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Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis

Cell death and differentiation, 2012-12, Vol.19 (12), p.2040-2048

2012

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DIVERGENT EVOLUTION OF ENZYMATIC FUNCTION: Mechanistically Diverse Superfamilies and Functionally Distinct Suprafamilies

Annual review of biochemistry, 2001-01, Vol.70 (1), p.209-246

2001

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Shotgun : getting more from sequence similarity searches

Bioinformatics, 1999-09, Vol.15 (9), p.729-740

1999

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Reengineering the Glutathione S-Transferase Scaffold: A Rational Design Strategy Pays off

Proceedings of the National Academy of Sciences - PNAS, 2000-09, Vol.97 (19), p.10298-10300

Babbitt, Patricia C.

2000

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Understanding enzyme superfamilies. Chemistry As the fundamental determinant in the evolution of new catalytic activities

The Journal of biological chemistry, 1997-12, Vol.272 (49), p.30591-30594

1997

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A functionally diverse enzyme superfamily that abstracts the α protons of carboxylic acids

Science (American Association for the Advancement of Science), 1995-02, Vol.267 (5201), p.1159-1161

1995

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Ancestry of the 4-chlorobenzoate dehalogenase: analysis of amino acid sequence identities among families of acyl:adenyl ligases, enoyl-CoA hydratases/isomerases, and acyl-CoA thioesterases

Biochemistry (Easton), 1992-06, Vol.31 (24), p.5594-5604

1992

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Mutagenesis of Two Acidic Active Site Residues in Human Muscle Creatine Kinase: Implications for the Catalytic Mechanism

Biochemistry (Easton), 2001-03, Vol.40 (10), p.3056-3061

2001

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Exploration of the Relationship between Tetrachlorohydroquinone Dehalogenase and the Glutathione S-Transferase Superfamily

Biochemistry (Easton), 1996-11, Vol.35 (46), p.14634-14642

1996

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The Enolase Superfamily: A General Strategy for Enzyme-Catalyzed Abstraction of the α-Protons of Carboxylic Acids

Biochemistry (Easton), 1996-12, Vol.35 (51), p.16489-16501

1996

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Novel Enzymic Hydrolytic Dehalogenation of a Chlorinated Aromatic

Science (American Association for the Advancement of Science), 1991-07, Vol.253 (5016), p.182-185

1991

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Mandelate pathway of Pseudomonas putida: sequence relationships involving mandelate racemase, (S)-mandelate dehydrogenase, and benzoylformate decarboxylase and expression of benzoylformate decarboxylase in Escherichia coli

Biochemistry (Easton), 1990-10, Vol.29 (42), p.9856-9862

1990

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Unexpected Divergence of Enzyme Function and Sequence: “N-Acylamino Acid Racemase” Is o-Succinylbenzoate Synthase

Biochemistry (Easton), 1999-04, Vol.38 (14), p.4252-4258

1999

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Functional assignment of the 20 S proteasome from Trypanosoma brucei using mass spectrometry and new bioinformatics approaches

The Journal of biological chemistry, 2001-07, Vol.276 (30), p.28327-28339

2001

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Mechanistically diverse enzyme superfamilies: the importance of chemistry in the evolution of catalysis

Current opinion in chemical biology, 1998, Vol.2 (5), p.607-612

1998

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Sequence Verification of Human Creatine Kinase (43 kDa) Isozymes by High- Resolution Tandem Mass Spectrometry

Proceedings of the National Academy of Sciences - PNAS, 1995-12, Vol.92 (25), p.11451-11455

1995

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Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily

Proceedings of the National Academy of Sciences - PNAS, 2012-03, Vol.109 (11), p.4122-4127

2012

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Analysis of sequence homologies in plant and bacterial pyruvate phosphate dikinase, enzyme I of the bacterial phosphoenolpyruvate : sugar phosphotransferase system and other PEP-utilizing enzymes. Identification of potential catalytic and regulatory motifs

Biochemistry (Easton), 1990-12, Vol.29 (48), p.10757-10765

1990

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3-Carboxy-cis,cis-muconate lactonizing enzyme from Pseudomonas putida is homologous to the class II fumarase family: a new reaction in the evolution of a mechanistic motif

Biochemistry (Easton), 1992-10, Vol.31 (40), p.9768-9776

1992

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Evolution of Enzymatic Activities in the Enolase Superfamily: Characterization of the (D)-Glucarate/Galactarate Catabolic Pathway in Escherichia coli

Biochemistry (Easton), 1998-10, Vol.37 (41), p.14369-14375

1998

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Evidence That pcpA Encodes 2,6-Dichlorohydroquinone Dioxygenase, the Ring Cleavage Enzyme Required for Pentachlorophenol Degradation in Sphingomonas chlorophenolica Strain ATCC 39723

Biochemistry (Easton), 1999-06, Vol.38 (24), p.7659-7669

1999

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Evolution of an Enzyme Active Site: The Structure of a New Crystal Form of Muconate Lactonizing Enzyme Compared with Mandelate Racemase and Enolase

Proceedings of the National Academy of Sciences - PNAS, 1998-09, Vol.95 (18), p.10396-10401

1998

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A novel structural basis for membrane association of a protein: Construction of a chimeric soluble mutant of (S)-mandelate dehydrogenase from Pseudomonas putida

Biochemistry (Easton), 1993-12, Vol.32 (48), p.12959-12967

1993

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Barrels in pieces?

Nature structural & molecular biology, 2001-01, Vol.8 (1), p.5-7

2001

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Removal of a Proteolytic Activity Associated with Aggregates Formed from Expression of Creatine Kinase in Escherichia coli Leads to Improved Recovery of Active Enzyme

Bio/technology (New York, N.Y. 1983), 1990-10, Vol.8 (10), p.945-949

1990

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Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis

DIVERGENT EVOLUTION OF ENZYMATIC FUNCTION: Mechanistically Diverse Superfamilies and Functionally Distinct Suprafamilies

Shotgun : getting more from sequence similarity searches

Reengineering the Glutathione S-Transferase Scaffold: A Rational Design Strategy Pays off

Understanding enzyme superfamilies. Chemistry As the fundamental determinant in the evolution of new catalytic activities

A functionally diverse enzyme superfamily that abstracts the α protons of carboxylic acids

Ancestry of the 4-chlorobenzoate dehalogenase: analysis of amino acid sequence identities among families of acyl:adenyl ligases, enoyl-CoA hydratases/isomerases, and acyl-CoA thioesterases

Mutagenesis of Two Acidic Active Site Residues in Human Muscle Creatine Kinase: Implications for the Catalytic Mechanism

Exploration of the Relationship between Tetrachlorohydroquinone Dehalogenase and the Glutathione S-Transferase Superfamily

The Enolase Superfamily: A General Strategy for Enzyme-Catalyzed Abstraction of the α-Protons of Carboxylic Acids

Novel Enzymic Hydrolytic Dehalogenation of a Chlorinated Aromatic

Mandelate pathway of Pseudomonas putida: sequence relationships involving mandelate racemase, (S)-mandelate dehydrogenase, and benzoylformate decarboxylase and expression of benzoylformate decarboxylase in Escherichia coli

Unexpected Divergence of Enzyme Function and Sequence: “N-Acylamino Acid Racemase” Is o-Succinylbenzoate Synthase

Functional assignment of the 20 S proteasome from Trypanosoma brucei using mass spectrometry and new bioinformatics approaches

Mechanistically diverse enzyme superfamilies: the importance of chemistry in the evolution of catalysis

Sequence Verification of Human Creatine Kinase (43 kDa) Isozymes by High- Resolution Tandem Mass Spectrometry

Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily

Analysis of sequence homologies in plant and bacterial pyruvate phosphate dikinase, enzyme I of the bacterial phosphoenolpyruvate : sugar phosphotransferase system and other PEP-utilizing enzymes. Identification of potential catalytic and regulatory motifs

3-Carboxy-cis,cis-muconate lactonizing enzyme from Pseudomonas putida is homologous to the class II fumarase family: a new reaction in the evolution of a mechanistic motif

Evolution of Enzymatic Activities in the Enolase Superfamily: Characterization of the (D)-Glucarate/Galactarate Catabolic Pathway in Escherichia coli

Evidence That pcpA Encodes 2,6-Dichlorohydroquinone Dioxygenase, the Ring Cleavage Enzyme Required for Pentachlorophenol Degradation in Sphingomonas chlorophenolica Strain ATCC 39723

Evolution of an Enzyme Active Site: The Structure of a New Crystal Form of Muconate Lactonizing Enzyme Compared with Mandelate Racemase and Enolase

A novel structural basis for membrane association of a protein: Construction of a chimeric soluble mutant of (S)-mandelate dehydrogenase from Pseudomonas putida

Barrels in pieces?

Removal of a Proteolytic Activity Associated with Aggregates Formed from Expression of Creatine Kinase in Escherichia coli Leads to Improved Recovery of Active Enzyme

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