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New 3-Alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-Dioxide Derivatives Activate ATP-Sensitive Potassium Channels of Pancreatic Beta Cells

Journal of medicinal chemistry, 2006-07, Vol.49 (14), p.4127-4139

2006

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6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-Dioxide Derivatives Potently and Selectively Activate ATP Sensitive Potassium Channels of Pancreatic β-Cells

Journal of medicinal chemistry, 2002-09, Vol.45 (19), p.4171-4187

2002

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Inhibition of insulin secretion as a new drug target in the treatment of metabolic disorders

Current medicinal chemistry, 2004-06, Vol.11 (12), p.1595

2004

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Possible role of an ischemic preconditioning-like response mechanism in KATP channel opener-mediated protection against streptozotocin-induced suppression of rat pancreatic islet function

Biochemical pharmacology, 2008-12, Vol.76 (12), p.1748-1756

2008

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Identification of Akt Pathway Inhibitors Using Redistribution Screening on the FLIPR and the IN Cell 3000 Analyzer

Journal of biomolecular screening, 2005-02, Vol.10 (1), p.20-29

2005

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Possible role of an ischemic preconditioning-like response mechanism in K(ATP) channel opener-mediated protection against streptozotocin-induced suppression of rat pancreatic islet function

Biochemical pharmacology, 2008-12, Vol.76 (12), p.1748-1756

2008

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Synthesis and pharmacological evaluation of 4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels

Bioorganic & medicinal chemistry, 2005-01, Vol.13 (1), p.141-155

2005

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Arylcyanoguanidines as Activators of Kir6.2/SUR1KATP Channels and Inhibitors of Insulin Release

Journal of medicinal chemistry, 2004-06, Vol.47 (12), p.3202-3211

2004

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Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release

Journal of medicinal chemistry, 2004-06, Vol.47 (12), p.3202-3211

2004

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Dihydroxyacetone-induced Oscillations in Cytoplasmic Free Ca2+ and the ATP/ADP Ratio in Pancreatic β-Cells at Substimulatory Glucose

The Journal of biological chemistry, 2003-10, Vol.278 (42), p.40710-40716

2003

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2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K(ATP) channels

Bioorganic & medicinal chemistry letters, 2004-12, Vol.14 (23), p.5727-5730

2004

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2-(4-methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 KATP channels

Bioorganic & medicinal chemistry letters, 2004-12, Vol.14 (23), p.5727-5730

2004

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Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells

Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (13), p.1749-1752

2001

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Glucose- and Interleukin-1β-Induced β-Cell Apoptosis Requires Ca2+ Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a Sulfonylurea Receptor 1/Inwardly Rectifying K+ Channel 6.2 (SUR/Kir6.2) Selective Potassium Channel Opener in Human Islets

Diabetes (New York, N.Y.), 2004-07, Vol.53 (7), p.1706-1713

2004

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New 3-Alkylamino-4 H -thieno-1,2,4-thiadiazine 1,1-Dioxide Derivatives Activate ATP-Sensitive Potassium Channels of Pancreatic Beta Cells

Journal of medicinal chemistry, 2006-07, Vol.49 (14), p.4127-4139

2006

Volltextzugriff (PDF)

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets

Diabetes (New York, N.Y.), 2004-07, Vol.53 (7), p.1706

2004

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Simultaneous visualization of the translocation of protein kinase Cα–green fluorescent protein hybrids and intracellular calcium concentrations

Biochemical journal, 1999-01, Vol.337 (2), p.211-218

1999

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6-Chloro-3-alkylamino-4 H -thieno[3,2 -e ]-1,2,4-thiadiazine 1,1-Dioxide Derivatives Potently and Selectively Activate ATP Sensitive Potassium Channels of Pancreatic β-Cells

Journal of medicinal chemistry, 2002-09, Vol.45 (19), p.4171-4187

2002

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2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide Activates Kir6.2/SUR1 KATP Channels

ChemInform, 2005-03, Vol.36 (13), p.no-no

2005

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2‐(4‐Methoxyphenoxy)‐5‐nitro‐N‐(4‐sulfamoylphenyl)benzamide Activates Kir6.2/SUR1 K ATP Channels

ChemInform, 2005-03, Vol.36 (13)

2005

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ChemInform Abstract: Phenylcyanoguanidines as Inhibitors of Glucose-Induced Insulin Secretion from Beta Cells

ChemInform, 2001-11, Vol.32 (47), p.no-no

2001

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Long-Term Safety of Roflumilast in Patients with Chronic Obstructive Pulmonary Disease, a Multinational Observational Database Cohort Study

International journal of chronic obstructive pulmonary disease, 2024-08, Vol.19, p.1879-1892

2024

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Separation of the Glucose-Stimulated Cytoplasmic and Mitochondrial NAD(P)H Responses in Pancreatic Islet β Cells

Proceedings of the National Academy of Sciences - PNAS, 2000-05, Vol.97 (10), p.5203-5207

2000

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Pancreatic islets cultured on extracellular matrix : An excellent preparation for microfluorometry

Methods in cell science, 1998-12, Vol.19 (4), p.255-268

1998

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New 3-Alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-Dioxide Derivatives Activate ATP-Sensitive Potassium Channels of Pancreatic Beta Cells

6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-Dioxide Derivatives Potently and Selectively Activate ATP Sensitive Potassium Channels of Pancreatic β-Cells

Inhibition of insulin secretion as a new drug target in the treatment of metabolic disorders

Possible role of an ischemic preconditioning-like response mechanism in KATP channel opener-mediated protection against streptozotocin-induced suppression of rat pancreatic islet function

Identification of Akt Pathway Inhibitors Using Redistribution Screening on the FLIPR and the IN Cell 3000 Analyzer

Possible role of an ischemic preconditioning-like response mechanism in K(ATP) channel opener-mediated protection against streptozotocin-induced suppression of rat pancreatic islet function

Synthesis and pharmacological evaluation of 4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels

Arylcyanoguanidines as Activators of Kir6.2/SUR1KATP Channels and Inhibitors of Insulin Release

Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release

Dihydroxyacetone-induced Oscillations in Cytoplasmic Free Ca2+ and the ATP/ADP Ratio in Pancreatic β-Cells at Substimulatory Glucose

2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K(ATP) channels

2-(4-methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 KATP channels

Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells

Glucose- and Interleukin-1β-Induced β-Cell Apoptosis Requires Ca2+ Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a Sulfonylurea Receptor 1/Inwardly Rectifying K+ Channel 6.2 (SUR/Kir6.2) Selective Potassium Channel Opener in Human Islets

New 3-Alkylamino-4 H -thieno-1,2,4-thiadiazine 1,1-Dioxide Derivatives Activate ATP-Sensitive Potassium Channels of Pancreatic Beta Cells

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets

Simultaneous visualization of the translocation of protein kinase Cα–green fluorescent protein hybrids and intracellular calcium concentrations

6-Chloro-3-alkylamino-4 H -thieno[3,2 -e ]-1,2,4-thiadiazine 1,1-Dioxide Derivatives Potently and Selectively Activate ATP Sensitive Potassium Channels of Pancreatic β-Cells

2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide Activates Kir6.2/SUR1 KATP Channels

2‐(4‐Methoxyphenoxy)‐5‐nitro‐N‐(4‐sulfamoylphenyl)benzamide Activates Kir6.2/SUR1 K ATP Channels

ChemInform Abstract: Phenylcyanoguanidines as Inhibitors of Glucose-Induced Insulin Secretion from Beta Cells

Long-Term Safety of Roflumilast in Patients with Chronic Obstructive Pulmonary Disease, a Multinational Observational Database Cohort Study

Separation of the Glucose-Stimulated Cytoplasmic and Mitochondrial NAD(P)H Responses in Pancreatic Islet β Cells

Pancreatic islets cultured on extracellular matrix : An excellent preparation for microfluorometry

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