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Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors

Antimicrobial Agents and Chemotherapy, 2008-08, Vol.52 (8), p.2806-2812

2008

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Novel oxazolidinone–quinolone hybrid antimicrobials

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (23), p.4213-4216

2003

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Chemical Oxidation of 2,4-Diamino-pyrrolo[2,3-d]pyrimidines

Journal of organic chemistry, 1998-10, Vol.63 (21), p.7542-7546

1998

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Preclinical evaluation of anti-inflammatory activities of the novel pyrrolopyrimidine PNU-142731A, a potential treatment for asthma

The Journal of pharmacology and experimental therapeutics, 1999-07, Vol.290 (1), p.188

1999

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Synthesis of Novel 2,4-Diaminopyrrolo[2,3-d]pyrimidines with Antioxidant, Neuroprotective, and Antiasthma Activity

Journal of medicinal chemistry, 1995-10, Vol.38 (21), p.4161-4163

1995

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Synthesis of 2,4-Di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indoles, Including Antiasthma Clinical Candidate PNU-142731A

Organic process research & development, 2001-03, Vol.5 (2), p.144-151

2001

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Bioactivation of 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) to Reactive Intermediates That Bind Covalently to Macromolecules and Produce Genotoxicity1

Chemical research in toxicology, 1996-11, Vol.9 (8), p.1230-1239

1996

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Novel oxazolidinone-quinolone hybrid antimicrobials: Antibacterial agents: solutions for the evolving problems of resistance

Bioorganic & medicinal chemistry letters, 2003, Vol.13 (23), p.4213-4216

2003

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Synthesis of 2,4-diaminopyrrolo[2,3-d]pyrimidines via thermal fischer indolization. Pyrazole formation with ytterbium triflate catalysis

Journal of heterocyclic chemistry, 2000-11, Vol.37 (6), p.1471-1477

2000

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In vitro and in vivo biotransformation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-D]pyrimidine (U-89843) in the rat

Drug metabolism and disposition, 1996-02, Vol.24 (2), p.187

1996

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Bioactivation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) to reactive intermediates that bind covalently to macromolecules and produce genotoxicity

Chemical research in toxicology, 1996-12, Vol.9 (8), p.1230-1239

1996

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Bioactivation of 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7 H -pyrrolo[2,3- d ]pyrimidine (U-89843) to Reactive Intermediates That Bind Covalently to Macromolecules and Produce Genotoxicity 1

Chemical research in toxicology, 1996-01, Vol.9 (8), p.1230-1239

1996

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ChemInform Abstract: Synthesis of 2,4-Diaminopyrrolo[2,3-d]pyrimidines via Thermal Fischer Indolization. Pyrazole Formation with Ytterbium Triflate Catalysis

ChemInform, 2001-05, Vol.32 (21), p.no-no

2001

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Four Generations of Pyrrolopyrimidines

ChemInform, 2002-10, Vol.33 (42), p.266-266

2002

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Automated Detection of Glaucoma With Interpretable Machine Learning Using Clinical Data and Multimodal Retinal Images

American journal of ophthalmology, 2021-11, Vol.231, p.154-169

2021

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Treatment Outcomes in the Primary Tube Versus Trabeculectomy Study after 1 Year of Follow-up

Ophthalmology (Rochester, Minn.), 2018-05, Vol.125 (5), p.650-663

2018

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Treatment Outcomes in the Primary Tube Versus Trabeculectomy Study after 5 Years of Follow-up

Ophthalmology (Rochester, Minn.), 2022-12, Vol.129 (12), p.1344-1356

2022

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Evidenced-based comparison of aqueous shunts

Current opinion in ophthalmology, 2013-03, Vol.24 (2), p.87-95

2013

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Postoperative Complications in the Primary Tube Versus Trabeculectomy Study During 5 Years of Follow-up

Ophthalmology (Rochester, Minn.), 2022-12, Vol.129 (12), p.1357-1367

2022

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Management of patients with combined glaucoma and corneal transplant surgery

Eye (London), 2009-10, Vol.23 (10), p.1972-1979

2009

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Automated detection of glaucoma with interpretable machine learning using clinical data and multi-modal retinal images

American journal of ophthalmology, 2021-05, Vol.231, p.154-169

2021

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Visual Field Outcomes in the Primary Tube Versus Trabeculectomy Study

Ophthalmology (Rochester, Minn.), 2024-04

2024

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Forme fruste anterior segment dysgenesis

British journal of ophthalmology, 2011-12, Vol.95 (12), p.1756-1757

2011

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The Tube Versus Trabeculectomy Study: interpretation of results and application to clinical practice

Current opinion in ophthalmology, 2012-03, Vol.23 (2), p.118-126

2012

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Outcomes of Glaucoma Reoperations in the Primary Tube Versus Trabeculectomy Study

Ophthalmology. Glaucoma, 2023-07, Vol.6 (4), p.422-431

2023

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Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors

Novel oxazolidinone–quinolone hybrid antimicrobials

Chemical Oxidation of 2,4-Diamino-pyrrolo[2,3-d]pyrimidines

Preclinical evaluation of anti-inflammatory activities of the novel pyrrolopyrimidine PNU-142731A, a potential treatment for asthma

Synthesis of Novel 2,4-Diaminopyrrolo[2,3-d]pyrimidines with Antioxidant, Neuroprotective, and Antiasthma Activity

Synthesis of 2,4-Di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indoles, Including Antiasthma Clinical Candidate PNU-142731A

Bioactivation of 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) to Reactive Intermediates That Bind Covalently to Macromolecules and Produce Genotoxicity1

Novel oxazolidinone-quinolone hybrid antimicrobials: Antibacterial agents: solutions for the evolving problems of resistance

Synthesis of 2,4-diaminopyrrolo[2,3-d]pyrimidines via thermal fischer indolization. Pyrazole formation with ytterbium triflate catalysis

In vitro and in vivo biotransformation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-D]pyrimidine (U-89843) in the rat

Bioactivation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) to reactive intermediates that bind covalently to macromolecules and produce genotoxicity

Bioactivation of 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7 H -pyrrolo[2,3- d ]pyrimidine (U-89843) to Reactive Intermediates That Bind Covalently to Macromolecules and Produce Genotoxicity 1

ChemInform Abstract: Synthesis of 2,4-Diaminopyrrolo[2,3-d]pyrimidines via Thermal Fischer Indolization. Pyrazole Formation with Ytterbium Triflate Catalysis

Four Generations of Pyrrolopyrimidines

Automated Detection of Glaucoma With Interpretable Machine Learning Using Clinical Data and Multimodal Retinal Images

Treatment Outcomes in the Primary Tube Versus Trabeculectomy Study after 1 Year of Follow-up

Treatment Outcomes in the Primary Tube Versus Trabeculectomy Study after 5 Years of Follow-up

Evidenced-based comparison of aqueous shunts

Postoperative Complications in the Primary Tube Versus Trabeculectomy Study During 5 Years of Follow-up

Management of patients with combined glaucoma and corneal transplant surgery

Automated detection of glaucoma with interpretable machine learning using clinical data and multi-modal retinal images

Visual Field Outcomes in the Primary Tube Versus Trabeculectomy Study

Forme fruste anterior segment dysgenesis

The Tube Versus Trabeculectomy Study: interpretation of results and application to clinical practice

Outcomes of Glaucoma Reoperations in the Primary Tube Versus Trabeculectomy Study

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