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Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions

Journal of pharmacokinetics and pharmacodynamics, 2021-06, Vol.48 (3), p.321-338

2021

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Pharmacokinetic and Pharmacodynamic Modeling of siRNA Therapeutics – a Minireview

Pharmaceutical research, 2022-08, Vol.39 (8), p.1749-1759

2022

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Minimal Physiologically-Based Pharmacokinetic (mPBPK) Metamodeling of Target Engagement in Skin Informs Anti-IL17A Drug Development in Psoriasis

Frontiers in pharmacology, 2022-04, Vol.13, p.862291-862291

2022

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Mechanistic pharmacokinetics and pharmacodynamics of GalNAc-siRNA: Translational model involving competitive receptor-mediated disposition and RISC-dependent gene silencing applied to givosiran

Journal of pharmaceutical sciences, 2024-01, Vol.113 (1), p.176-190

2024

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ATLAS mPBPK: A MATLAB‐Based Tool for Modeling and Simulation of Minimal Physiologically‐Based Pharmacokinetic Models

CPT: pharmacometrics and systems pharmacology, 2019-08, Vol.8 (8), p.557-566

2019

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CPT: Pharmacometrics & Systems Pharmacology – Inception, Maturation, and Future Vision

CPT: pharmacometrics and systems pharmacology, 2021-07, Vol.10 (7), p.649-657

2021

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Transitioning from Basic toward Systems Pharmacodynamic Models: Lessons from Corticosteroids

Pharmacological reviews, 2020-04, Vol.72 (2), p.414-438

2020

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Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor‐T Cells in Humans

Clinical pharmacology and therapeutics, 2021-03, Vol.109 (3), p.716-727

2021

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Minimal Physiologically Based Pharmacokinetic-Pharmacodynamic (mPBPK-PD) Model of N -Acetylgalactosamine-Conjugated Small Interfering RNA Disposition and Gene Silencing in Preclinical Species and Humans

The Journal of pharmacology and experimental therapeutics, 2021-11, Vol.379 (2), p.134-146

2021

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Pharmacodynamic models of indirect effects and irreversible inactivation with turnover: applicability to mechanism-based modeling of gene silencing and targeted protein degradation

Journal of pharmaceutical sciences, 2024-01, Vol.113 (1), p.191-201

2024

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Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part II: Sex Differences in Methylprednisolone Pharmacokinetics and Corticosterone Suppression

The Journal of pharmacology and experimental therapeutics, 2019-08, Vol.370 (2), p.327-336

2019

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Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part I: Determination and Prediction of Dexamethasone and Methylprednisolone Tissue Binding in the Rat

The Journal of pharmacology and experimental therapeutics, 2019-08, Vol.370 (2), p.318-326

2019

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Seeking Nonspecific Binding: Assessing the Reliability of Tissue Dilutions for Calculating Fraction Unbound

Drug metabolism and disposition, 2020-10, Vol.48 (10), p.894-902

2020

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Phase 1 Trials of PNPLA3 siRNA in I148M Homozygous Patients with MAFLD

The New England journal of medicine, 2024-08, Vol.391 (5), p.475-476

2024

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Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part III: Estrous Cycle and Estrogen Receptor-Dependent Antagonism of Glucocorticoid-Induced Leucine Zipper (GILZ) Enhancement by Corticosteroids

The Journal of pharmacology and experimental therapeutics, 2019-08, Vol.370 (2), p.337-349

2019

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Translational PK/PD and model-informed development of JNJ-67842125, a F ab reversal agent for JNJ-64179375, a long-acting thrombin inhibitor

British journal of pharmacology, 2021-10, Vol.178 (19), p.3943-3958

2021

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Translational PK/PD and model‐informed development of JNJ‐67842125, a Fab reversal agent for JNJ‐64179375, a long‐acting thrombin inhibitor

British journal of pharmacology, 2021-10, Vol.178 (19), p.3943-3958

2021

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Mechanistic Multi-Tissue Modeling of Glucocorticoid-Induced Leucine Zipper Regulation: Integrating Circadian Gene Expression with Receptor-Mediated Corticosteroid Pharmacodynamics

The Journal of pharmacology and experimental therapeutics, 2017-10, Vol.363 (1), p.45-57

2017

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Modeling Corticosteroid Pharmacogenomics and Proteomics in Rat Liver

The Journal of pharmacology and experimental therapeutics, 2018-10, Vol.367 (1), p.168-183

2018

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Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism

Journal of proteomics, 2017-05, Vol.160, p.84-105

2017

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Indirect pharmacodynamic models for responses with circadian removal

Journal of pharmacokinetics and pharmacodynamics, 2019-02, Vol.46 (1), p.89-101

2019

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Receptor/gene/protein-mediated signaling connects methylprednisolone exposure to metabolic and immune-related pharmacodynamic actions in liver

Journal of pharmacokinetics and pharmacodynamics, 2018-08, Vol.45 (4), p.557-575

2018

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Quantitative tissue‐specific dynamics of in vivo GILZ mRNA expression and regulation by endogenous and exogenous glucocorticoids

Physiological reports, 2015-06, Vol.3 (6), p.e12382-n/a

2015

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CPT: Pharmacometrics & Systems Pharmacology - Inception, Maturation, and Future Vision

CPT: pharmacometrics and systems pharmacology, 2021, Vol.10 (7), p.649

2021

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Pharmacokinetics and Receptor-Mediated Pharmacodynamics of Methylprednisolone

Ayyar, Vivaswath S

2019

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Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions

Pharmacokinetic and Pharmacodynamic Modeling of siRNA Therapeutics – a Minireview

Minimal Physiologically-Based Pharmacokinetic (mPBPK) Metamodeling of Target Engagement in Skin Informs Anti-IL17A Drug Development in Psoriasis

Mechanistic pharmacokinetics and pharmacodynamics of GalNAc-siRNA: Translational model involving competitive receptor-mediated disposition and RISC-dependent gene silencing applied to givosiran

ATLAS mPBPK: A MATLAB‐Based Tool for Modeling and Simulation of Minimal Physiologically‐Based Pharmacokinetic Models

CPT: Pharmacometrics & Systems Pharmacology – Inception, Maturation, and Future Vision

Transitioning from Basic toward Systems Pharmacodynamic Models: Lessons from Corticosteroids

Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor‐T Cells in Humans

Minimal Physiologically Based Pharmacokinetic-Pharmacodynamic (mPBPK-PD) Model of N -Acetylgalactosamine-Conjugated Small Interfering RNA Disposition and Gene Silencing in Preclinical Species and Humans

Pharmacodynamic models of indirect effects and irreversible inactivation with turnover: applicability to mechanism-based modeling of gene silencing and targeted protein degradation

Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part II: Sex Differences in Methylprednisolone Pharmacokinetics and Corticosterone Suppression

Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part I: Determination and Prediction of Dexamethasone and Methylprednisolone Tissue Binding in the Rat

Seeking Nonspecific Binding: Assessing the Reliability of Tissue Dilutions for Calculating Fraction Unbound

Phase 1 Trials of PNPLA3 siRNA in I148M Homozygous Patients with MAFLD

Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part III: Estrous Cycle and Estrogen Receptor-Dependent Antagonism of Glucocorticoid-Induced Leucine Zipper (GILZ) Enhancement by Corticosteroids

Translational PK/PD and model-informed development of JNJ-67842125, a F ab reversal agent for JNJ-64179375, a long-acting thrombin inhibitor

Translational PK/PD and model‐informed development of JNJ‐67842125, a Fab reversal agent for JNJ‐64179375, a long‐acting thrombin inhibitor

Mechanistic Multi-Tissue Modeling of Glucocorticoid-Induced Leucine Zipper Regulation: Integrating Circadian Gene Expression with Receptor-Mediated Corticosteroid Pharmacodynamics

Modeling Corticosteroid Pharmacogenomics and Proteomics in Rat Liver

Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism

Indirect pharmacodynamic models for responses with circadian removal

Receptor/gene/protein-mediated signaling connects methylprednisolone exposure to metabolic and immune-related pharmacodynamic actions in liver

Quantitative tissue‐specific dynamics of in vivo GILZ mRNA expression and regulation by endogenous and exogenous glucocorticoids

CPT: Pharmacometrics & Systems Pharmacology - Inception, Maturation, and Future Vision

Pharmacokinetics and Receptor-Mediated Pharmacodynamics of Methylprednisolone

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