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Regulatory-accepted drug development tools are needed to accelerate innovative CNS disease treatments

Biochemical pharmacology, 2018-05, Vol.151, p.291-306

2018

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Biometric monitoring devices for assessing end points in clinical trials: developing an ecosystem

Nature reviews. Drug discovery, 2017-10, Vol.16 (10), p.736-736

2017

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Neuronal nicotinic receptors: A perspective on two decades of drug discovery research

Biochemical pharmacology, 2007-10, Vol.74 (8), p.1092-1101

2007

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Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: A View of the Regulatory Science Qualification Landscape from the Coalition Against Major Diseases CSF Biomarker Team

Journal of Alzheimer's disease, 2017-01, Vol.55 (1), p.19-35

2017

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Concise informed consent to increase data and biospecimen access may accelerate innovative Alzheimer's disease treatments

Alzheimer's & dementia : translational research & clinical interventions, 2017-11, Vol.3 (4), p.536-541

2017

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Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker

The Journal of pharmacology and experimental therapeutics, 2010-08, Vol.334 (2), p.545-555

2010

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Accelerating drug development for Alzheimer's disease through the use of data standards

Alzheimer's & dementia : translational research & clinical interventions, 2017-06, Vol.3 (2), p.273-283

2017

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Role of voltage-gated calcium channels in ascending pain pathways

Brain Research Reviews, 2009-04, Vol.60 (1), p.84-89

2009

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A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain

Pain (Amsterdam), 2011-04, Vol.152 (4), p.833-843

2011

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Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis

JAMA neurology, 2017-10, Vol.74 (10), p.1178

2017

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Regulatory Science Objectives and Biomarker Qualification Through Public-Private Partnerships Are Critical to Delivering Innovative Treatments for CNS Diseases

Handbook of Behavioral Neuroscience, 2019, Vol.29, p.277-296

2019

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Evolving cancer pain treatments: rational approaches to improve the quality of life for cancer patients

Current pharmaceutical biotechnology, 2011-10, Vol.12 (10), p.1627-1643

2011

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Emerging Molecular Approaches to Pain Therapy

Journal of medicinal chemistry, 1999-05, Vol.42 (9), p.1481-1500

1999

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Antagonism of CRF2 receptors produces anxiolytic behavior in animal models of anxiety

Brain research, 2001-06, Vol.902 (2), p.135-142

2001

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Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 receptors in rats

The Journal of pharmacology and experimental therapeutics, 2004-04, Vol.309 (1), p.293

2004

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Characterization of the substituted N-triazole oxindole TROX-1, a small-molecule, state-dependent inhibitor of Ca(V)2 calcium channels

Molecular pharmacology, 2012-03, Vol.81 (3), p.488-497

2012

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THE CRITICAL PATH FOR ALZHEIMER’S DISEASE (CPAD) CONSORTIUM – A PRE-COMPETITIVE, GLOBAL, INTEGRATED, AND STANDARDIZED ALZHEIMER DISEASE CLINICAL TRIAL DATA SHARING REPOSITORY TO SUPPORT AD DRUG DEVELOPMENT

Alzheimer's & dementia, 2019-07, Vol.15 (7), p.P1376-P1377

2019

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P4‐253: THE CRITICAL PATH FOR ALZHEIMER'S DISEASE (CPAD) CONSORTIUM – A PRE‐COMPETITIVE, GLOBAL, INTEGRATED, AND STANDARDIZED ALZHEIMER DISEASE CLINICAL TRIAL DATA SHARING REPOSITORY TO SUPPORT AD DRUG DEVELOPMENT

Alzheimer's & dementia, 2019-07, Vol.15 (7S_Part_26), p.P1376-P1377

2019

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Role of the Nucleus Raphe Magnus in Antinociception Produced by ABT-594: Immediate Early Gene Responses Possibly Linked to Neuronal Nicotinic Acetylcholine Receptors on Serotonergic Neurons

The Journal of neuroscience, 1998-07, Vol.18 (14), p.5426-5432

1998

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Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship

Journal of medicinal chemistry, 2006-07, Vol.49 (14), p.4425-4436

2006

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Tailoring chronic pain treatments for the elderly: are we prepared for the challenge?

Drug discovery today, 2014-01, Vol.19 (1), p.8-17

2014

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P4‐090: THE CRITICAL PATH FOR ALZHEIMER'S DISEASE (CPAD) CONSORTIUM: FACILITATING RAPID DATA AND INFORMATION SHARING BY ESTABLISHING A SUSTAINABLE, INTEGRATED, AND STANDARDIZED PLATFORM ADVANCING KNOWLEDGE TO ENABLE EXPEDITED DRUG DEVELOPMENT

Alzheimer's & dementia, 2018-07, Vol.14 (7S_Part_28), p.P1470-P1471

2018

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In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418

Brain research, 1996-05, Vol.719 (1), p.36-44

1996

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Synthesis and Structure−Activity Relationships of 8-(Pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: Potent, Orally Bioavailable Corticotropin Releasing Factor Receptor-1 (CRF1) Antagonists

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.3084-3092

2009

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Neuroimaging of Pain: Advances and Future Prospects

The journal of pain, 2008-07, Vol.9 (7), p.567-579

2008

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Regulatory-accepted drug development tools are needed to accelerate innovative CNS disease treatments

Biometric monitoring devices for assessing end points in clinical trials: developing an ecosystem

Neuronal nicotinic receptors: A perspective on two decades of drug discovery research

Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: A View of the Regulatory Science Qualification Landscape from the Coalition Against Major Diseases CSF Biomarker Team

Concise informed consent to increase data and biospecimen access may accelerate innovative Alzheimer's disease treatments

Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker

Accelerating drug development for Alzheimer's disease through the use of data standards

Role of voltage-gated calcium channels in ascending pain pathways

A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain

Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis

Regulatory Science Objectives and Biomarker Qualification Through Public-Private Partnerships Are Critical to Delivering Innovative Treatments for CNS Diseases

Evolving cancer pain treatments: rational approaches to improve the quality of life for cancer patients

Emerging Molecular Approaches to Pain Therapy

Antagonism of CRF2 receptors produces anxiolytic behavior in animal models of anxiety

Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 receptors in rats

Characterization of the substituted N-triazole oxindole TROX-1, a small-molecule, state-dependent inhibitor of Ca(V)2 calcium channels

THE CRITICAL PATH FOR ALZHEIMER’S DISEASE (CPAD) CONSORTIUM – A PRE-COMPETITIVE, GLOBAL, INTEGRATED, AND STANDARDIZED ALZHEIMER DISEASE CLINICAL TRIAL DATA SHARING REPOSITORY TO SUPPORT AD DRUG DEVELOPMENT

P4‐253: THE CRITICAL PATH FOR ALZHEIMER'S DISEASE (CPAD) CONSORTIUM – A PRE‐COMPETITIVE, GLOBAL, INTEGRATED, AND STANDARDIZED ALZHEIMER DISEASE CLINICAL TRIAL DATA SHARING REPOSITORY TO SUPPORT AD DRUG DEVELOPMENT

Role of the Nucleus Raphe Magnus in Antinociception Produced by ABT-594: Immediate Early Gene Responses Possibly Linked to Neuronal Nicotinic Acetylcholine Receptors on Serotonergic Neurons

Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship

Tailoring chronic pain treatments for the elderly: are we prepared for the challenge?

P4‐090: THE CRITICAL PATH FOR ALZHEIMER'S DISEASE (CPAD) CONSORTIUM: FACILITATING RAPID DATA AND INFORMATION SHARING BY ESTABLISHING A SUSTAINABLE, INTEGRATED, AND STANDARDIZED PLATFORM ADVANCING KNOWLEDGE TO ENABLE EXPEDITED DRUG DEVELOPMENT

In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418

Synthesis and Structure−Activity Relationships of 8-(Pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: Potent, Orally Bioavailable Corticotropin Releasing Factor Receptor-1 (CRF1) Antagonists

Neuroimaging of Pain: Advances and Future Prospects

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