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Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-IgE antibody, in atopic subjects

Clinical and experimental allergy, 2014-11, Vol.44 (11), p.1371-1385

2014

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Down-regulation of leucocyte immunoglobulin-like receptor expression in the synovium of rheumatoid arthritis patients after treatment with disease-modifying anti-rheumatic drugs

Rheumatology (Oxford, England), 2007-05, Vol.46 (5), p.742-751

2007

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Sorting out the cytokines of asthma

The Journal of experimental medicine, 1996-01, Vol.183 (1), p.1-5

1996

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Chemical mutational analysis of the human glucocorticoid receptor cDNA in glucocorticoid-resistant bronchial asthma

American journal of respiratory cell and molecular biology, 1994-07, Vol.11 (1), p.42

1994

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Effect of the 5-lipoxygenase inhibitor ZD2138 on aspirin-induced asthma

Thorax, 1994-08, Vol.49 (8), p.749-756

1994

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Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4

Immunogenetics (New York), 2000-07, Vol.51 (8-9), p.659-669

2000

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IgE-dependent activation of cytokine-primed mouse cultured mast cells induces a delayed phase of prostaglandin D2 generation via prostaglandin endoperoxide synthase-2

The Journal of immunology (1950), 1995-11, Vol.155 (9), p.4445

1995

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Cloning of the gp49B gene of the immunoglobulin superfamily and demonstration that one of its two products is an early-expressed mast cell surface protein originally described as gp49

The Journal of biological chemistry, 1994-03, Vol.269 (11), p.8393-8401

1994

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The Pathobiology of Bronchial Asthma

Advances in Immunology, 1992, Vol.51, p.323-382

1992

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Effect of the 5-lipoxygenase inhibitor ZD2138 on allergen-induced early and late asthmatic responses

Thorax, 1994-08, Vol.49 (8), p.743-748

1994

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Sulphidopeptide leukotrienes in asthma

Clinical science (1979), 1993-05, Vol.84 (5), p.501

1993

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Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells

The Journal of biological chemistry, 1994-09, Vol.269 (35), p.22269-22275

1994

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The effects of inhaled leukotriene E4 on the airway responsiveness to histamine in subjects with asthma and normal subjects

Journal of allergy and clinical immunology, 1988-10, Vol.82 (4), p.654-660

1988

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Molecular cloning of gp49, a cell-surface antigen that is preferentially expressed by mouse mast cell progenitors and is a new member of the immunoglobulin superfamily

The Journal of biological chemistry, 1991-08, Vol.266 (24), p.15966-15973

1991

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Effect of dietary supplementation with fish oil lipids on mild asthma

Thorax, 1988-02, Vol.43 (2), p.84-92

1988

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The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase

The Journal of experimental medicine, 1995-07, Vol.182 (1), p.197-206

1995

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Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor

The Journal of immunology (1950), 1997-09, Vol.159 (5), p.2342

1997

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Characterization of leukotriene B3: comparison of its biological activities with leukotriene B4 and leukotriene B5 in complement receptor enhancement, lysozyme release and chemotaxis of human neutrophils

Clinical science (1979), 1988-05, Vol.74 (5), p.467

1988

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Maturation-related changes in the expression of Fc gamma RII and Fc gamma RIII on mouse mast cells derived in vitro and in vivo

The Journal of immunology (1950), 1990-11, Vol.145 (10), p.3412

1990

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Regulation of Prostaglandin Endoperoxide Synthase-2 and IL-6 Expression in Mouse Bone Marrow-Derived Mast Cells by Exogenous But Not Endogenous Prostanoids

The Journal of immunology (1950), 2002-02, Vol.168 (3), p.1397-1404

2002

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Intracellular degradation of Fc gamma RIII in mouse bone marrow culture-derived progenitor mast cells prevents its surface expression and associated function

The Journal of biological chemistry, 1993-01, Vol.268 (2), p.1207-1212

1993

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The relative responsiveness to inhaled leukotriene E4, methacholine and histamine in normal and asthmatic subjects

The European respiratory journal, 1988-12, Vol.1 (10), p.913-917

1988

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Low molecular weight group IIA and group V phospholipase A(2) enzymes have different intracellular locations in mouse bone marrow-derived mast cells

The Journal of biological chemistry, 1999-10, Vol.274 (44), p.31476-31484

1999

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Mediator release in aspirin-induced reactions

Journal of allergy and clinical immunology, 1991-12, Vol.88 (6), p.827-829

1991

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A32 NEW ASTHMA THERAPIES: CLINICAL STUDIES: Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of Qge031, A High Affinity Anti-Ige Antibody In Caucasian And Japanese Atopic Subjects

American journal of respiratory and critical care medicine, 2014-01, Vol.189, p.1

2014

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Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-IgE antibody, in atopic subjects

Down-regulation of leucocyte immunoglobulin-like receptor expression in the synovium of rheumatoid arthritis patients after treatment with disease-modifying anti-rheumatic drugs

Sorting out the cytokines of asthma

Chemical mutational analysis of the human glucocorticoid receptor cDNA in glucocorticoid-resistant bronchial asthma

Effect of the 5-lipoxygenase inhibitor ZD2138 on aspirin-induced asthma

Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4

IgE-dependent activation of cytokine-primed mouse cultured mast cells induces a delayed phase of prostaglandin D2 generation via prostaglandin endoperoxide synthase-2

Cloning of the gp49B gene of the immunoglobulin superfamily and demonstration that one of its two products is an early-expressed mast cell surface protein originally described as gp49

The Pathobiology of Bronchial Asthma

Effect of the 5-lipoxygenase inhibitor ZD2138 on allergen-induced early and late asthmatic responses

Sulphidopeptide leukotrienes in asthma

Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells

The effects of inhaled leukotriene E4 on the airway responsiveness to histamine in subjects with asthma and normal subjects

Molecular cloning of gp49, a cell-surface antigen that is preferentially expressed by mouse mast cell progenitors and is a new member of the immunoglobulin superfamily

Effect of dietary supplementation with fish oil lipids on mild asthma

The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase

Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor

Characterization of leukotriene B3: comparison of its biological activities with leukotriene B4 and leukotriene B5 in complement receptor enhancement, lysozyme release and chemotaxis of human neutrophils

Maturation-related changes in the expression of Fc gamma RII and Fc gamma RIII on mouse mast cells derived in vitro and in vivo

Regulation of Prostaglandin Endoperoxide Synthase-2 and IL-6 Expression in Mouse Bone Marrow-Derived Mast Cells by Exogenous But Not Endogenous Prostanoids

Intracellular degradation of Fc gamma RIII in mouse bone marrow culture-derived progenitor mast cells prevents its surface expression and associated function

The relative responsiveness to inhaled leukotriene E4, methacholine and histamine in normal and asthmatic subjects

Low molecular weight group IIA and group V phospholipase A(2) enzymes have different intracellular locations in mouse bone marrow-derived mast cells

Mediator release in aspirin-induced reactions

A32 NEW ASTHMA THERAPIES: CLINICAL STUDIES: Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of Qge031, A High Affinity Anti-Ige Antibody In Caucasian And Japanese Atopic Subjects

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