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Absorption and Drug Development: Solubility, Permeability, and Charge State

Avdeef, Alex

2nd Edition, 2012

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Physicochemical profiling (solubility, permeability and charge state)

Current topics in medicinal chemistry, 2001-09, Vol.1 (4), p.277

Avdeef, A

2001

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Physicochemical profiling in drug research: a brief survey of the state-of-the-art of experimental techniques

Cellular and molecular life sciences : CMLS, 2002-10, Vol.59 (10), p.1681-1689

2002

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Lamivudine permeability study: A comparison between PAMPA, ex vivo and in situ Single-Pass Intestinal Perfusion (SPIP) in rat jejunum

European journal of pharmaceutical sciences, 2013-03, Vol.48 (4-5), p.781-789

2013

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In vitro trans-monolayer permeability calculations: often forgotten assumptions

Drug Discovery Today, 2003-11, Vol.8 (21), p.997-1003

2003

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pH-metric logP 10. Determination of liposomal membrane-water partition coefficients of ionizable drugs

Pharmaceutical research, 1998-02, Vol.15 (2), p.209-215

1998

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pH-metric solubility.: 3. Dissolution titration template method for solubility determination

European journal of pharmaceutical sciences, 2001-12, Vol.14 (4), p.281-291

2001

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PAMPA—critical factors for better predictions of absorption

Journal of pharmaceutical sciences, 2007-11, Vol.96 (11), p.2893-2909

2007

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PAMPA : A drug absorption in vitro model 13. chemical selectivity due to membrane hydrogen bonding: In combo comparisons of HDM-, DOPC-, and DS-PAMPA models

European journal of pharmaceutical sciences, 2006-05, Vol.28 (1-2), p.43-50

2006

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Classification Analysis of P-Glycoprotein Substrate Specificity

Journal of drug targeting, 2003-08, Vol.11 (7), p.391-406

2003

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PAMPA—a drug absorption in vitro model: 11. Matching the in vivo unstirred water layer thickness by individual-well stirring in microtitre plates

European journal of pharmaceutical sciences, 2004-08, Vol.22 (5), p.365-374

2004

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Absorption Classification of Oral Drugs Based on Molecular Surface Properties

Journal of medicinal chemistry, 2003-02, Vol.46 (4), p.558-570

2003

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ph-metric solubility. 2 : Correlation between the acid-base titration and the saturation shake-flask solubility-pH methods

Pharmaceutical research, 2000, Vol.17 (1), p.85-89

2000

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Absorption-excipient-pH classification gradient maps: Sparingly soluble drugs and the pH partition hypothesis

European journal of pharmaceutical sciences, 2008, Vol.33 (1), p.29-41

2008

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PAMPA—a drug absorption in vitro model: 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones

European journal of pharmaceutical sciences, 2004-03, Vol.21 (4), p.429-441

2004

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PAMPA—a drug absorption in vitro model: 8. Apparent filter porosity and the unstirred water layer

European journal of pharmaceutical sciences, 2004-05, Vol.22 (1), p.33-41

2004

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In vitro Permeability of poorly aqueous soluble compounds using different solubilizers in the PAMPA assay with liquid chromatography/ mass spectrometry detection

Pharmaceutical research, 2003-11, Vol.20 (11), p.1820-1826

2003

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Drug absorption in vitro model: filter-immobilized artificial membranes: 2. Studies of the permeability properties of lactones in Piper methysticum Forst

European journal of pharmaceutical sciences, 2001-12, Vol.14 (4), p.271-280

2001

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Classification Structure-Activity Relations (C-SAR) in Prediction of Human Intestinal Absorption

Journal of pharmaceutical sciences, 2003-03, Vol.92 (3), p.621-633

2003

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Acid-Base Cosolvent Method for Determining Aqueous Permeability of Amiodarone, Itraconazole, Tamoxifen, Terfenadine and Other Very Insoluble Molecules

Chemical and Pharmaceutical Bulletin, 2004, Vol.52(5), pp.561-565

2004

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Ionization, lipophilicity, and molecular modeling to investigate permeability and other biological properties of amlodipine

Bioorganic & medicinal chemistry, 2004-12, Vol.12 (23), p.6107-6118

2004

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PH-metric log P 11. p K a determination of water-insoluble drugs in organic solvent–water mixtures

Journal of pharmaceutical and biomedical analysis, 1999-08, Vol.20 (4), p.631-641

1999

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Membrane-water partitioning, membrane permeability, and baseline toxicity of the parasiticides invermectin, albendazole, and morantel

Environmental toxicology and chemistry, 2008, Vol.27 (4), p.909-918

2008

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Interlaboratory study of log {ce:inline-formula}P{/ce:inline-formula} determination by shake-flask and potentiometric methods

Journal of pharmaceutical and biomedical analysis, 1996-08, Vol.14 (11), p.1405-1413

1996

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PAMPA—a drug absorption in vitro model111. Matching the in vivo unstirred water layer thickness by individual-well stirring in microtitre plates

European journal of pharmaceutical sciences, 2004-08, Vol.22 (5), p.365-374

2004

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Absorption and Drug Development: Solubility, Permeability, and Charge State

Physicochemical profiling (solubility, permeability and charge state)

Physicochemical profiling in drug research: a brief survey of the state-of-the-art of experimental techniques

Lamivudine permeability study: A comparison between PAMPA, ex vivo and in situ Single-Pass Intestinal Perfusion (SPIP) in rat jejunum

In vitro trans-monolayer permeability calculations: often forgotten assumptions

pH-metric logP 10. Determination of liposomal membrane-water partition coefficients of ionizable drugs

pH-metric solubility.: 3. Dissolution titration template method for solubility determination

PAMPA—critical factors for better predictions of absorption

PAMPA : A drug absorption in vitro model 13. chemical selectivity due to membrane hydrogen bonding: In combo comparisons of HDM-, DOPC-, and DS-PAMPA models

Classification Analysis of P-Glycoprotein Substrate Specificity

PAMPA—a drug absorption in vitro model: 11. Matching the in vivo unstirred water layer thickness by individual-well stirring in microtitre plates

Absorption Classification of Oral Drugs Based on Molecular Surface Properties

ph-metric solubility. 2 : Correlation between the acid-base titration and the saturation shake-flask solubility-pH methods

Absorption-excipient-pH classification gradient maps: Sparingly soluble drugs and the pH partition hypothesis

PAMPA—a drug absorption in vitro model: 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones

PAMPA—a drug absorption in vitro model: 8. Apparent filter porosity and the unstirred water layer

In vitro Permeability of poorly aqueous soluble compounds using different solubilizers in the PAMPA assay with liquid chromatography/ mass spectrometry detection

Drug absorption in vitro model: filter-immobilized artificial membranes: 2. Studies of the permeability properties of lactones in Piper methysticum Forst

Classification Structure-Activity Relations (C-SAR) in Prediction of Human Intestinal Absorption

Acid-Base Cosolvent Method for Determining Aqueous Permeability of Amiodarone, Itraconazole, Tamoxifen, Terfenadine and Other Very Insoluble Molecules

Ionization, lipophilicity, and molecular modeling to investigate permeability and other biological properties of amlodipine

PH-metric log P 11. p K a determination of water-insoluble drugs in organic solvent–water mixtures

Membrane-water partitioning, membrane permeability, and baseline toxicity of the parasiticides invermectin, albendazole, and morantel

Interlaboratory study of log {ce:inline-formula}P{/ce:inline-formula} determination by shake-flask and potentiometric methods

PAMPA—a drug absorption in vitro model111. Matching the in vivo unstirred water layer thickness by individual-well stirring in microtitre plates

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