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Broad-Spectrum, Non-Opioid Analgesic Activity by Selective Modulation of Neuronal Nicotinic Acetylcholine Receptors

Science (American Association for the Advancement of Science), 1998-01, Vol.279 (5347), p.77-81

1998

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Emerging Molecular Approaches to Pain Therapy

Journal of medicinal chemistry, 1999-05, Vol.42 (9), p.1481-1500

1999

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Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis

The Journal of neuroscience, 1990-07, Vol.10 (7), p.2363-2372

1990

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ABT-594, a novel cholinergic channel modulator, is efficacious in nerve ligation and diabetic neuropathy models of neuropathic pain

Brain research, 1998-08, Vol.801 (1), p.158-163

1998

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Identification and Initial Structure−Activity Relationships of (R)-5-(2-Azetidinylmethoxy)-2-chloropyridine (ABT-594), a Potent, Orally Active, Non-Opiate Analgesic Agent Acting via Neuronal Nicotinic Acetylcholine Receptors

Journal of medicinal chemistry, 1998-02, Vol.41 (4), p.407-412

1998

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Role of voltage-gated calcium channels in ascending pain pathways

Brain Research Reviews, 2009-04, Vol.60 (1), p.84-89

2009

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Nicotinic receptor binding of [ 3H]cytisine, [ 3H]nicotine and [ 3H]methylcarbamylcholine in rat brain

European journal of pharmacology, 1994-03, Vol.253 (3), p.261-267

1994

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In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418

Brain research, 1996-05, Vol.719 (1), p.36-44

1996

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Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys

Psychopharmacologia, 1998-03, Vol.136 (1), p.50-58

1998

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(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization

The Journal of pharmacology and experimental therapeutics, 1994-07, Vol.270 (1), p.310

1994

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Anxiolytic-like effects of the novel cholinergic channel activator ABT-418

The Journal of pharmacology and experimental therapeutics, 1994-10, Vol.271 (1), p.353

1994

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Presenilin-1 and -2 Are Molecular Targets for γ-Secretase Inhibitors

The Journal of biological chemistry, 2000-11, Vol.275 (44), p.34086-34091

2000

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Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice

European journal of pharmacology, 1998-04, Vol.346 (1), p.23-33

1998

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Effects of lobeline, a nicotinic receptor agonist, on learning and memory

Pharmacology, biochemistry and behavior, 1993-07, Vol.45 (3), p.571-576

1993

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Nicotinic agonists modulate basal forebrain control of cortical cerebral blood flow in anesthetized rats

The Journal of pharmacology and experimental therapeutics, 1993-10, Vol.267 (1), p.440

1993

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Effects of ABT-418, a novel cholinergic channel ligand, on place learning in septal-lesioned rats

European journal of pharmacology, 1994-08, Vol.261 (1), p.217-222

1994

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Novel Isoxazoles which Interact with Brain Cholinergic Channel Receptors Have Intrinsic Cognitive Enhancing and Anxiolytic Activities

Journal of medicinal chemistry, 1994-04, Vol.37 (8), p.1055-1059

1994

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Evidence for Nicotinic Receptors Potentially Modulating Nociceptive Transmission at the Level of the Primary Sensory Neuron: Studies with F11 Cells

Journal of neurochemistry, 1997-09, Vol.69 (3), p.930-938

1997

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Structure−Activity Studies on 2-Methyl-3-(2(S)-pyrrolidinylmethoxy)pyridine (ABT-089): An Orally Bioavailable 3-Pyridyl Ether Nicotinic Acetylcholine Receptor Ligand with Cognition-Enhancing Properties

Journal of medicinal chemistry, 1997-01, Vol.40 (3), p.385-390

1997

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Nitric oxide synthase is critical in mediating basal forebrain regulation of cortical cerebral circulation

Journal of neuroscience research, 1992-09, Vol.33 (1), p.129-135

1992

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Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: Effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (19), p.2797-2802

1998

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Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-(( S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist

Bioorganic & medicinal chemistry letters, 1998-02, Vol.8 (3), p.249-254

1998

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Characterization of [3H]ABT-418: a novel cholinergic channel ligand

The Journal of pharmacology and experimental therapeutics, 1995-06, Vol.273 (3), p.1434

1995

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Improvement in accuracy of delayed recall in aged and non-aged, mature monkeys after intramuscular or transdermal administration of the CNS nicotinic receptor agonist ABT-418

Psychopharmacologia, 1997-04, Vol.130 (3), p.276-284

1997

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Diversity of neuronal nicotinic acetylcholine receptors: Lessons from behavior and implications for cns therapeutics

Life Sciences, 1995, Vol.56 (8), p.545-570

1995

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Broad-Spectrum, Non-Opioid Analgesic Activity by Selective Modulation of Neuronal Nicotinic Acetylcholine Receptors

Emerging Molecular Approaches to Pain Therapy

Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis

ABT-594, a novel cholinergic channel modulator, is efficacious in nerve ligation and diabetic neuropathy models of neuropathic pain

Identification and Initial Structure−Activity Relationships of (R)-5-(2-Azetidinylmethoxy)-2-chloropyridine (ABT-594), a Potent, Orally Active, Non-Opiate Analgesic Agent Acting via Neuronal Nicotinic Acetylcholine Receptors

Role of voltage-gated calcium channels in ascending pain pathways

Nicotinic receptor binding of [ 3H]cytisine, [ 3H]nicotine and [ 3H]methylcarbamylcholine in rat brain

In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418

Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys

(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization

Anxiolytic-like effects of the novel cholinergic channel activator ABT-418

Presenilin-1 and -2 Are Molecular Targets for γ-Secretase Inhibitors

Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice

Effects of lobeline, a nicotinic receptor agonist, on learning and memory

Nicotinic agonists modulate basal forebrain control of cortical cerebral blood flow in anesthetized rats

Effects of ABT-418, a novel cholinergic channel ligand, on place learning in septal-lesioned rats

Novel Isoxazoles which Interact with Brain Cholinergic Channel Receptors Have Intrinsic Cognitive Enhancing and Anxiolytic Activities

Evidence for Nicotinic Receptors Potentially Modulating Nociceptive Transmission at the Level of the Primary Sensory Neuron: Studies with F11 Cells

Structure−Activity Studies on 2-Methyl-3-(2(S)-pyrrolidinylmethoxy)pyridine (ABT-089): An Orally Bioavailable 3-Pyridyl Ether Nicotinic Acetylcholine Receptor Ligand with Cognition-Enhancing Properties

Nitric oxide synthase is critical in mediating basal forebrain regulation of cortical cerebral circulation

Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: Effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice

Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-(( S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist

Characterization of [3H]ABT-418: a novel cholinergic channel ligand

Improvement in accuracy of delayed recall in aged and non-aged, mature monkeys after intramuscular or transdermal administration of the CNS nicotinic receptor agonist ABT-418

Diversity of neuronal nicotinic acetylcholine receptors: Lessons from behavior and implications for cns therapeutics

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