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Mechanisms of obesity-induced metabolic and vascular dysfunctions

Frontiers in bioscience, 2019-03, Vol.24 (5), p.890-934, Article 4758

2019

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Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1

Cardiovascular research, 2017-11, Vol.113 (13), p.1664-1676

2017

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Role of Arginase 2 in Systemic Metabolic Activity and Adipose Tissue Fatty Acid Metabolism in Diet-Induced Obese Mice

International journal of molecular sciences, 2019-03, Vol.20 (6), p.1462

2019

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Modulatory mechanisms of copperII-albumin complex toward N-nitrosodiethylamine-induced neurotoxicity in mice via regulating oxidative damage, inflammatory, and apoptotic signaling pathways

Ecotoxicology and environmental safety, 2024-01, Vol.270, p.115841-115841, Article 115841

2024

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The Long Noncoding RNA Cardiac Mesoderm Enhancer-Associated Noncoding RNA (Carmn) Is a Critical Regulator of Gastrointestinal Smooth Muscle Contractile Function and Motility

Gastroenterology (New York, N.Y. 1943), 2023-07, Vol.165 (1), p.71-87

2023

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Endothelial leptin receptor is dispensable for leptin-induced sympatho-activation and hypertension in male mice

Vascular pharmacology, 2022-10, Vol.146, p.107093-107093, Article 107093

2022

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In vivo and In silico evidence of the protective properties of carvacrol against experimentally induced gastric ulcer: Implication of antioxidant, anti-inflammatory, and antiapoptotic mechanisms

Chemico-biological interactions, 2023-09, Vol.382, p.110649-110649, Article 110649

2023

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Type 1 Diabetes Impairs Endothelium-Dependent Relaxation Via Increasing Endothelial Cell Glycolysis Through Advanced Glycation End Products, PFKFB3, and Nox1-Mediated Mechanisms

Hypertension (Dallas, Tex. 1979), 2023-10, Vol.80 (10), p.2059-2071

2023

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Deficiency of the novel high mobility group protein HMGXB4 protects against systemic inflammation-induced endotoxemia in mice

Proceedings of the National Academy of Sciences - PNAS, 2021-02, Vol.118 (7)

2021

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Age-Dependent Oxidative Stress Elevates Arginase 1 and Uncoupled Nitric Oxide Synthesis in Skeletal Muscle of Aged Mice

Oxidative medicine and cellular longevity, 2019-01, Vol.2019 (2019), p.1-9

2019

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Impairment in endothelial bioenergetics contributes to diabetes‐induced vascular dysfunction

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Nootkatone Mitigated Melamine-Evoked Hepatotoxicity by Featuring Oxidative Stress and Inflammation Interconnected Mechanisms: In Vivo and In Silico Approaches

Toxics (Basel), 2023-09, Vol.11 (9), p.784

2023

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Metformin Attenuates Testosterone-Induced Prostatic Hyperplasia in Rats: A Pharmacological Perspective

Scientific reports, 2015-10, Vol.5 (1), p.15639, Article 15639

2015

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Radioprotective Effects of Carvacrol and/or Thymol against Gamma Irradiation-Induced Acute Nephropathy: In Silico and In Vivo Evidence of the Involvement of Insulin-like Growth Factor-1 (IGF-1) and Calcitonin Gene-Related Peptide

Biomedicines, 2023-09, Vol.11 (9), p.2521

2023

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Role of the phytoestrogenic, pro-apoptotic and anti-oxidative properties of silymarin in inhibiting experimental benign prostatic hyperplasia in rats

Toxicology letters, 2013-05, Vol.219 (2), p.160-169

2013

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Telmisartan ameliorates carbon tetrachloride‐induced acute hepatotoxicity in rats

Environmental toxicology, 2017-02, Vol.32 (2), p.359-370

2017

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Role of Arginase 2 in Murine Retinopathy Associated with Western Diet-Induced Obesity

Journal of clinical medicine, 2020-01, Vol.9 (2), p.317

2020

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Modulatory effect of silymarin on inflammatory mediators in experimentally induced benign prostatic hyperplasia: emphasis on PTEN, HIF-1α, and NF-κB

Naunyn-Schmiedeberg's archives of pharmacology, 2014-12, Vol.387 (12), p.1131-1140

2014

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PFKFB3 Mediated Changes in ROS/NO Balance Contribute to Endothelial Dysfunction in Obesity

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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The Long Non-coding RNA Carmn is a Critical Regulator of Gastrointestinal Smooth Muscle Contractile Function and Motility

Gastroenterology (New York, N.Y. 1943), 2023-04, Vol.165 (1), p.71-87

2023

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Abstract P275: Deletion Of Endothelial Leptin Receptor Elevates Blood Pressure And Impairs Endothelial-dependent Relaxation Via Upregulation Of Endothelial Glycolytic Enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)

Hypertension (Dallas, Tex. 1979), 2021-09, Vol.78 (Suppl_1)

2021

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Critical role of arginase 2 in obesity‐induced metabolic dysregulation in female mice: Implication of macrophage inflammatory response

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Perivascular adipose tissue (PVAT)‐derived leptin improves aortic endothelial function via attenuating endothelial glycolysis in a mouse model of lipodystrophy

The FASEB journal, 2021-05, Vol.35 (S1), p.n/a, Article fasebj.2021.35.S1.02518

2021

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Type 1 Diabetes impairs vascular relaxation via increases in endothelial glycolysis and activation of the HIF1a-PFKFB3-Nox1 pathway in mice

Physiology (Bethesda, Md.), 2023-05, Vol.38 (S1)

2023

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Abstract 21290: Adipose Tissue Factors and the Adipokine Resistin-Induce Vascular Endothelial Dysfunction via Arginase Upregulation

Circulation (New York, N.Y.), 2017-11, Vol.136 (suppl_1)

2017

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Mechanisms of obesity-induced metabolic and vascular dysfunctions

Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1

Role of Arginase 2 in Systemic Metabolic Activity and Adipose Tissue Fatty Acid Metabolism in Diet-Induced Obese Mice

Modulatory mechanisms of copperII-albumin complex toward N-nitrosodiethylamine-induced neurotoxicity in mice via regulating oxidative damage, inflammatory, and apoptotic signaling pathways

The Long Noncoding RNA Cardiac Mesoderm Enhancer-Associated Noncoding RNA (Carmn) Is a Critical Regulator of Gastrointestinal Smooth Muscle Contractile Function and Motility

Endothelial leptin receptor is dispensable for leptin-induced sympatho-activation and hypertension in male mice

In vivo and In silico evidence of the protective properties of carvacrol against experimentally induced gastric ulcer: Implication of antioxidant, anti-inflammatory, and antiapoptotic mechanisms

Type 1 Diabetes Impairs Endothelium-Dependent Relaxation Via Increasing Endothelial Cell Glycolysis Through Advanced Glycation End Products, PFKFB3, and Nox1-Mediated Mechanisms

Deficiency of the novel high mobility group protein HMGXB4 protects against systemic inflammation-induced endotoxemia in mice

Age-Dependent Oxidative Stress Elevates Arginase 1 and Uncoupled Nitric Oxide Synthesis in Skeletal Muscle of Aged Mice

Impairment in endothelial bioenergetics contributes to diabetes‐induced vascular dysfunction

Nootkatone Mitigated Melamine-Evoked Hepatotoxicity by Featuring Oxidative Stress and Inflammation Interconnected Mechanisms: In Vivo and In Silico Approaches

Metformin Attenuates Testosterone-Induced Prostatic Hyperplasia in Rats: A Pharmacological Perspective

Radioprotective Effects of Carvacrol and/or Thymol against Gamma Irradiation-Induced Acute Nephropathy: In Silico and In Vivo Evidence of the Involvement of Insulin-like Growth Factor-1 (IGF-1) and Calcitonin Gene-Related Peptide

Role of the phytoestrogenic, pro-apoptotic and anti-oxidative properties of silymarin in inhibiting experimental benign prostatic hyperplasia in rats

Telmisartan ameliorates carbon tetrachloride‐induced acute hepatotoxicity in rats

Role of Arginase 2 in Murine Retinopathy Associated with Western Diet-Induced Obesity

Modulatory effect of silymarin on inflammatory mediators in experimentally induced benign prostatic hyperplasia: emphasis on PTEN, HIF-1α, and NF-κB

PFKFB3 Mediated Changes in ROS/NO Balance Contribute to Endothelial Dysfunction in Obesity

The Long Non-coding RNA Carmn is a Critical Regulator of Gastrointestinal Smooth Muscle Contractile Function and Motility

Abstract P275: Deletion Of Endothelial Leptin Receptor Elevates Blood Pressure And Impairs Endothelial-dependent Relaxation Via Upregulation Of Endothelial Glycolytic Enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)

Critical role of arginase 2 in obesity‐induced metabolic dysregulation in female mice: Implication of macrophage inflammatory response

Perivascular adipose tissue (PVAT)‐derived leptin improves aortic endothelial function via attenuating endothelial glycolysis in a mouse model of lipodystrophy

Type 1 Diabetes impairs vascular relaxation via increases in endothelial glycolysis and activation of the HIF1a-PFKFB3-Nox1 pathway in mice

Abstract 21290: Adipose Tissue Factors and the Adipokine Resistin-Induce Vascular Endothelial Dysfunction via Arginase Upregulation

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