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Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans

Clinical pharmacology and therapeutics, 2015-06, Vol.97 (6), p.650-658

2015

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Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug-Drug Interactions

Clinical pharmacology and therapeutics, 2014-10, Vol.96 (4), p.498-507

2014

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Potent mechanism‐based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates

British journal of pharmacology, 2012-04, Vol.165 (8), p.2787-2798

2012

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Carboxylesterase 1 Polymorphism Impairs Oseltamivir Bioactivation in Humans

Clinical pharmacology and therapeutics, 2012-07, Vol.92 (1), p.68-71

2012

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Grapefruit Juice Inhibits the Metabolic Activation of Clopidogrel

Clinical pharmacology and therapeutics, 2014-03, Vol.95 (3), p.307-313

2014

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Mechanism-Based Inactivation of CYP2C8 by Gemfibrozil Occurs Rapidly in Humans

Clinical pharmacology and therapeutics, 2011-04, Vol.89 (4), p.579-586

2011

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The Effect of Gemfibrozil on Repaglinide Pharmacokinetics Persists for at Least 12 h After the Dose: Evidence for Mechanism‐based Inhibition of CYP2C8 In Vivo

Clinical pharmacology and therapeutics, 2008-09, Vol.84 (3), p.403-411

2008

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Gemfibrozil Is a Strong Inactivator of CYP2C8 in Very Small Multiple Doses

Clinical pharmacology and therapeutics, 2012-05, Vol.91 (5), p.846-855

2012

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Effects of Gemfibrozil and Atorvastatin on the Pharmacokinetics of Repaglinide in Relation to SLCO1B1 Polymorphism

Clinical pharmacology and therapeutics, 2008-10, Vol.84 (4), p.488-496

2008

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Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide

Diabetologia, 2003-03, Vol.46 (3), p.347-351

2003

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Gemfibrozil Impairs Imatinib Absorption and Inhibits the CYP2C8-Mediated Formation of Its Main Metabolite

Clinical pharmacology and therapeutics, 2013-09, Vol.94 (3), p.383-393

2013

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Gemfibrozil Markedly Increases the Plasma Concentrations of Montelukast: A Previously Unrecognized Role for CYP2C8 in the Metabolism of Montelukast

Clinical pharmacology and therapeutics, 2010-08, Vol.88 (2), p.223-230

2010

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Effects of Daily Ingestion of Cranberry Juice on the Pharmacokinetics of Warfarin, Tizanidine, and Midazolam-Probes of CYP2C9, CYP1A2, and CYP3A4

Clinical pharmacology and therapeutics, 2007-06, Vol.81 (6), p.833-839

2007

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The effects of intravenous lipid emulsion on hemodynamic recovery and myocardial cell mitochondrial function after bupivacaine toxicity in anesthetized pigs

Human & experimental toxicology, 2017-04, Vol.36 (4), p.365-375

2017

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Gemfibrozil considerably increases the plasma concentrations of rosiglitazone

Diabetologia, 2003-10, Vol.46 (10), p.1319-1323

2003

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Developmental pharmacokinetics of ciclosporin – a population pharmacokinetic study in paediatric renal transplant candidates

British journal of clinical pharmacology, 2007-12, Vol.64 (6), p.772-784

2007

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Plasma concentrations of active simvastatin acid are increased by gemfibrozil

Clinical pharmacology and therapeutics, 2000-08, Vol.68 (2), p.122-129

2000

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Intravenous lipid emulsion for levobupivacaine intoxication in acidotic and hypoxaemic pigs

Anaesthesia and intensive care, 2016-03, Vol.44 (2), p.270-277

2016

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The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin

European journal of clinical pharmacology, 1998-03, Vol.54 (1), p.53-58

1998

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Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole

Clinical pharmacology and therapeutics, 1994-05, Vol.55 (5), p.481-485

1994

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Itraconazole, a potent inhibitor of P-glycoprotein, moderately increases plasma concentrations of oral morphine

Acta anaesthesiologica Scandinavica, 2008-11, Vol.52 (10), p.1319-1326

2008

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Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism

The pharmacogenomics journal, 2008-08, Vol.8 (4), p.268-277

2008

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Effect of fluconazole on plasma fluvastatin and pravastatin concentrations

European journal of clinical pharmacology, 2000-06, Vol.56 (3), p.225-229

2000

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Anti-Müllerian hormone and letrozole levels in boys with constitutional delay of growth and puberty treated with letrozole or testosterone

Human reproduction (Oxford), 2020-02, Vol.35 (2), p.257-264

2020

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Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans

Drug metabolism and disposition, 2000-08, Vol.28 (8), p.959

2000

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Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans

Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug-Drug Interactions

Potent mechanism‐based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates

Carboxylesterase 1 Polymorphism Impairs Oseltamivir Bioactivation in Humans

Grapefruit Juice Inhibits the Metabolic Activation of Clopidogrel

Mechanism-Based Inactivation of CYP2C8 by Gemfibrozil Occurs Rapidly in Humans

The Effect of Gemfibrozil on Repaglinide Pharmacokinetics Persists for at Least 12 h After the Dose: Evidence for Mechanism‐based Inhibition of CYP2C8 In Vivo

Gemfibrozil Is a Strong Inactivator of CYP2C8 in Very Small Multiple Doses

Effects of Gemfibrozil and Atorvastatin on the Pharmacokinetics of Repaglinide in Relation to SLCO1B1 Polymorphism

Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide

Gemfibrozil Impairs Imatinib Absorption and Inhibits the CYP2C8-Mediated Formation of Its Main Metabolite

Gemfibrozil Markedly Increases the Plasma Concentrations of Montelukast: A Previously Unrecognized Role for CYP2C8 in the Metabolism of Montelukast

Effects of Daily Ingestion of Cranberry Juice on the Pharmacokinetics of Warfarin, Tizanidine, and Midazolam-Probes of CYP2C9, CYP1A2, and CYP3A4

The effects of intravenous lipid emulsion on hemodynamic recovery and myocardial cell mitochondrial function after bupivacaine toxicity in anesthetized pigs

Gemfibrozil considerably increases the plasma concentrations of rosiglitazone

Developmental pharmacokinetics of ciclosporin – a population pharmacokinetic study in paediatric renal transplant candidates

Plasma concentrations of active simvastatin acid are increased by gemfibrozil

Intravenous lipid emulsion for levobupivacaine intoxication in acidotic and hypoxaemic pigs

The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin

Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole

Itraconazole, a potent inhibitor of P-glycoprotein, moderately increases plasma concentrations of oral morphine

Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism

Effect of fluconazole on plasma fluvastatin and pravastatin concentrations

Anti-Müllerian hormone and letrozole levels in boys with constitutional delay of growth and puberty treated with letrozole or testosterone

Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans

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