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DNA Damage Detection and Repair Pathways—Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy

Clinical cancer research, 2008-07, Vol.14 (13), p.4032-4037

2008

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Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor

Journal of medicinal chemistry, 2020-02, Vol.63 (4), p.1612-1623

2020

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AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

Molecular cancer therapeutics, 2008-09, Vol.7 (9), p.2955-2966

2008

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Keeping checkpoint kinases in line: new selective inhibitors in clinical trials

Expert opinion on investigational drugs, 2008-09, Vol.17 (9), p.1331-1340

2008

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Discovery of a novel class of triazolones as Checkpoint Kinase inhibitors—Hit to lead exploration

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (17), p.5133-5138

2010

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Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors

Bioorganic & medicinal chemistry, 2008-07, Vol.18 (14), p.4242-4248

2008

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Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors

Journal of medicinal chemistry, 2019-07, Vol.62 (14), p.6575-6596

2019

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The identification and optimization of orally efficacious, small molecule VLA-4 antagonists

Current topics in medicinal chemistry, 2004-01, Vol.4 (14), p.1473

2004

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Strategies towards more effective anticancer therapies: targeting DNA damage response pathways

Expert review of clinical pharmacology, 2010-01, Vol.3 (1), p.103-115

Ashwell, Susan

2010

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Checkpoint kinase inhibitors: a review of the patent literature

Expert opinion on therapeutic patents, 2009-02, Vol.19 (2), p.165-197

2009

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Identification of Compounds with Nanomolar Binding Affinity for Checkpoint Kinase-1 Using Knowledge-Based Virtual Screening

Journal of medicinal chemistry, 2004-04, Vol.47 (8), p.1962-1968

2004

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Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors

Bioorganic & medicinal chemistry letters, 2012-03, Vol.22 (6), p.2330-2337

2012

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Preclinical pharmacokinetic/pharmacodynamic models to predict synergistic effects of co-administered anti-cancer agents

Cancer chemotherapy and pharmacology, 2010-07, Vol.66 (2), p.245-254

2010

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Caspases: recent advances in small molecule inhibitors

Expert opinion on therapeutic patents, 2001-10, Vol.11 (10), p.1593-1603

Ashwell, Susan

2001

Volltextzugriff (PDF)

Checkpoint Kinase and Wee1 Inhibitors as Anticancer Therapeutics

DNA Repair in Cancer Therapy, 2012, p.211-234

2012

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Chapter 10 - Checkpoint Kinase and Wee1 Inhibitors as Anticancer Therapeutics

DNA Repair in Cancer Therapy, 2012, p.211-234

Ashwell, Susan

2012

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Synthesis, characterization and evaluation of pro-drugs of VLA-4 antagonists

Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (7), p.1651-1654

2004

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Corrigendum to “Synthesis, characterization, and evaluation of pro-drugs of VLA-4 antagonists”

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (21), p.5449

2004

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Inhibitors of checkpoint kinases: from discovery to the clinic

Current opinion in drug discovery & development, 2007-07, Vol.10 (4), p.473

2007

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MODE OF ACTION OF VITAMIN B(12): MODEL STUDIES (VITAMIN B12)

ASHWELL, SUSAN

1989

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Model experiments pertaining to the mechanism of action of vitamin B 12 -dependent α-methyleneglutarate mutase

Journal of the Chemical Society. Chemical communications, 1989 (19), p.1483-1485

1989

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THE ENERGY COST OF FREE EXISTENCE FOR BERING SEA HARBOR AND SPOTTED SEALS

ASHWELL-ERICKSON, SUSAN MARIE

1981

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A Mechanistic Overview of B12‐dependent Processes

Vitamin B, 1998, p.201-216

1998

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Model experiments pertaining to the mechanism of action of vitamin B12-dependent α-methyleneglutarate mutase

Journal of the Chemical Society. Chemical communications, 1989-10 (19), p.1483-1485

1989

Volltextzugriff (PDF)

Effects of acute and chronic heat stress on the performance, egg quality, body temperature, and blood gas parameters of laying hens

Poultry science, 2019-12, Vol.98 (12), p.6684-6692

2019

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DNA Damage Detection and Repair Pathways—Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy

Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

Keeping checkpoint kinases in line: new selective inhibitors in clinical trials

Discovery of a novel class of triazolones as Checkpoint Kinase inhibitors—Hit to lead exploration

Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors

Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors

The identification and optimization of orally efficacious, small molecule VLA-4 antagonists

Strategies towards more effective anticancer therapies: targeting DNA damage response pathways

Checkpoint kinase inhibitors: a review of the patent literature

Identification of Compounds with Nanomolar Binding Affinity for Checkpoint Kinase-1 Using Knowledge-Based Virtual Screening

Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors

Preclinical pharmacokinetic/pharmacodynamic models to predict synergistic effects of co-administered anti-cancer agents

Caspases: recent advances in small molecule inhibitors

Checkpoint Kinase and Wee1 Inhibitors as Anticancer Therapeutics

Chapter 10 - Checkpoint Kinase and Wee1 Inhibitors as Anticancer Therapeutics

Synthesis, characterization and evaluation of pro-drugs of VLA-4 antagonists

Corrigendum to “Synthesis, characterization, and evaluation of pro-drugs of VLA-4 antagonists”

Inhibitors of checkpoint kinases: from discovery to the clinic

MODE OF ACTION OF VITAMIN B(12): MODEL STUDIES (VITAMIN B12)

Model experiments pertaining to the mechanism of action of vitamin B 12 -dependent α-methyleneglutarate mutase

THE ENERGY COST OF FREE EXISTENCE FOR BERING SEA HARBOR AND SPOTTED SEALS

A Mechanistic Overview of B12‐dependent Processes

Model experiments pertaining to the mechanism of action of vitamin B12-dependent α-methyleneglutarate mutase

Effects of acute and chronic heat stress on the performance, egg quality, body temperature, and blood gas parameters of laying hens

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