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Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (16), p.2410-2414

2019

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Comparative Analysis of the Antibacterial Activity of a Novel Peptide Deformylase Inhibitor, GSK1322322

Antimicrobial Agents and Chemotherapy, 2013-05, Vol.57 (5), p.2333-2342

2013

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Potent Sub-MIC Effect of GSK1322322 and Other Peptide Deformylase Inhibitors on In Vitro Growth of Staphylococcus aureus

Antimicrobial Agents and Chemotherapy, 2014-01, Vol.58 (1), p.290-296

2014

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Staphylococcus aureus Formyl-Methionyl Transferase Mutants Demonstrate Reduced Virulence Factor Production and Pathogenicity

Antimicrobial Agents and Chemotherapy, 2013-07, Vol.57 (7), p.2929-2936

2013

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Understanding the Origins of Time-Dependent Inhibition by Polypeptide Deformylase Inhibitors

Biochemistry (Easton), 2011-08, Vol.50 (31), p.6642-6654

2011

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Mechanism of Time-Dependent Inhibition of Polypeptide Deformylase by Actinonin

Biochemistry (Easton), 2005-01, Vol.44 (1), p.253-260

2005

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Phylogenomic and Biochemical Characterization of Three Legionella pneumophila Polypeptide Deformylases

Journal of Bacteriology, 2006-07, Vol.188 (14), p.5249-5257

2006

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Pharmacokinetics/Pharmacodynamics of Peptide Deformylase Inhibitor GSK1322322 against Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in Rodent Models of Infection

Antimicrobial agents and chemotherapy, 2016-01, Vol.60 (1), p.180-189

2016

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A Biomimetic Approach to the Discorhabdin Alkaloids: Total Syntheses of Discorhabdins C and E and Dethiadiscorhabdin D

Journal of organic chemistry, 1999-01, Vol.64 (1), p.16-22

1999

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In vitro and intracellular activities of peptide deformylase inhibitor GSK1322322 against Legionella pneumophila isolates

Antimicrobial agents and chemotherapy, 2015-01, Vol.59 (1), p.707-710

2015

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Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae

Antimicrobial agents and chemotherapy, 2015-08, Vol.59 (8), p.4644-4652

2015

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Microbiome changes in healthy volunteers treated with GSK1322322, a novel antibiotic targeting bacterial peptide deformylase

Antimicrobial agents and chemotherapy, 2015-02, Vol.59 (2), p.1182-1192

2015

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Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors

Bioorganic & medicinal chemistry letters, 2011-02, Vol.21 (3), p.1060-1063

2011

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Peptide Deformylase Inhibitors

Progress in Medicinal Chemistry, 2006, Vol.44, p.109-143

2006

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Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species

Protein science, 2003-02, Vol.12 (2), p.349-360

2003

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3 Peptide Deformylase Inhibitors

Progress in Medicinal Chemistry, 2006, Vol.44, p.109-143

2006

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ChemInform Abstract: Design, Synthesis and Antibacterial Activity of 3-Methylenepyrrolidine Formyl Hydroxyamino Derivatives as Novel Peptide Deformylase Inhibitors

ChemInform, 2011-07, Vol.42 (30), p.no-no

2011

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ChemInform Abstract: A Biomimetic Approach to the Discorhabdin Alkaloids: Total Syntheses of Discorhabdins C and E and Dethiadiscorhabdin D

ChemInform, 1999-06, Vol.30 (25), p.no-no

1999

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Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections

Comparative Analysis of the Antibacterial Activity of a Novel Peptide Deformylase Inhibitor, GSK1322322

Potent Sub-MIC Effect of GSK1322322 and Other Peptide Deformylase Inhibitors on In Vitro Growth of Staphylococcus aureus

Staphylococcus aureus Formyl-Methionyl Transferase Mutants Demonstrate Reduced Virulence Factor Production and Pathogenicity

Understanding the Origins of Time-Dependent Inhibition by Polypeptide Deformylase Inhibitors

Mechanism of Time-Dependent Inhibition of Polypeptide Deformylase by Actinonin

Phylogenomic and Biochemical Characterization of Three Legionella pneumophila Polypeptide Deformylases

Pharmacokinetics/Pharmacodynamics of Peptide Deformylase Inhibitor GSK1322322 against Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in Rodent Models of Infection

A Biomimetic Approach to the Discorhabdin Alkaloids: Total Syntheses of Discorhabdins C and E and Dethiadiscorhabdin D

In vitro and intracellular activities of peptide deformylase inhibitor GSK1322322 against Legionella pneumophila isolates

Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae

Microbiome changes in healthy volunteers treated with GSK1322322, a novel antibiotic targeting bacterial peptide deformylase

Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors

Peptide Deformylase Inhibitors

Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species

3 Peptide Deformylase Inhibitors

ChemInform Abstract: Design, Synthesis and Antibacterial Activity of 3-Methylenepyrrolidine Formyl Hydroxyamino Derivatives as Novel Peptide Deformylase Inhibitors

ChemInform Abstract: A Biomimetic Approach to the Discorhabdin Alkaloids: Total Syntheses of Discorhabdins C and E and Dethiadiscorhabdin D

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