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Prion-like Spreading in Tauopathies

Biological psychiatry (1969), 2018-02, Vol.83 (4), p.337-346

2018

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Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

PloS one, 2020-01, Vol.15 (1), p.e0227655

2020

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Prion protein - mediator of toxicity in multiple proteinopathies

Nature reviews. Neurology, 2020-04, Vol.16 (4), p.187-188

2020

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Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (29), p.10732-10737

2014

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Phenotypic diversity in ALS and the role of poly-conformational protein misfolding

Acta neuropathologica, 2021-07, Vol.142 (1), p.41-55

2021

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Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy

Proceedings of the National Academy of Sciences - PNAS, 2022-02, Vol.119 (6), p.1

2022

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Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways

Acta neuropathologica, 2016-01, Vol.131 (1), p.103-114

2016

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Novel SOD1 monoclonal antibodies against the electrostatic loop preferentially detect misfolded SOD1 aggregates

Neuroscience letters, 2021-01, Vol.742, p.135553-135553, Article 135553

2021

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The Strain-Encoded Relationship between PrPSc Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease

PLoS pathogens, 2011-03, Vol.7 (3), p.e1001317

2011

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Expanding spectrum of prion diseases

Emerging topics in life sciences, 2020-09, Vol.4 (2), p.155-167

2020

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Experimental transmissibility of mutant SOD1 motor neuron disease

Acta neuropathologica, 2014-12, Vol.128 (6), p.791-803

2014

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Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts

Journal of virology, 2018-09, Vol.92 (18)

2018

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Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models

PloS one, 2018-11, Vol.13 (11), p.e0206751-e0206751

2018

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Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice

Viruses, 2023-08, Vol.15 (9), p.1819

2023

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Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS

Acta neuropathologica, 2016-12, Vol.132 (6), p.827-840

2016

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Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils

Journal of virology, 2017-01, Vol.91 (2)

2017

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Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions

Proceedings of the National Academy of Sciences - PNAS, 2023-03, Vol.120 (13), p.e2220984120-e2220984120

2023

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The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease

PLoS pathogens, 2011-03, Vol.7 (3), p.e1001317-e1001317

2011

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Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence

Acta neuropathologica communications, 2021-05, Vol.9 (1), p.92-92, Article 92

2021

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Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding

The Journal of biological chemistry, 2017-11, Vol.292 (47), p.19366-19380

2017

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Prion-like mechanisms in amyotrophic lateral sclerosis

Handbook of Clinical Neurology, 2018, Vol.153, p.337-354

2018

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Coinfecting Prion Strains Compete for a Limiting Cellular Resource

Journal of Virology, 2010-06, Vol.84 (11), p.5706-5714

2010

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Widespread and Efficient Transduction of Spinal Cord and Brain Following Neonatal AAV Injection and Potential Disease Modifying Effect in ALS Mice

Molecular therapy, 2015-01, Vol.23 (1), p.53-62

2015

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Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models

Journal of neurochemistry, 2017-01, Vol.140 (1), p.140-150

2017

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Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases

Acta neuropathologica communications, 2014-05, Vol.2 (1), p.55-55, Article 55

2014

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Prion-like Spreading in Tauopathies

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

Prion protein - mediator of toxicity in multiple proteinopathies

Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice

Phenotypic diversity in ALS and the role of poly-conformational protein misfolding

Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy

Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways

Novel SOD1 monoclonal antibodies against the electrostatic loop preferentially detect misfolded SOD1 aggregates

The Strain-Encoded Relationship between PrPSc Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease

Expanding spectrum of prion diseases

Experimental transmissibility of mutant SOD1 motor neuron disease

Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts

Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models

Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice

Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS

Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils

Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions

The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease

Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence

Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding

Prion-like mechanisms in amyotrophic lateral sclerosis

Coinfecting Prion Strains Compete for a Limiting Cellular Resource

Widespread and Efficient Transduction of Spinal Cord and Brain Following Neonatal AAV Injection and Potential Disease Modifying Effect in ALS Mice

Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models

Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases

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