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Discovery and development of first in class antifungal caspofungin (CANCIDAS®)-A case study

Natural product reports, 2014-01, Vol.31 (1), p.15-34

2014

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Bifunctional Small Molecules Enhance Neutrophil Activities Against Aspergillus fumigatus in vivo and in vitro

Frontiers in immunology, 2019-04, Vol.10, p.644-644

2019

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Preclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel Echinocandin

Antimicrobial agents and chemotherapy, 2016-11, Vol.60 (11), p.6872-6879

2016

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The First Stereoselective Total Synthesis of Quinine

Journal of the American Chemical Society, 2001-04, Vol.123 (14), p.3239-3242

2001

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The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species

Journal of lipid research, 2011-06, Vol.52 (6), p.1150-1161

2011

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Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor

Bioorganic & medicinal chemistry letters, 2021-01, Vol.32, p.127661-127661, Article 127661

2021

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Development of Novel Immunoprophylactic Agents against Multidrug-Resistant Gram-Negative Bacterial Infections

Antimicrobial agents and chemotherapy, 2021-10, Vol.65 (11), p.e0098521-e0098521

2021

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Novel N-Arylpyrazolo[3,2-c]-Based Ligands for the Glucocorticoid Receptor: Receptor Binding and in Vivo Activity

Journal of medicinal chemistry, 2004-05, Vol.47 (10), p.2441-2452

2004

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11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice

The Journal of experimental medicine, 2005-08, Vol.202 (4), p.517-527

2005

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MK-5204: An orally active β-1,3-glucan synthesis inhibitor

Bioorganic & medicinal chemistry letters, 2020-09, Vol.30 (17), p.127357-127357, Article 127357

2020

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CTC-177, a novel drug–Fc conjugate, shows promise as an immunoprophylactic agent against multidrug-resistant Gram-negative bacterial infections

JAC-antimicrobial resistance, 2024-08, Vol.6 (4), p.dlae100

2024

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Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)

Bioorganic & medicinal chemistry letters, 2019-06, Vol.29 (11), p.1380-1385

2019

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Novel orally active inhibitors of β-1,3-glucan synthesis derived from enfumafungin

Bioorganic & medicinal chemistry letters, 2015-12, Vol.25 (24), p.5813-5818

2015

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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety

Bioorganic & medicinal chemistry letters, 2019-05, Vol.29 (10), p.1182-1186

2019

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Synthesis and biological evaluation of antifungal derivatives of enfumafungin as orally bioavailable inhibitors of β-1,3-glucan synthase

Bioorganic & medicinal chemistry letters, 2012-11, Vol.22 (22), p.6811-6816

2012

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Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (19), p.4359-4362

2005

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11 beta -HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature

Physiological genomics, 2013-01, Vol.45 (1), p.47-57

2013

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Phenylcyclobutyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3412-3416

2008

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11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature

Physiological genomics, 2013-01, Vol.45 (1), p.47-57

2013

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Section Review: Anti-infectives: Lipopeptide antifungal agents

Expert opinion on investigational drugs, 1994-02, Vol.3 (2), p.65-82

Balkovec, James M

1994

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On the use of the O-methylmandelate ester for establishment of absolute configuration of secondary alcohols

Journal of organic chemistry, 1986-06, Vol.51 (12), p.2370-2374

1986

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4-Methyl-5-phenyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3405-3411

2008

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Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

ACS medicinal chemistry letters, 2014-10, Vol.5 (10), p.1082-1087

2014

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Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome

Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (23), p.5266-5269

2005

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Synthesis and Antifungal Activity of Novel Cationic Pneumocandin Bo Derivatives

Journal of medicinal chemistry, 1994-01, Vol.37 (2), p.222-225

1994

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Discovery and development of first in class antifungal caspofungin (CANCIDAS®)-A case study

Bifunctional Small Molecules Enhance Neutrophil Activities Against Aspergillus fumigatus in vivo and in vitro

Preclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel Echinocandin

The First Stereoselective Total Synthesis of Quinine

The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species

Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor

Development of Novel Immunoprophylactic Agents against Multidrug-Resistant Gram-Negative Bacterial Infections

Novel N-Arylpyrazolo[3,2-c]-Based Ligands for the Glucocorticoid Receptor: Receptor Binding and in Vivo Activity

11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice

MK-5204: An orally active β-1,3-glucan synthesis inhibitor

CTC-177, a novel drug–Fc conjugate, shows promise as an immunoprophylactic agent against multidrug-resistant Gram-negative bacterial infections

Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)

Novel orally active inhibitors of β-1,3-glucan synthesis derived from enfumafungin

Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety

Synthesis and biological evaluation of antifungal derivatives of enfumafungin as orally bioavailable inhibitors of β-1,3-glucan synthase

Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1

11 beta -HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature

Phenylcyclobutyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I

11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature

Section Review: Anti-infectives: Lipopeptide antifungal agents

On the use of the O-methylmandelate ester for establishment of absolute configuration of secondary alcohols

4-Methyl-5-phenyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I

Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome

Synthesis and Antifungal Activity of Novel Cationic Pneumocandin Bo Derivatives

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