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Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function

Cell reports (Cambridge), 2022-01, Vol.38 (2), p.110090-110090, Article 110090

2022

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Gastrointestinal Immunity and Alpha-Synuclein

Journal of Parkinson's disease, 2019-01, Vol.9 (s2), p.S313-S322

2019

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A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity

Journal of innate immunity, 2017-01, Vol.9 (5), p.456-463

2017

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Identification of SSRI-evoked antidepressant sensory signals by decoding vagus nerve activity

Scientific reports, 2021-10, Vol.11 (1), p.21130-21130, Article 21130

2021

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Squalamine reverses age-associated changes of firing patterns of myenteric sensory neurons and vagal fibres

Communications biology, 2024-01, Vol.7 (1), p.80-80, Article 80

2024

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Targeting neurons in the gastrointestinal tract to treat Parkinson's disease

Clinical parkinsonism & related disorders, 2019-01, Vol.1, p.2-7

2019

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Rapid Head Cooling Initiated Coincident With Cardiopulmonary Resuscitation Improves Success of Defibrillation and Post-Resuscitation Myocardial Function in a Porcine Model of Prolonged Cardiac Arrest

Journal of the American College of Cardiology, 2008-05, Vol.51 (20), p.1988-1990

2008

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Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic

Natural product reports, 2022-04, Vol.39 (4), p.742-753

2022

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Reorganization of the outer layer of a model of the plasma membrane induced by a neuroprotective aminosterol

Colloids and surfaces, B, Biointerfaces, 2023-02, Vol.222, p.113115-113115, Article 113115

2023

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Local Brain Temperature Reduction Through Intranasal Cooling With the RhinoChill Device Preliminary Safety Data in Brain-Injured Patients

Stroke (1970), 2011-08, Vol.42 (8), p.2164-2169

2011

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Intranasal Perfluorochemical Spray for Preferential Brain Cooling in Sheep

Neurocritical care, 2008-06, Vol.8 (3), p.437-447

2008

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Intra-Arrest Transnasal Evaporative Cooling: A Randomized, Prehospital, Multicenter Study (PRINCE: Pre-ROSC IntraNasal Cooling Effectiveness)

Circulation (New York, N.Y.), 2010-08, Vol.122 (7), p.729-736

2010

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A novel, centrally acting mammalian aminosterol, ENT-03, induces weight loss in obese and lean rodents

Diabetes, obesity & metabolism, 2024-09

2024

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854-P: ENT-03, a Centrally Acting Endogenous Spermine Bile Acid with PTP1B Inhibitory Activity, Has Potent Effects on Metabolism and Weight in a Mouse Model of Diet-Induced Obesity (DIO)

Diabetes (New York, N.Y.), 2023-06, Vol.72 (Supplement_1), p.1

2023

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Making biological membrane resistant to the toxicity of misfolded protein oligomers: a lesson from trodusquemine

Nanoscale, 2020-11, Vol.12 (44), p.22596-22614

2020

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Multistep Inhibition of α‑Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

ACS chemical biology, 2018-08, Vol.13 (8), p.2308-2319

2018

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Asymmetric synthesis of ENT-03, the predicted mammalian ortholog of the dog fish shark aminosterol trodusquemine (MSI-1436)

Tetrahedron letters, 2024-09, Vol.148, p.155220, Article 155220

2024

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Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes

Journal of medicinal chemistry, 2023-07, Vol.66 (14), p.9519-9536

2023

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Response to Letter by Albin Regarding Article, “Local Brain Temperature Reduction via Intranasal Cooling With the RhinoChill Device: Preliminary Safety Data in Brain-Injured Patients”

Stroke (1970), 2012-01, Vol.43 (1)

2012

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Quantitative Measurement of the Affinity of Toxic and Nontoxic Misfolded Protein Oligomers for Lipid Bilayers and of its Modulation by Lipid Composition and Trodusquemine

ACS chemical neuroscience, 2021-09, Vol.12 (17), p.3189-3202

2021

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Impact of Embolization During Coronary Artery Bypass Grafting on Outcome and Length of Stay

The Annals of thoracic surgery, 1997-04, Vol.63 (4), p.998-1002

1997

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Posterior Distribution of Infarcts in Strokes Related to Cardiac Operations

The Annals of thoracic surgery, 1998-06, Vol.65 (6), p.1656-1659

1998

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Squalamine Restores the Function of the Enteric Nervous System in Mouse Models of Parkinson’s Disease

Journal of Parkinson's disease, 2020-01, Vol.10 (4), p.1477-1491

2020

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Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function

Gastrointestinal Immunity and Alpha-Synuclein

A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity

Identification of SSRI-evoked antidepressant sensory signals by decoding vagus nerve activity

Squalamine reverses age-associated changes of firing patterns of myenteric sensory neurons and vagal fibres

Targeting neurons in the gastrointestinal tract to treat Parkinson's disease

Rapid Head Cooling Initiated Coincident With Cardiopulmonary Resuscitation Improves Success of Defibrillation and Post-Resuscitation Myocardial Function in a Porcine Model of Prolonged Cardiac Arrest

Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic

Reorganization of the outer layer of a model of the plasma membrane induced by a neuroprotective aminosterol

Local Brain Temperature Reduction Through Intranasal Cooling With the RhinoChill Device Preliminary Safety Data in Brain-Injured Patients

Intranasal Perfluorochemical Spray for Preferential Brain Cooling in Sheep

Intra-Arrest Transnasal Evaporative Cooling: A Randomized, Prehospital, Multicenter Study (PRINCE: Pre-ROSC IntraNasal Cooling Effectiveness)

Oral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease : A Randomized Controlled Trial

A novel, centrally acting mammalian aminosterol, ENT-03, induces weight loss in obese and lean rodents

854-P: ENT-03, a Centrally Acting Endogenous Spermine Bile Acid with PTP1B Inhibitory Activity, Has Potent Effects on Metabolism and Weight in a Mouse Model of Diet-Induced Obesity (DIO)

Making biological membrane resistant to the toxicity of misfolded protein oligomers: a lesson from trodusquemine

Multistep Inhibition of α‑Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

Asymmetric synthesis of ENT-03, the predicted mammalian ortholog of the dog fish shark aminosterol trodusquemine (MSI-1436)

Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes

Response to Letter by Albin Regarding Article, “Local Brain Temperature Reduction via Intranasal Cooling With the RhinoChill Device: Preliminary Safety Data in Brain-Injured Patients”

Quantitative Measurement of the Affinity of Toxic and Nontoxic Misfolded Protein Oligomers for Lipid Bilayers and of its Modulation by Lipid Composition and Trodusquemine

Impact of Embolization During Coronary Artery Bypass Grafting on Outcome and Length of Stay

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers

Posterior Distribution of Infarcts in Strokes Related to Cardiac Operations

Squalamine Restores the Function of the Enteric Nervous System in Mouse Models of Parkinson’s Disease

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