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Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5673-5698

2017

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Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases

Journal of medicinal chemistry, 2020-11, Vol.63 (22), p.13561-13577

2020

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Oxidative Cyclization Approach to Benzimidazole Libraries

ACS combinatorial science, 2020-01, Vol.22 (1), p.1-5

2020

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Diastereoselective Synthesis of 2,3,6-Trisubstituted Piperidines

Journal of organic chemistry, 2009-06, Vol.74 (12), p.4525-4536

2009

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Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor

Journal of medicinal chemistry, 2018-04, Vol.61 (8), p.3753-3753

2018

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In pursuit of α4β2 nicotinic receptor partial agonists for smoking cessation: Carbon analogs of (−)-cytisine

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (12), p.2974-2979

2005

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3,5-Bicyclic aryl piperidines: A novel class of α4β2 neuronal nicotinic receptor partial agonists for smoking cessation

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (22), p.4889-4897

2005

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Total Synthesis of (±)-Cytisine

Organic letters, 2000-12, Vol.2 (26), p.4201-4204

2000

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Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates - subtype selective, high affinity alpha 7 nicotinic acetylcholine receptor agonists

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4747-4751

2009

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Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates – subtype selective, high affinity α7 nicotinic acetylcholine receptor agonists

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4747-4751

2009

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Steric redirection of alkylation in 1H-pyrazole-3-carboxylate esters

Tetrahedron letters, 2018-01, Vol.59 (4), p.402-405

2018

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Steric redirection of alkylation in 1 H -pyrazole-3-carboxylate esters

Tetrahedron letters, 2018-01, Vol.59 (4), p.402-405

2018

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Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation

Journal of medicinal chemistry, 2005-05, Vol.48 (10), p.3474-3477

2005

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Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1

MedChemComm, 2014, Vol.5 (9), p.1290-1296

2014

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ChemInform Abstract: Facile Synthesis of 2,4-Disubstituted Thiooxazoles and 2,4-Disubstituted Oxazole Sulfonyl Chlorides via Acyl Isothiocyanates and TMS-Diazomethane

ChemInform, 2015-12, Vol.46 (50), p.no-no

2015

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Pyridine analogs of (−)-cytisine and varenicline: cholinergic receptor probes

Tetrahedron letters, 2008-05, Vol.49 (21), p.3368-3371

2008

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Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1Electronic supplementary information (ESI) available: Broad panel ligand-receptor binding data, PDE1 assay data with standard error, select pharmacokinetic data for 7a and 27, X-ray crystal structure experimental information for 7a and 27, PDE1B1 enzyme purity data and binding assay protocol, and complete synthesis experimental details. The crystal structure of inhibitor 7a bou

2014-08

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Low efficacy partial agonists of the α4β2 nicotinic acetylcholine receptor (nAChR). Does functional efficacy govern in vivo response?

Biochemical pharmacology, 2009-10, Vol.78 (7), p.919-919

2009

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Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation

Journal of medicinal chemistry, 2005-05, Vol.48 (10), p.3474-3477

2005

Volltextzugriff (PDF)

Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4747-4751

2009

Volltextzugriff (PDF)

3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (22), p.4889-4897

2005

Volltextzugriff (PDF)

In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (12), p.2974-2979

2005

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ChemInform Abstract: Total Synthesis of (.+-.)-Cytisine

ChemInform, 2001-04, Vol.32 (16), p.no-no

2001

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Lung Microbiota Contribute to Pulmonary Inflammation and Disease Progression in Pulmonary Fibrosis

American journal of respiratory and critical care medicine, 2019-05, Vol.199 (9), p.1127-1138

2019

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ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Radiological, Nuclear Medicine and Hybrid Imaging

Neuroendocrinology, 2017-01, Vol.105 (3), p.212-244

2017

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Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor

Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases

Oxidative Cyclization Approach to Benzimidazole Libraries

Diastereoselective Synthesis of 2,3,6-Trisubstituted Piperidines

Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor

In pursuit of α4β2 nicotinic receptor partial agonists for smoking cessation: Carbon analogs of (−)-cytisine

3,5-Bicyclic aryl piperidines: A novel class of α4β2 neuronal nicotinic receptor partial agonists for smoking cessation

Total Synthesis of (±)-Cytisine

Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates - subtype selective, high affinity alpha 7 nicotinic acetylcholine receptor agonists

Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates – subtype selective, high affinity α7 nicotinic acetylcholine receptor agonists

Steric redirection of alkylation in 1H-pyrazole-3-carboxylate esters

Steric redirection of alkylation in 1 H -pyrazole-3-carboxylate esters

Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation

Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1

ChemInform Abstract: Facile Synthesis of 2,4-Disubstituted Thiooxazoles and 2,4-Disubstituted Oxazole Sulfonyl Chlorides via Acyl Isothiocyanates and TMS-Diazomethane

Pyridine analogs of (−)-cytisine and varenicline: cholinergic receptor probes

Low efficacy partial agonists of the α4β2 nicotinic acetylcholine receptor (nAChR). Does functional efficacy govern in vivo response?

Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation

Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists

3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation

In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine

ChemInform Abstract: Total Synthesis of (.+-.)-Cytisine

Lung Microbiota Contribute to Pulmonary Inflammation and Disease Progression in Pulmonary Fibrosis

ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Radiological, Nuclear Medicine and Hybrid Imaging

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