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PROTAC targeted protein degraders: the past is prologue

Nature reviews. Drug discovery, 2022-03, Vol.21 (3), p.181-200

2022

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Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease

Molecular cell, 2016-05, Vol.62 (4), p.572-585

2016

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Deubiquitinases as a Signaling Target of Oxidative Stress

Cell reports (Cambridge), 2012-12, Vol.2 (6), p.1475-1484

2012

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SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function

eLife, 2017-05, Vol.6

2017

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The Dynamics and Mechanism of SUMO Chain Deconjugation by SUMO-specific Proteases

The Journal of biological chemistry, 2011-03, Vol.286 (12), p.10238-10247

2011

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Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules

Nature structural & molecular biology, 2024-02, Vol.31 (2), p.311

2024

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Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs

The Journal of biological chemistry, 2007-09, Vol.282 (36), p.26217-26224

2007

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Protection from Isopeptidase-Mediated Deconjugation Regulates Paralog-Selective Sumoylation of RanGAP1

Molecular cell, 2009-03, Vol.33 (5), p.570-580

2009

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The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity

Fly (Austin, Tex.), 2018-04, Vol.12 (2), p.118-126

2018

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DUB-Resistant Ubiquitin to Survey Ubiquitination Switches in Mammalian Cells

Cell reports (Cambridge), 2013-11, Vol.5 (3), p.826-838

2013

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Trojan Horse Strategies Used by Pathogens to Influence the Small Ubiquitin-Like Modifier (SUMO) System of Host Eukaryotic Cells

Journal of innate immunity, 2012-01, Vol.4 (2), p.159-167

2012

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The CULt of Caspase-8 Ubiquitination

Cell, 2009-05, Vol.137 (4), p.604-606

2009

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Mechanistic and Structural Features of PROTAC Ternary Complexes

Methods in molecular biology (Clifton, N.J.), 2021, Vol.2365, p.79

2021

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SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme

Biochemical journal, 2015-06, Vol.468 (2), p.215-226

2015

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A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease

Cell reports (Cambridge), 2021-09, Vol.36 (13), p.109754-109754, Article 109754

2021

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Evaluating Ligands for Ubiquitin Ligases Using Affinity Beads

Methods in molecular biology (Clifton, N.J.), 2021, Vol.2365, p.59

2021

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Protein Ligand Interactions Using Surface Plasmon Resonance

Methods in molecular biology (Clifton, N.J.), 2021, Vol.2365, p.3

O'Connell, Nichole

2021

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Engineered Hybrid Dimers: Tracking the Activation Pathway of Caspase-7

Molecular cell, 2006-08, Vol.23 (4), p.523-533

2006

Volltextzugriff (PDF)

Small Ubiquitin-related Modifier (SUMO)-specific Proteases

The Journal of biological chemistry, 2007-09, Vol.282 (36), p.26217-26224

2007

Volltextzugriff (PDF)

Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease

Molecular cell, 2016-05, Vol.62 (4)

2016

Volltextzugriff (PDF)

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design

Science advances, 2020-10, Vol.6 (42)

2020

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The Auto-Generated Fragment of the Usp1 Deubiquitylase Is a Physiological Substrate of the N-End Rule Pathway

Molecular cell, 2012-12, Vol.48 (6), p.926-933

2012

Volltextzugriff (PDF)

Development of Small Molecule Inhibitors and Probes of Human SUMO Deconjugating Proteases

Chemistry & biology, 2011-06, Vol.18 (6), p.722-732

2011

Volltextzugriff (PDF)

Functional Characterization of a SUMO Deconjugating Protease of Plasmodium falciparum Using Newly Identified Small Molecule Inhibitors

Chemistry & biology, 2011-06, Vol.18 (6), p.711-721

2011

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Structure and Substrate Recognition of the Escherichia coli DNA Adenine Methyltransferase

Journal of molecular biology, 2006-04, Vol.358 (2), p.559-570

2006

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PROTAC targeted protein degraders: the past is prologue

Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease

Deubiquitinases as a Signaling Target of Oxidative Stress

SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function

The Dynamics and Mechanism of SUMO Chain Deconjugation by SUMO-specific Proteases

Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules

Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs

Protection from Isopeptidase-Mediated Deconjugation Regulates Paralog-Selective Sumoylation of RanGAP1

The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity

DUB-Resistant Ubiquitin to Survey Ubiquitination Switches in Mammalian Cells

Trojan Horse Strategies Used by Pathogens to Influence the Small Ubiquitin-Like Modifier (SUMO) System of Host Eukaryotic Cells

The CULt of Caspase-8 Ubiquitination

Mechanistic and Structural Features of PROTAC Ternary Complexes

SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme

A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease

Evaluating Ligands for Ubiquitin Ligases Using Affinity Beads

Protein Ligand Interactions Using Surface Plasmon Resonance

Engineered Hybrid Dimers: Tracking the Activation Pathway of Caspase-7

Small Ubiquitin-related Modifier (SUMO)-specific Proteases

Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design

The Auto-Generated Fragment of the Usp1 Deubiquitylase Is a Physiological Substrate of the N-End Rule Pathway

Development of Small Molecule Inhibitors and Probes of Human SUMO Deconjugating Proteases

Functional Characterization of a SUMO Deconjugating Protease of Plasmodium falciparum Using Newly Identified Small Molecule Inhibitors

Structure and Substrate Recognition of the Escherichia coli DNA Adenine Methyltransferase

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