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Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases

Journal of medicinal chemistry, 2021-11, Vol.64 (21), p.15549-15581

2021

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Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis

ACS medicinal chemistry letters, 2021-09, Vol.12 (9), p.1413-1420

2021

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Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5‑HT2C Receptor Agonists

Journal of medicinal chemistry, 2017-07, Vol.60 (14), p.6166-6190

2017

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Parabrachial Nucleus Lesions Block Taste and Attenuate Flavor Preference and Aversion Conditioning in Rats

Behavioral neuroscience, 2001-08, Vol.115 (4), p.920-933

2001

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Characterization of CD28null T cells in idiopathic pulmonary fibrosis

Mucosal immunology, 2019, Vol.12 (1), p.212-222

2019

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Naltrexone fails to block the acquisition or expression of a flavor preference conditioned by intragastric carbohydrate infusions

Pharmacology, biochemistry and behavior, 2000-11, Vol.67 (3), p.545-557

2000

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Flavor preferences conditioned by intragastric sugar infusions in rats: maltose is more reinforcing than sucrose

Physiology & behavior, 1998-06, Vol.64 (4), p.535-541

1998

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Acylation of Acylglycerols by Acyl Coenzyme A:Diacylglycerol Acyltransferase 1 (DGAT1): FUNCTIONAL IMPORTANCE OF DGAT1 IN THE INTESTINAL FAT ABSORPTION

The Journal of biological chemistry, 2008-10, Vol.283 (44), p.29802-29811

2008

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Roles for central leptin receptors in the control of meal size

Appetite, 2013-12, Vol.71, p.466-469

2013

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Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT 2C Receptor Agonists

Journal of medicinal chemistry, 2017-07, Vol.60 (14), p.6166-6190

2017

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Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies

Bioorganic & medicinal chemistry letters, 2015-10, Vol.25 (20), p.4412-4418

2015

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Differential regulation of plant secondary compounds by herbivorous rodents

Functional ecology, 2011-12, Vol.25 (6), p.1232-1240

2011

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Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup

Bioorganic & medicinal chemistry letters, 2015-07, Vol.25 (14), p.2793-2799

2015

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Liquid-liquid extraction coupled with LC/MS/MS for monitoring of malonyl-CoA in rat brain tissue

Analytical and bioanalytical chemistry, 2010-08, Vol.397 (7), p.3137-3142

2010

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An Old Dog Learns a New Trick: Regulation of Peripheral Glucose Homeostasis by the Serotonin (5-HT)2C Receptor

Molecular interventions, 2008-04, Vol.8 (2), p.73-77

2008

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Conditioned Flavor Avoidance, Preference, and Indifference Produced by Intragastric Infusions of Galactose, Glucose, and Fructose in Rats

Physiology & behavior, 1999-08, Vol.67 (2), p.227-234

1999

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Central melanocortin receptor agonist reduces spontaneous and scheduled meal size but does not augment duodenal preload-induced feeding inhibition

Physiology & behavior, 2002-11, Vol.77 (2), p.411-416

2002

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Transcriptome analysis reveals key genes modulated by ALK5 inhibition in a bleomycin model of systemic sclerosis

Rheumatology (Oxford, England), 2022-04, Vol.61 (4), p.1717-1727

2022

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D1 but not D2 dopamine receptor antagonism blocks the acquisition of a flavor preference conditioned by intragastric carbohydrate infusions

Pharmacology, biochemistry and behavior, 2001-04, Vol.68 (4), p.709-720

2001

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Genetic and biobehavioral analysis of the controls of meal size in mice

Appetite, 2004-02, Vol.42 (1), p.107-109

Azzara, Anthony V

2004

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Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases

Identification of a Nonbasic Melanin Hormone Receptor 1 Antagonist as an Antiobesity Clinical Candidate

MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity

Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders

Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis

Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5‑HT2C Receptor Agonists

Parabrachial Nucleus Lesions Block Taste and Attenuate Flavor Preference and Aversion Conditioning in Rats

Characterization of CD28null T cells in idiopathic pulmonary fibrosis

Naltrexone fails to block the acquisition or expression of a flavor preference conditioned by intragastric carbohydrate infusions

Flavor preferences conditioned by intragastric sugar infusions in rats: maltose is more reinforcing than sucrose

Synthesis and Antiobesity Properties of 6‑(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2‑d]pyrimidin-4(3H)‑one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor

Acylation of Acylglycerols by Acyl Coenzyme A:Diacylglycerol Acyltransferase 1 (DGAT1): FUNCTIONAL IMPORTANCE OF DGAT1 IN THE INTESTINAL FAT ABSORPTION

Roles for central leptin receptors in the control of meal size

Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT 2C Receptor Agonists

Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies

Differential regulation of plant secondary compounds by herbivorous rodents

Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup

Reductions in log P Improved Protein Binding and Clearance Predictions Enabling the Prospective Design of Cannabinoid Receptor (CB1) Antagonists with Desired Pharmacokinetic Properties

Liquid-liquid extraction coupled with LC/MS/MS for monitoring of malonyl-CoA in rat brain tissue

An Old Dog Learns a New Trick: Regulation of Peripheral Glucose Homeostasis by the Serotonin (5-HT)2C Receptor

Conditioned Flavor Avoidance, Preference, and Indifference Produced by Intragastric Infusions of Galactose, Glucose, and Fructose in Rats

Central melanocortin receptor agonist reduces spontaneous and scheduled meal size but does not augment duodenal preload-induced feeding inhibition

Transcriptome analysis reveals key genes modulated by ALK5 inhibition in a bleomycin model of systemic sclerosis

D1 but not D2 dopamine receptor antagonism blocks the acquisition of a flavor preference conditioned by intragastric carbohydrate infusions

Genetic and biobehavioral analysis of the controls of meal size in mice

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