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SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis

PLoS neglected tropical diseases, 2011-06, Vol.5 (6), p.e1151

2011

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Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides

Bioorganic & medicinal chemistry letters, 2018-01, Vol.28 (2), p.207-213

2018

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In Memoriam: Michael Levandowsky (1935–2016)

The Journal of eukaryotic microbiology, 2017-07, Vol.64 (4), p.558-559

2017

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Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin

Biochemical journal, 2002-11, Vol.367 (Pt 3), p.665-675

2002

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Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities

Bioorganic & medicinal chemistry, 2015-03, Vol.23 (5), p.996-1010

2015

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Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis

Antimicrobial Agents and Chemotherapy, 2010-10, Vol.54 (10), p.4379-4388

2010

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Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents

Pharmaceuticals (Basel, Switzerland), 2016-04, Vol.9 (2), p.20

2016

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Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis

Parasitology, 2014-01, Vol.141 (1), p.104-118

2014

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Trypanocidal Activity of 8-Methyl-5′-{[(Z)-4-Aminobut-2-enyl]-(Methylamino)}Adenosine (Genz-644131), an Adenosylmethionine Decarboxylase Inhibitor

Antimicrobial Agents and Chemotherapy, 2009-08, Vol.53 (8), p.3269-3272

2009

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Novel S-Adenosylmethionine Decarboxylase Inhibitors for the Treatment of Human African Trypanosomiasis

Antimicrobial Agents and Chemotherapy, 2009-05, Vol.53 (5), p.2052-2058

2009

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Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis

Future medicinal chemistry, 2011-08, Vol.3 (10), p.1259-1278

2011

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Discovery of Novel Benzoxaborole-Based Potent Antitrypanosomal Agents

ACS medicinal chemistry letters, 2010-07, Vol.1 (4), p.165-169

2010

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2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach

PLoS neglected tropical diseases, 2011-02, Vol.5 (2), p.e956

2011

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Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (12), p.3229-3232

2006

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Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (20), p.5884-5886

2009

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Metabolism of an Alkyl Polyamine Analog by a Polyamine Oxidase from the Microsporidian Encephalitozoon cuniculi

Antimicrobial Agents and Chemotherapy, 2009-06, Vol.53 (6), p.2599-2604

2009

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Multiple Triclosan Targets in Trypanosoma brucei

Eukaryotic Cell, 2004-08, Vol.3 (4), p.855-861

2004

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Chemotherapy of Human African Trypanosomiasis

Interdisciplinary Perspectives on Infectious Diseases, 2009-01, Vol.2009 (2009), p.36-40

2009

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Novel Trypanocidal Analogs of 5′-(Methylthio)-Adenosine

Antimicrobial Agents and Chemotherapy, 2008-01, Vol.52 (1), p.211-219

2008

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Novel Synthetic Polyamines Are Effective in the Treatment of Experimental Microsporidiosis, an Opportunistic AIDS-Associated Infection

Antimicrobial Agents and Chemotherapy, 2002-01, Vol.46 (1), p.55-61

2002

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Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug

International journal of antimicrobial agents, 2007-12, Vol.30 (6), p.555-561

2007

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Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents

Bioorganic & medicinal chemistry letters, 2001-01, Vol.11 (2), p.251-254

2001

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Inducible Resistance to Oxidant Stress in the Protozoan Leishmania chagasi

The Journal of biological chemistry, 2000-10, Vol.275 (43), p.33883-33889

2000

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Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues

Microbiology (Society for General Microbiology), 2004-05, Vol.150 (Pt 5), p.1215-1224

2004

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Novel Alkylpolyamine Analogues that Possess Both Antitrypanosomal and Antimicrosporidial Activity

Bioorganic & medicinal chemistry letters, 2001-06, Vol.11 (12), p.1613-1617

2001

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SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis

Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides

In Memoriam: Michael Levandowsky (1935–2016)

Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin

Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities

Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis

Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents

Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis

Trypanocidal Activity of 8-Methyl-5′-{[(Z)-4-Aminobut-2-enyl]-(Methylamino)}Adenosine (Genz-644131), an Adenosylmethionine Decarboxylase Inhibitor

Novel S-Adenosylmethionine Decarboxylase Inhibitors for the Treatment of Human African Trypanosomiasis

Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis

Discovery of Novel Benzoxaborole-Based Potent Antitrypanosomal Agents

2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach

Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity

Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity

Metabolism of an Alkyl Polyamine Analog by a Polyamine Oxidase from the Microsporidian Encephalitozoon cuniculi

Multiple Triclosan Targets in Trypanosoma brucei

Chemotherapy of Human African Trypanosomiasis

Novel Trypanocidal Analogs of 5′-(Methylthio)-Adenosine

Novel Synthetic Polyamines Are Effective in the Treatment of Experimental Microsporidiosis, an Opportunistic AIDS-Associated Infection

Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug

Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents

Inducible Resistance to Oxidant Stress in the Protozoan Leishmania chagasi

Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues

Novel Alkylpolyamine Analogues that Possess Both Antitrypanosomal and Antimicrosporidial Activity

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