-aziridinyl) phosphinate alkylating agents containing O-phenyl N-phenylcarbamate side chains

Journal of medicinal chemistry, 1973-04, Vol.16 (4), p.391-394

1973

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Effects of 5-mercapto-2'-deoxyuridine on the incorporation of nucleosides into RNA and DNA in a primary lymphocyte culture system

Cancer research (Chicago, Ill.), 1976-09, Vol.36 (9 pt.1), p.3284-3293

1976

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Differential Effects of 5-Methylmercapto-2′-Deoxyuridine on the Replication of Herpes Simplex Virus Type 1 in Two Cell Systems

Antimicrobial Agents and Chemotherapy, 1976-10, Vol.10 (4), p.682-686

1976

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Comparative chemical and biological studies of four prototype phosphoraziridine antineoplastic agents

Biochemical pharmacology, 1991-03, Vol.41 (6), p.885-892

1991

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Antiviral Activity of Partially Thiolated Polynucleotides

Molecular pharmacology, 1975-01, Vol.11 (1), p.61-69

1975

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Enzymatic Studies Relating to the Mode of Action of 5-Mercapto-2'-deoxyuridine

Molecular pharmacology, 1970-11, Vol.6 (6), p.621-630

1970

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Simplified synthesis of 5-mercaptouracil riboside derivatives

Journal of organic chemistry, 1982-04, Vol.47 (9), p.1769-1772

1982

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Consideration of chemical reaction mechanisms in relationship to the biological action of “dual antagonists”

Biochemical pharmacology, 1962-03, Vol.11 (3), p.256-260

Bardos, T.J.

1962

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Further studies on the effects of various in vivo and in vitro factors on the priming and template activities of DNA isolates in the DNA and RNA polymerase systems

Cancer research (Chicago, Ill.), 1970-04, Vol.30 (4), p.952-959

1970

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New Alkylating Agents Derived from Diaziridine

Journal of medicinal chemistry, 1967-01, Vol.10 (1), p.101-104

1967

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A systematic investigation of the presence of growth-inhibitory substances in animal tissues

Cancer research (Chicago, Ill.), 1968-08, Vol.28 (8), p.1620-1630

1968

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Alterations of some macromolecular and biochemical properties of calf thymus DNA caused by "dual antagonists" and nitrogen mustard

Cancer research (Chicago, Ill.), 1967-07, Vol.27 (7), p.1248

1967

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Structure-activity relationships and mode of action of 5-mercapto-substituted oligo- and polynucleotides as antitemplates inhibiting replication of human immunodeficiency virus type 1

Effect of increasing thiolation of the polycytidylic acid strand of poly I:poly C on the α, β and γ interferon-inducing properties, antiviral and antiproliferative activities

Anti-herpes simplex virus activity of 5-substituted 2-pyrimidinone nucleosides

Synthesis and testing of quinone-based bis(2,2-dimethyl-1-aziridinyl)phosphinyl carbamates as radiation-potentiating antitumor agents

Modified Telomeric Repeat Amplification Protocol: A Quantitative Radioactive Assay for Telomerase without Using Electrophoresis

Synthesis of new nucleoside phosphoraziridines as potential site-directed antineoplastic agents

Synthesis of potential dual-acting radiation sensitizer antineoplastic agents: 2,2-dimethylphosphoraziridines containing 2-nitroimidazoles or other electron-affinic moieties

Synthesis and antitumor activity of 1,2-dihydro-1-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-2-oxo-5-methylpyrazine 4-oxide, a structural analog of thymidine

Synthesis of 5-selenium-substituted uracil derivatives. Inhibition of thymidylate synthetase by 5-hydroseleno-2'-deoxyuridylate

Synthesis and inhibition analysis of 2(4)-imino-4(2)-amino-2,4-dideoxyriboflavin, a dual antagonist of riboflavin and folinic acid

Synthesis and properties of bis(2,2-dimethylaziridinyl)phosphinic amides: a series of new antineoplastic agents

Plasma clearance and tissue distribution of partially thiolated polycytidylic acid and its degradation products in rodents

Inhibition of DNA polymerase alpha from leukemic and normal human cells by partially thiolated human deoxyribonucleic acids

Synthesis of new bis(1-aziridinyl) phosphinate alkylating agents containing O-phenyl N-phenylcarbamate side chains

Effects of 5-mercapto-2'-deoxyuridine on the incorporation of nucleosides into RNA and DNA in a primary lymphocyte culture system

Differential Effects of 5-Methylmercapto-2′-Deoxyuridine on the Replication of Herpes Simplex Virus Type 1 in Two Cell Systems

Comparative chemical and biological studies of four prototype phosphoraziridine antineoplastic agents

Antiviral Activity of Partially Thiolated Polynucleotides

Enzymatic Studies Relating to the Mode of Action of 5-Mercapto-2'-deoxyuridine

Simplified synthesis of 5-mercaptouracil riboside derivatives

Consideration of chemical reaction mechanisms in relationship to the biological action of “dual antagonists”

Further studies on the effects of various in vivo and in vitro factors on the priming and template activities of DNA isolates in the DNA and RNA polymerase systems

New Alkylating Agents Derived from Diaziridine

A systematic investigation of the presence of growth-inhibitory substances in animal tissues

Alterations of some macromolecular and biochemical properties of calf thymus DNA caused by "dual antagonists" and nitrogen mustard

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