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A PHASE 1 STUDY EVALUATING PRT2527, A POTENT AND HIGHLY SELECTIVE CDK9 INHIBITOR, IN PATIENTS WITH SELECT RELAPSED/REFRACTORY B‐CELL MALIGNANCIES

Hematological oncology, 2023-06, Vol.41 (S2), p.829-830

2023

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PHASE 1 STUDY OF PRT1419 (MCL1 INHIBITOR) AS MONOTHERAPY OR IN COMBINATION WITH AZACITIDINE OR VENETOCLAX IN PATIENTS WITH RELAPSED/REFRACTORY MYELOID OR B‐CELL MALIGNANCIES

Hematological oncology, 2023-06, Vol.41 (S2), p.834-835

2023

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Arylcyclopropanecarboxyl Guanidines as Novel, Potent, and Selective Inhibitors of the Sodium Hydrogen Exchanger Isoform-1

Journal of medicinal chemistry, 2001-09, Vol.44 (20), p.3302-3310

2001

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Cardioprotective effects of the potassium channel opener cromakalim: stereoselectivity and effects on myocardial adenine nucleotides

The Journal of pharmacology and experimental therapeutics, 1991-04, Vol.257 (1), p.156

1991

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Nucleotide Regulation and Characteristics of Potassium Channel Opener Binding to Skeletal Muscle Membranes

Molecular pharmacology, 1997-09, Vol.52 (3), p.473-481

1997

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Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines

Journal of medicinal chemistry, 1990-05, Vol.33 (5), p.1510-1515

1990

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Modulation of potassium channels by organic molecules

Medicinal research reviews, 1992-11, Vol.12 (6), p.569-591

Atwal, Karnail S.

1992

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Binding of ATP-Sensitive Potassium Channel (KATP) Openers to Cardiac Membranes: Correlation of Binding Affinities with Cardioprotective and Smooth Muscle Relaxing Potencies

Journal of medicinal chemistry, 1998-01, Vol.41 (3), p.271-275

1998

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Cardioprotective Profile of the Cardiac-Selective ATP-Sensitive Potassium Channel Opener BMS-180448

Journal of cardiovascular pharmacology, 1995-01, Vol.25 (1), p.40-50

1995

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Cardioselective Antiischemic ATP-Sensitive Potassium Channel (KA TP) Openers. 6. Effect of Modifications at C6 of Benzopyranyl Cyanoguanidines

Journal of medicinal chemistry, 1999-09, Vol.42 (18), p.3711-3717

1999

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Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents

Journal of medicinal chemistry, 1991-02, Vol.34 (2), p.806-811

1991

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Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents

Journal of medicinal chemistry, 1992-08, Vol.35 (17), p.3254-3263

1992

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Synthesis and biological activity of novel calcium channel blockers: 2,5-dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic acid esters and 2,5-dihydro-4-methyl-2-phenyl-1,5-benzodiazepine-3-carboxylic acid esters

Journal of medicinal chemistry, 1987-04, Vol.30 (4), p.635-640

1987

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Dihydropyrimidine calcium channel blockers. 2. 3-substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines

Journal of medicinal chemistry, 1990-09, Vol.33 (9), p.2629-2635

1990

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Myocardial Protection with the ATP-Sensitive Potassium Channel Openers

Current medicinal chemistry, 1996-08, Vol.3 (4), p.227-238

Atwal, Karnail S.

1996

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Cardioselective anti-ischemic ATP-sensitive potassium channel openers

Journal of medicinal chemistry, 1993-11, Vol.36 (24), p.3971-3974

1993

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Dihydropyrimidine angiotensin II receptor antagonists

Journal of medicinal chemistry, 1992-12, Vol.35 (25), p.4751-4763

1992

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Cardioselective Antiischemic ATP-Sensitive Potassium Channel (KATP) Openers. 5. Identification of 4-(N-Aryl)-Substituted Benzopyran Derivatives with High Selectivity

Journal of medicinal chemistry, 1997-01, Vol.40 (1), p.24-34

1997

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Cardioselective Antiischemic ATP-Sensitive Potassium Channel Openers. 2. Structure-Activity Studies on Benzopyranylcyanoguanidines; Modification of the Benzopyran Ring

Journal of medicinal chemistry, 1995-05, Vol.38 (11), p.1966-1973

1995

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Substituted 1,2,3,4-tetrahydroaminonaphthols: antihypertensive agents, calcium channel blockers, and adrenergic receptor blockers with catecholamine-depleting effects

Journal of medicinal chemistry, 1987-04, Vol.30 (4), p.627-635

1987

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Synthesis of substituted 1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid esters: the Biginelli condensation revisited

Heterocycles, 1987-05, Vol.26 (5), p.1185-1188

1987

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Treatment of Myocardial Ischemia with ATP-Sensitive Potassium Channel (KATP) Openers

Current pharmaceutical design, 1996-10, Vol.2 (5), p.585-595

1996

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Pharmacology and Structure-Activity Relationships for KATP Modulators: Tissue-Selective KATP Openers

Journal of cardiovascular pharmacology, 1994, Vol.24 Suppl 4, p.S12-S17

Atwal, Karnail S

1994

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Synthesis of substituted 1,2,3,4-tetrahydro-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid esters

Heterocycles, 1987-05, Vol.26 (5), p.1189-1192

1987

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Cardioselective Antiischemic ATP-Sensitive Potassium Channel Openers. 4. Structure−Activity Studies on Benzopyranylcyanoguanidines: Replacement of the Benzopyran Portion

Journal of medicinal chemistry, 1996-01, Vol.39 (1), p.304-313

1996

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A PHASE 1 STUDY EVALUATING PRT2527, A POTENT AND HIGHLY SELECTIVE CDK9 INHIBITOR, IN PATIENTS WITH SELECT RELAPSED/REFRACTORY B‐CELL MALIGNANCIES

PHASE 1 STUDY OF PRT1419 (MCL1 INHIBITOR) AS MONOTHERAPY OR IN COMBINATION WITH AZACITIDINE OR VENETOCLAX IN PATIENTS WITH RELAPSED/REFRACTORY MYELOID OR B‐CELL MALIGNANCIES

Arylcyclopropanecarboxyl Guanidines as Novel, Potent, and Selective Inhibitors of the Sodium Hydrogen Exchanger Isoform-1

Cardioprotective effects of the potassium channel opener cromakalim: stereoselectivity and effects on myocardial adenine nucleotides

Nucleotide Regulation and Characteristics of Potassium Channel Opener Binding to Skeletal Muscle Membranes

Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines

Modulation of potassium channels by organic molecules

Binding of ATP-Sensitive Potassium Channel (KATP) Openers to Cardiac Membranes: Correlation of Binding Affinities with Cardioprotective and Smooth Muscle Relaxing Potencies

Cardioprotective Profile of the Cardiac-Selective ATP-Sensitive Potassium Channel Opener BMS-180448

Cardioselective Antiischemic ATP-Sensitive Potassium Channel (KA TP) Openers. 6. Effect of Modifications at C6 of Benzopyranyl Cyanoguanidines

Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents

Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents

Synthesis and biological activity of novel calcium channel blockers: 2,5-dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic acid esters and 2,5-dihydro-4-methyl-2-phenyl-1,5-benzodiazepine-3-carboxylic acid esters

Dihydropyrimidine calcium channel blockers. 2. 3-substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines

Myocardial Protection with the ATP-Sensitive Potassium Channel Openers

Cardioselective anti-ischemic ATP-sensitive potassium channel openers

Dihydropyrimidine angiotensin II receptor antagonists

Cardioselective Antiischemic ATP-Sensitive Potassium Channel (KATP) Openers. 5. Identification of 4-(N-Aryl)-Substituted Benzopyran Derivatives with High Selectivity

Cardioselective Antiischemic ATP-Sensitive Potassium Channel Openers. 2. Structure-Activity Studies on Benzopyranylcyanoguanidines; Modification of the Benzopyran Ring

Substituted 1,2,3,4-tetrahydroaminonaphthols: antihypertensive agents, calcium channel blockers, and adrenergic receptor blockers with catecholamine-depleting effects

Synthesis of substituted 1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid esters: the Biginelli condensation revisited

Treatment of Myocardial Ischemia with ATP-Sensitive Potassium Channel (KATP) Openers

Pharmacology and Structure-Activity Relationships for KATP Modulators: Tissue-Selective KATP Openers

Synthesis of substituted 1,2,3,4-tetrahydro-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid esters

Cardioselective Antiischemic ATP-Sensitive Potassium Channel Openers. 4. Structure−Activity Studies on Benzopyranylcyanoguanidines: Replacement of the Benzopyran Portion

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