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Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant

Journal of enzyme inhibition and medicinal chemistry, 2019-01, Vol.34 (1), p.631-637

2019

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Coumarin Compounds in Medicinal Chemistry: Some Important Examples from the Last Years

Current topics in medicinal chemistry, 2018-01, Vol.18 (2), p.124-148

2018

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The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure

European journal of medicinal chemistry, 2021-02, Vol.212, p.113123-113123, Article 113123

2021

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Characterization of amide bond conformers for a novel heterocyclic template of N-acylhydrazone derivatives

Molecules (Basel, Switzerland), 2013-09, Vol.18 (10), p.11683-11704

2013

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Recent Advances in Microwave-Assisted Synthesis and Functionalization of 1,2,3- and 1,2,4-triazoles

Current organic chemistry, 2021-12, Vol.25 (23), p.2815-2839

2021

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The Design of Multi-target Drugs to Treat Cardiovascular Diseases: Two (or more) Birds on One Stone

Current topics in medicinal chemistry, 2022-03, Vol.22 (5), p.366-394

2022

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Design, Synthesis and Biological Evaluation of Novel Triazole N -acylhydrazone Hybrids for Alzheimer's Disease

Molecules (Basel, Switzerland), 2020-07, Vol.25 (14), p.3165

2020

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Microwave-assisted synthesis and photophysical studies of novel fluorescent N-acylhydrazone and semicarbazone-7-OH-coumarin dyes

New journal of chemistry, 2016, Vol.40 (10), p.8846-8854

2016

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Theory Behind Biginelli Reaction Revisited

Revista Virtual de Química, 2019-07, Vol.11 (4), p.1203-1224

2019

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Antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor

European journal of medicinal chemistry, 2012-09, Vol.55, p.49-57

2012

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DEAD/DIAD - More than Simple Mitsunobu Reagents

Synlett, 2008-10, Vol.2008 (17), p.2723-2724

Kümmerle, Arthur

2008

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Anti-atherogenic Effects of a New Thienylacylhydrazone Derivative, LASSBio-788, in Rats Fed a Hypercholesterolemic Diet

Journal of Pharmacological Sciences, 2013/09/20, Vol.123(1), pp.47-57

2013

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Development of a L‐Tryptophan‐Based Ligand for Regioselective Copper Catalyzed N 2 ‐Arylation of 1,2,3‐Triazoles

ChemistrySelect (Weinheim), 2017-07, Vol.2 (22), p.6544-6548

2017

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PDE4 inhibitors: From Discovery and Announced Failure to its Resurgence

Revista Virtual de Química, 2015-03, Vol.7 (2)

2015

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Cinnamoyl-N-Acylhydrazone-Donepezil Hybrids: Synthesis and Evaluation of Novel Multifunctional Ligands Against Neurodegenerative Diseases

Neurochemical research, 2020-12, Vol.45 (12), p.3003-3020

2020

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Regioselective microwave synthesis and derivatization of 1,5-diaryl-3-amino-1,2,4-triazoles and a study of their cholinesterase inhibition properties

RSC advances, 2019-07, Vol.9 (35), p.2356-2369

2019

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Synthesis and mechanism of novel fluorescent coumarin–dihydropyrimidinone dyads obtained by the Biginelli multicomponent reaction

New journal of chemistry, 2015-01, Vol.39 (3), p.2323-2332

2015

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Microwave-assisted synthesis and photophysical studies of novel fluorescent N-acylhydrazone and semicarbazone-7-OH-coumarin dyesElectronic supplementary information (ESI) available: NMR and mass spectra, HPLC analyses, additional figures as mentioned in the text. See DOI: 10.1039/c6nj01532h

2016-10

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Design, synthesis and antiproliferative evaluation of new acridine-thiosemicarbazone derivatives as topoisomerase IIα inhibitors

Results in Chemistry, 2024-01, Vol.7, p.101371, Article 101371

2024

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Synthesis and mechanism of novel fluorescent coumarin-dihydropyrimidinone dyads obtained by the Biginelli multicomponent reactionElectronic supplementary information (ESI) available: NMR and mass spectra, HPLC analyses, additional figures and crystallographic data as mentioned in the text. CCDC 1025676. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4nj02155j

2015-03

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N-acylhydrazone improves exercise intolerance in rats submitted to myocardial infarction by the recovery of calcium homeostasis in skeletal muscle

Life sciences (1973), 2014-01, Vol.94 (1), p.30-36

2014

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Vasodilator and antihypertensive effects of a novel N-acylhydrazone derivative mediated by the inhibition of L-type Ca2+ channels

Fundamental & clinical pharmacology, 2014-02, Vol.28 (1), p.29-41

2014

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Development of a L‐Tryptophan‐Based Ligand for Regioselective Copper Catalyzed N2‐Arylation of 1,2,3‐Triazoles

ChemistrySelect (Weinheim), 2017-07, Vol.2 (22), p.6544-6548

2017

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O uso de aparelhos de micro-ondas domésticos em aulas experimentais de química orgânica: nitração de salicilaldeído

Química Nova, 2010, Vol.33 (7), p.1603-1606

2010

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Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant

Coumarin Compounds in Medicinal Chemistry: Some Important Examples from the Last Years

The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure

Characterization of amide bond conformers for a novel heterocyclic template of N-acylhydrazone derivatives

Recent Advances in Microwave-Assisted Synthesis and Functionalization of 1,2,3- and 1,2,4-triazoles

The Design of Multi-target Drugs to Treat Cardiovascular Diseases: Two (or more) Birds on One Stone

Design, Synthesis and Biological Evaluation of Novel Triazole N -acylhydrazone Hybrids for Alzheimer's Disease

Microwave-assisted synthesis and photophysical studies of novel fluorescent N-acylhydrazone and semicarbazone-7-OH-coumarin dyes

Theory Behind Biginelli Reaction Revisited

Antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor

DEAD/DIAD - More than Simple Mitsunobu Reagents

Anti-atherogenic Effects of a New Thienylacylhydrazone Derivative, LASSBio-788, in Rats Fed a Hypercholesterolemic Diet

Development of a L‐Tryptophan‐Based Ligand for Regioselective Copper Catalyzed N 2 ‐Arylation of 1,2,3‐Triazoles

PDE4 inhibitors: From Discovery and Announced Failure to its Resurgence

Cinnamoyl-N-Acylhydrazone-Donepezil Hybrids: Synthesis and Evaluation of Novel Multifunctional Ligands Against Neurodegenerative Diseases

Regioselective microwave synthesis and derivatization of 1,5-diaryl-3-amino-1,2,4-triazoles and a study of their cholinesterase inhibition properties

Synthesis and mechanism of novel fluorescent coumarin–dihydropyrimidinone dyads obtained by the Biginelli multicomponent reaction

Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation

Microwave-assisted synthesis and photophysical studies of novel fluorescent N-acylhydrazone and semicarbazone-7-OH-coumarin dyesElectronic supplementary information (ESI) available: NMR and mass spectra, HPLC analyses, additional figures as mentioned in the text. See DOI: 10.1039/c6nj01532h

Design, synthesis and antiproliferative evaluation of new acridine-thiosemicarbazone derivatives as topoisomerase IIα inhibitors

N-acylhydrazone improves exercise intolerance in rats submitted to myocardial infarction by the recovery of calcium homeostasis in skeletal muscle

Vasodilator and antihypertensive effects of a novel N-acylhydrazone derivative mediated by the inhibition of L-type Ca2+ channels

Development of a L‐Tryptophan‐Based Ligand for Regioselective Copper Catalyzed N2‐Arylation of 1,2,3‐Triazoles

O uso de aparelhos de micro-ondas domésticos em aulas experimentais de química orgânica: nitração de salicilaldeído

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