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Malignant A-to-I RNA editing by ADAR1 drives T cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing

Cell reports (Cambridge), 2024-02, Vol.43 (2), p.113704-113704, Article 113704

2024

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ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis

Cell stem cell, 2016-08, Vol.19 (2), p.177-191

2016

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Direct effect of bispecific anti-CD33×anti-CD64 antibody on proliferation and signaling in myeloid cells

Leukemia research, 2001-12, Vol.25 (12), p.1115-1125

2001

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ADAR1 Splicing Modulation As a Mechanism to Eradicate Immunologically Silent Leukemia Stem Cells

Blood, 2021-11, Vol.138 (Supplement 1), p.3321-3321

2021

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RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML

Cell stem cell, 2016-11, Vol.19 (5), p.599-612

2016

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Reversal of malignant ADAR1 splice isoform switching with Rebecsinib

Cell stem cell, 2023-03, Vol.30 (3), p.250-263.e6

2023

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Abstract 123: Molecular mechanisms of RNA and DNA editing in leukemic transformation of hemopoietic stem and progenitor cells

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.123-123

2023

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Inhibition of acute myeloid leukemia cell growth by mono-specific and bi-specific anti-CD33 × anti-CD64 antibodies

Leukemia research, 2004-08, Vol.28 (8), p.821-829

2004

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A Phase I/II Trial of the Combination of Azacitidine and Gemtuzumab Ozogamicin for Treatment of Relapsed Acute Myeloid Leukemia

Clinical lymphoma, myeloma and leukemia, 2018-05, Vol.18 (5), p.346-352.e5

2018

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Abstract 469: Selective targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.469-469

2020

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Abstract 3792: Imetelstat inhibits RNA-editing mediated myeloproliferative neoplasm stem cell self-renewal

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.3792-3792

2020

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Abstract 4865: Differential survival and self-renewal of LSC and HSC in aged and leukemic niches

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.4865-4865

2014

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Deregulation of Splicing in Pediatric Acute Myeloid Stem and Progenitor Cells

Blood, 2021-11, Vol.138 (Supplement 1), p.2227-2227

2021

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Abstract 3154: Assessing hematopoietic stem cell fitness within a nanobioreactor in microgravity

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.3154-3154

2022

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Abstract 263: RNA Editing ADAR1 Deaminase Activation Responsive (READAR) platforms for dynamic detection of clonal myeloproliferative neoplasm stem cell fitness

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.263-263

2024

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Abstract 3338: Pacritinib reduces human myeloid leukemia stem cell maintance in a defined niche

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.3338-3338

2016

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Telomerase Inhibition with Imetelstat Eradicates β-Catenin Activated Blast Crisis Chronic Myeloid Leukemia Stem Cells

Blood, 2016-12, Vol.128 (22), p.3065-3065

2016

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Decoding the RNA Editome of Normal Versus Malignant Progenitor Cell Aging Short Title: RNA Editing in Normal Aging and MDS/AML Stem Cells

Blood, 2016-12, Vol.128 (22), p.1519-1519

2016

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Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells

Cell reports. Medicine, 2023-03, Vol.4 (3), p.100962-100962, Article 100962

2023

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5-Azacytidine Augments the Cytotoxicity of Mylotarg toward AML Blasts In Vitro and In Vivo

Blood, 2007-11, Vol.110 (11), p.1835-1835

2007

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Abstract 219: Splicing inhibitors reduce human AML CD34+ cell survival and self-renewal during MDS/AML evolution in a leukemia stem cell supportive niche assay

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.219-219

2013

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Abstract 915: RNA processing signatures of normal versus malignant progenitor cell aging predict leukemia stem cell sensitivity to RNA splicing modulation

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.915-915

2016

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The inhibitory effect of anti-CD33 monoclonal antibodies on AML cell growth correlates with Syk and/or ZAP-70 expression

Experimental hematology, 2003-05, Vol.31 (5), p.363-371

2003

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The Pan-Bcl-2 Family Inhibitor 97C1 Targets Blast Crisis Chronic Myeloid Leukemia Stem Cells but Spares Normal Cord Blood Progenitor Cells

Blood, 2010-11, Vol.116 (21), p.516-516

2010

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Malignant A-to-I RNA editing by ADAR1 drives T cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing

ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis

Direct effect of bispecific anti-CD33×anti-CD64 antibody on proliferation and signaling in myeloid cells

ADAR1 Splicing Modulation As a Mechanism to Eradicate Immunologically Silent Leukemia Stem Cells

RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML

Reversal of malignant ADAR1 splice isoform switching with Rebecsinib

Abstract 123: Molecular mechanisms of RNA and DNA editing in leukemic transformation of hemopoietic stem and progenitor cells

Inhibition of acute myeloid leukemia cell growth by mono-specific and bi-specific anti-CD33 × anti-CD64 antibodies

A Phase I/II Trial of the Combination of Azacitidine and Gemtuzumab Ozogamicin for Treatment of Relapsed Acute Myeloid Leukemia

Abstract 469: Selective targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells

Abstract 3792: Imetelstat inhibits RNA-editing mediated myeloproliferative neoplasm stem cell self-renewal

A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition

Abstract 4865: Differential survival and self-renewal of LSC and HSC in aged and leukemic niches

Deregulation of Splicing in Pediatric Acute Myeloid Stem and Progenitor Cells

Abstract 3154: Assessing hematopoietic stem cell fitness within a nanobioreactor in microgravity

Abstract 263: RNA Editing ADAR1 Deaminase Activation Responsive (READAR) platforms for dynamic detection of clonal myeloproliferative neoplasm stem cell fitness

Abstract 3338: Pacritinib reduces human myeloid leukemia stem cell maintance in a defined niche

Telomerase Inhibition with Imetelstat Eradicates β-Catenin Activated Blast Crisis Chronic Myeloid Leukemia Stem Cells

Decoding the RNA Editome of Normal Versus Malignant Progenitor Cell Aging Short Title: RNA Editing in Normal Aging and MDS/AML Stem Cells

Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells

5-Azacytidine Augments the Cytotoxicity of Mylotarg toward AML Blasts In Vitro and In Vivo

Abstract 219: Splicing inhibitors reduce human AML CD34+ cell survival and self-renewal during MDS/AML evolution in a leukemia stem cell supportive niche assay

Abstract 915: RNA processing signatures of normal versus malignant progenitor cell aging predict leukemia stem cell sensitivity to RNA splicing modulation

The inhibitory effect of anti-CD33 monoclonal antibodies on AML cell growth correlates with Syk and/or ZAP-70 expression

The Pan-Bcl-2 Family Inhibitor 97C1 Targets Blast Crisis Chronic Myeloid Leukemia Stem Cells but Spares Normal Cord Blood Progenitor Cells

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