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Neprilysin Is Suppressed by Dual-Specificity Tyrosine-Phosphorylation Regulated Kinase 1A (DYRK1A) in Down-Syndrome-Derived Fibroblasts

Biological and Pharmaceutical Bulletin, 2017/03/01, Vol.40(3), pp.327-333

2017

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Molecular profiling of ginsenoside metabolites to identify estrogen receptor alpha activity

Gene, 2022-03, Vol.813, p.146108-146108, Article 146108

2022

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A New Species of Acoela Possessing a Middorsal Appendage with a Possible Sensory Function

Zoological science, 2022-02, Vol.39 (1), p.147

2022

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Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease

PloS one, 2011-09, Vol.6 (9), p.e25788-e25788

2011

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Long term administration of loquat leaves and their major component, ursolic acid, attenuated endogenous amyloid-β burden and memory impairment

Scientific reports, 2023-10, Vol.13 (1), p.16770-16770, Article 16770

2023

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A simplified and sensitive method to identify Alzheimer's disease biomarker candidates using patient-derived induced pluripotent stem cells (iPSCs)

Journal of biochemistry (Tokyo), 2017-12, Vol.162 (6), p.391-394

2017

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Paradigm shift from diagnosing patients based on common symptoms to categorizing patients into subtypes with different pathogenic mechanisms to guide treatment for Alzheimer's disease

Journal of biochemistry (Tokyo), 2017-06, Vol.161 (6), p.463-470

2017

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Perturbed Calcineurin-NFAT Signaling Is Associated with the Development of Alzheimer’s Disease

Biological and Pharmaceutical Bulletin, 2016/10/01, Vol.39(10), pp.1646-1652

2016

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Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

Scientific reports, 2013-03, Vol.3 (1), p.1472-1472, Article 1472

2013

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Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia

Nature communications, 2014-06, Vol.5 (1), p.3838-3838, Article 3838

2014

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Effect of the natural compound trans‑resveratrol on human MCM4 gene transcription

Oncology reports, 2020-07, Vol.44 (1), p.283-292

2020

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Characterization of the human zinc finger nfx‑1‑type containing 1 encoding ZNFX1 gene and its response to 12‑O‑tetradecanoyl‑13‑acetate in HL‑60 cells

International journal of oncology, 2019-10, Vol.55 (4), p.896-904

2019

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An NAD + dependent/sensitive transcription system: Toward a novel anti-cancer therapy

AIMS molecular science, 2020-01, Vol.7 (1), p.12-28

2020

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Characterization of the human IDH1 gene promoter

AIMS molecular science, 2023-01, Vol.10 (3), p.186-204

2023

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ダウン症患者における早期アルツハイマー病発症メカニズムの解明

YAKUGAKU ZASSHI, 2017/07/01, Vol.137(7), pp.801-805

2017

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KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (6), p.1527-1531

2004

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A new topical gene C9orf72 in neurodegenerative diseases

Folia Pharmacologica Japonica, 2015, Vol.145(1), pp.44-44

Asai, Masashi

2015

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A pathogenic mechanism of N-terminally pyroglutamylated Aβ and possible application of Alzheimer's disease by inhibition of the pyroglutamylation

Rinsho shinkeigaku = Clinical neurology, 2012, Vol.52 (11), p.1162

2012

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Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

Cell stem cell, 2013-04, Vol.12 (4), p.487-496

2013

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Cathepsin B inhibitor CA-074Me causes the accumulation of APP C-terminal fragments independently of secretases activities

Neuroscience research, 2009, Vol.65, p.S64-S64

2009

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Induction of the human CDC45 gene promoter activity by natural compound trans ‑resveratrol

Molecular medicine reports, 2024-06, Vol.29 (6)

2024

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Elucidating Pathogenic Mechanisms of Early-onset Alzheimer's Disease in Down Syndrome Patients

YAKUGAKU ZASSHI, 2017/07/01, Vol.137(7), pp.801-805

2017

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Berberine alters the processing of Alzheimer’s amyloid precursor protein to decrease Aβ secretion

Biochemical and biophysical research communications, 2007-01, Vol.352 (2), p.498-502

2007

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An alternative metabolic pathway of amyloid precursor protein C‐terminal fragments via cathepsin B in a human neuroglioma model

The FASEB journal, 2011-10, Vol.25 (10), p.3720-3730

2011

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Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase

Biochemical and biophysical research communications, 2003-01, Vol.301 (1), p.231-235

2003

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Neprilysin Is Suppressed by Dual-Specificity Tyrosine-Phosphorylation Regulated Kinase 1A (DYRK1A) in Down-Syndrome-Derived Fibroblasts

Molecular profiling of ginsenoside metabolites to identify estrogen receptor alpha activity

A New Species of Acoela Possessing a Middorsal Appendage with a Possible Sensory Function

Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease

Long term administration of loquat leaves and their major component, ursolic acid, attenuated endogenous amyloid-β burden and memory impairment

A simplified and sensitive method to identify Alzheimer's disease biomarker candidates using patient-derived induced pluripotent stem cells (iPSCs)

Paradigm shift from diagnosing patients based on common symptoms to categorizing patients into subtypes with different pathogenic mechanisms to guide treatment for Alzheimer's disease

Perturbed Calcineurin-NFAT Signaling Is Associated with the Development of Alzheimer’s Disease

Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia

Effect of the natural compound trans‑resveratrol on human MCM4 gene transcription

Characterization of the human zinc finger nfx‑1‑type containing 1 encoding ZNFX1 gene and its response to 12‑O‑tetradecanoyl‑13‑acetate in HL‑60 cells

An NAD + dependent/sensitive transcription system: Toward a novel anti-cancer therapy

Characterization of the human IDH1 gene promoter

ダウン症患者における早期アルツハイマー病発症メカニズムの解明

KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine

A new topical gene C9orf72 in neurodegenerative diseases

A pathogenic mechanism of N-terminally pyroglutamylated Aβ and possible application of Alzheimer's disease by inhibition of the pyroglutamylation

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

Cathepsin B inhibitor CA-074Me causes the accumulation of APP C-terminal fragments independently of secretases activities

Induction of the human CDC45 gene promoter activity by natural compound trans ‑resveratrol

Elucidating Pathogenic Mechanisms of Early-onset Alzheimer's Disease in Down Syndrome Patients

Berberine alters the processing of Alzheimer’s amyloid precursor protein to decrease Aβ secretion

An alternative metabolic pathway of amyloid precursor protein C‐terminal fragments via cathepsin B in a human neuroglioma model

Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase

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