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Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

mAbs, 2018-02, Vol.10 (2), p.244-255

2018

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Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies

mAbs, 2016-08, Vol.8 (6), p.1064-1078

2016

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A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data

CPT: pharmacometrics and systems pharmacology, 2019-10, Vol.8 (10), p.738-747

2019

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Pharmacological activation of myosin II paralogs to correct cell mechanics defects

Proceedings of the National Academy of Sciences - PNAS, 2015-02, Vol.112 (5), p.1428-1433

2015

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Human Biotransformation of the Nonnucleoside Reverse Transcriptase Inhibitor Rilpivirine and a Cross-Species Metabolism Comparison

Antimicrobial Agents and Chemotherapy, 2013-10, Vol.57 (10), p.5067-5079

2013

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A highly sensitive ultra performance liquid chromatography–tandem mass spectrometric (UPLC–MS/MS) technique for quantitation of protein free and bound efavirenz (EFV) in human seminal and blood plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010-12, Vol.878 (31), p.3217-3224

2010

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Valproic acid is a novel activator of AMP-activated protein kinase and decreases liver mass, hepatic fat accumulation, and serum glucose in obese mice

Molecular pharmacology, 2014-01, Vol.85 (1), p.1-10

2014

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Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach

mAbs, 2018-07, Vol.10 (5), p.751-764

2018

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Dendritic spine injury induced by the 8-hydroxy metabolite of efavirenz

The Journal of pharmacology and experimental therapeutics, 2012-12, Vol.343 (3), p.696

2012

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Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics

mAbs, 2018-01, Vol.10 (1), p.81-94

2018

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Mechanistic incorporation of FcRn binding in plasma and endosomes in a whole body PBPK model for large molecules

Journal of pharmacokinetics and pharmacodynamics, 2023-06, Vol.50 (3), p.229-241

2023

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A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1

ACS chemical biology, 2014-06, Vol.9 (6), p.1284-1293

2014

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Neuroprotective maraviroc monotherapy in simian immunodeficiency virus-infected macaques: reduced replicating and latent SIV in the brain

AIDS (London), 2013-11, Vol.27 (18), p.F21-F28

2013

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Compartmentalization and antiviral effect of efavirenz metabolites in blood plasma, seminal plasma, and cerebrospinal fluid

Drug metabolism and disposition, 2013-02, Vol.41 (2), p.422

2013

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Increasing extracellular protein concentration reduces intracellular antiretroviral drug concentration and antiviral effect

AIDS research and human retroviruses, 2013-11, Vol.29 (11), p.1434

2013

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Compartmental distribution and antiviral effect of efavirenz metabolites

The FASEB journal, 2013-04, Vol.27 (S1)

2013

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The effect of protein binding on antiretroviral drug distribution and antiviral effect among diverse anatomic compartments

Avery, Lindsay B

2012

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Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach

mAbs, 2018, Vol.10 (5), p.751-764

2018

Volltextzugriff (PDF)

Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics

mAbs, 2018, Vol.10 (1), p.81-94

2018

Volltextzugriff (PDF)

Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

mAbs, 2018, Vol.10 (2), p.244-255

2018

Volltextzugriff (PDF)

Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies

mAbs, 2016, Vol.8 (6), p.1064-1078

2016

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The Role of Community Cultural Wealth and Influence of Family on First-Generation Graduate Students

Journal of first-generation student success, 2024-01, Vol.4 (1), p.44-62

2024

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Adjuvant docetaxel, doxorubicin, and cyclophosphamide in node-positive breast cancer: 10-year follow-up of the phase 3 randomised BCIRG 001 trial

The lancet oncology, 2013, Vol.14 (1), p.72-80

2013

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Pediatric low-grade gliomas: implications of the biologic era

Neuro-oncology (Charlottesville, Va.), 2017-06, Vol.19 (6), p.750-761

2017

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Evidence-Based Guidelines for Prevention of Perioperative Hypothermia

Journal of the American College of Surgeons, 2009-10, Vol.209 (4), p.492-503.e1

2009

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Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies

A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data

Pharmacological activation of myosin II paralogs to correct cell mechanics defects

Human Biotransformation of the Nonnucleoside Reverse Transcriptase Inhibitor Rilpivirine and a Cross-Species Metabolism Comparison

A highly sensitive ultra performance liquid chromatography–tandem mass spectrometric (UPLC–MS/MS) technique for quantitation of protein free and bound efavirenz (EFV) in human seminal and blood plasma

Valproic acid is a novel activator of AMP-activated protein kinase and decreases liver mass, hepatic fat accumulation, and serum glucose in obese mice

Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach

Dendritic spine injury induced by the 8-hydroxy metabolite of efavirenz

Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics

Mechanistic incorporation of FcRn binding in plasma and endosomes in a whole body PBPK model for large molecules

A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1

Neuroprotective maraviroc monotherapy in simian immunodeficiency virus-infected macaques: reduced replicating and latent SIV in the brain

Compartmentalization and antiviral effect of efavirenz metabolites in blood plasma, seminal plasma, and cerebrospinal fluid

Increasing extracellular protein concentration reduces intracellular antiretroviral drug concentration and antiviral effect

Compartmental distribution and antiviral effect of efavirenz metabolites

The effect of protein binding on antiretroviral drug distribution and antiviral effect among diverse anatomic compartments

Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach

Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics

Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies

The Role of Community Cultural Wealth and Influence of Family on First-Generation Graduate Students

Adjuvant docetaxel, doxorubicin, and cyclophosphamide in node-positive breast cancer: 10-year follow-up of the phase 3 randomised BCIRG 001 trial

Pediatric low-grade gliomas: implications of the biologic era

Evidence-Based Guidelines for Prevention of Perioperative Hypothermia

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