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Neuronal nicotinic receptors: A perspective on two decades of drug discovery research

Biochemical pharmacology, 2007-10, Vol.74 (8), p.1092-1101

2007

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Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker

The Journal of pharmacology and experimental therapeutics, 2010-08, Vol.334 (2), p.545-555

2010

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Role of voltage-gated calcium channels in ascending pain pathways

Brain Research Reviews, 2009-04, Vol.60 (1), p.84-89

2009

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A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain

Pain (Amsterdam), 2011-04, Vol.152 (4), p.833-843

2011

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Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis

JAMA neurology, 2017-10, Vol.74 (10), p.1178

2017

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Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: A View of the Regulatory Science Qualification Landscape from the Coalition Against Major Diseases CSF Biomarker Team

Journal of Alzheimer's disease, 2017-01, Vol.55 (1), p.19-35

2017

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Evolving cancer pain treatments: rational approaches to improve the quality of life for cancer patients

Current pharmaceutical biotechnology, 2011-10, Vol.12 (10), p.1627-1643

2011

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Emerging Molecular Approaches to Pain Therapy

Journal of medicinal chemistry, 1999-05, Vol.42 (9), p.1481-1500

1999

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Antagonism of CRF2 receptors produces anxiolytic behavior in animal models of anxiety

Brain research, 2001-06, Vol.902 (2), p.135-142

2001

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Regulatory-accepted drug development tools are needed to accelerate innovative CNS disease treatments

Biochemical pharmacology, 2018-05, Vol.151, p.291-306

2018

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Biometric monitoring devices for assessing end points in clinical trials: developing an ecosystem

Nature reviews. Drug discovery, 2017-10, Vol.16 (10), p.736-736

2017

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Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 receptors in rats

The Journal of pharmacology and experimental therapeutics, 2004-04, Vol.309 (1), p.293

2004

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Characterization of the substituted N-triazole oxindole TROX-1, a small-molecule, state-dependent inhibitor of Ca(V)2 calcium channels

Molecular pharmacology, 2012-03, Vol.81 (3), p.488-497

2012

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Role of the Nucleus Raphe Magnus in Antinociception Produced by ABT-594: Immediate Early Gene Responses Possibly Linked to Neuronal Nicotinic Acetylcholine Receptors on Serotonergic Neurons

The Journal of neuroscience, 1998-07, Vol.18 (14), p.5426-5432

1998

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Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship

Journal of medicinal chemistry, 2006-07, Vol.49 (14), p.4425-4436

2006

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Tailoring chronic pain treatments for the elderly: are we prepared for the challenge?

Drug discovery today, 2014-01, Vol.19 (1), p.8-17

2014

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In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418

Brain research, 1996-05, Vol.719 (1), p.36-44

1996

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Synthesis and Structure−Activity Relationships of 8-(Pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: Potent, Orally Bioavailable Corticotropin Releasing Factor Receptor-1 (CRF1) Antagonists

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.3084-3092

2009

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Neuroimaging of Pain: Advances and Future Prospects

The journal of pain, 2008-07, Vol.9 (7), p.567-579

2008

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8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: Selective and Centrally Active Corticotropin-Releasing Factor Receptor-1 (CRF1) Antagonists

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.3073-3083

2009

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Treatments for neuropathic pain differentially affect delayed matching accuracy by macaques: effects of amitriptyline and gabapentin

Pain (Amsterdam), 2010-03, Vol.148 (3), p.446-453

2010

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Human α4β2 Neuronal Nicotinic Acetylcholine Receptor in HEK 293 Cells: A Patch-Clamp Study

The Journal of neuroscience, 1996-12, Vol.16 (24), p.7880-7891

1996

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Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-(( S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist

Bioorganic & medicinal chemistry letters, 1998-02, Vol.8 (3), p.249-254

1998

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Diversity of neuronal nicotinic acetylcholine receptors: Lessons from behavior and implications for cns therapeutics

Life Sciences, 1995, Vol.56 (8), p.545-570

1995

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A fluorescence-based high-throughput screening assay for the identification of T-type calcium channel blockers

Assay and drug development technologies, 2009-06, Vol.7 (3), p.266-280

2009

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Neuronal nicotinic receptors: A perspective on two decades of drug discovery research

Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker

Role of voltage-gated calcium channels in ascending pain pathways

A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain

Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis

Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: A View of the Regulatory Science Qualification Landscape from the Coalition Against Major Diseases CSF Biomarker Team

Evolving cancer pain treatments: rational approaches to improve the quality of life for cancer patients

Emerging Molecular Approaches to Pain Therapy

Antagonism of CRF2 receptors produces anxiolytic behavior in animal models of anxiety

Regulatory-accepted drug development tools are needed to accelerate innovative CNS disease treatments

Biometric monitoring devices for assessing end points in clinical trials: developing an ecosystem

Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 receptors in rats

Characterization of the substituted N-triazole oxindole TROX-1, a small-molecule, state-dependent inhibitor of Ca(V)2 calcium channels

Role of the Nucleus Raphe Magnus in Antinociception Produced by ABT-594: Immediate Early Gene Responses Possibly Linked to Neuronal Nicotinic Acetylcholine Receptors on Serotonergic Neurons

Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship

Tailoring chronic pain treatments for the elderly: are we prepared for the challenge?

In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418

Synthesis and Structure−Activity Relationships of 8-(Pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: Potent, Orally Bioavailable Corticotropin Releasing Factor Receptor-1 (CRF1) Antagonists

Neuroimaging of Pain: Advances and Future Prospects

8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: Selective and Centrally Active Corticotropin-Releasing Factor Receptor-1 (CRF1) Antagonists

Treatments for neuropathic pain differentially affect delayed matching accuracy by macaques: effects of amitriptyline and gabapentin

Human α4β2 Neuronal Nicotinic Acetylcholine Receptor in HEK 293 Cells: A Patch-Clamp Study

Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-(( S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist

Diversity of neuronal nicotinic acetylcholine receptors: Lessons from behavior and implications for cns therapeutics

A fluorescence-based high-throughput screening assay for the identification of T-type calcium channel blockers

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