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Nonnucleoside Reverse Transcriptase Inhibitors that Potently and Specifically Block Human Immunodeficiency Virus Type 1 Replication

Proceedings of the National Academy of Sciences - PNAS, 1991-10, Vol.88 (19), p.8806-8810

1991

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Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class

Journal of medicinal chemistry, 1998-08, Vol.41 (18), p.3467-3476

1998

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The benzylthio-pyrimidine U-31,355, a potent inhibitor of HIV-1 reverse transcriptase

Biochemical pharmacology, 1996-03, Vol.51 (6), p.743-750

1996

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U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication

Antimicrobial Agents and Chemotherapy, 1993-05, Vol.37 (5), p.1127-1131

1993

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Molecular basis for sequence-specific DNA alkylation by CC-1065

Biochemistry (Easton), 1988-05, Vol.27 (10), p.3886-3892

1988

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Steady-state kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-87201E

The Journal of biological chemistry, 1993-03, Vol.268 (9), p.6119-6124

1993

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Kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-88204E

Biochemistry (Easton), 1993-07, Vol.32 (26), p.6548-6554

1993

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Structure-Based Design of HIV Protease Inhibitors: 5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors

Journal of medicinal chemistry, 1996-11, Vol.39 (23), p.4630-4642

1996

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Interstrand DNA cross-linking with dimers of the spirocyclopropyl alkylating moiety of CC-1065

Journal of the American Chemical Society, 1989-08, Vol.111 (16), p.6428-6429

1989

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The chemistry of DNA modification by antitumor antibiotics

Progress in drug research, 1988, Vol.32, p.411

1988

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K252a, KT5720, KT5926, and U98017 support paclitaxel (taxol)-dependent cells and synergize with paclitaxel

Cancer research (Chicago, Ill.), 1994-11, Vol.54 (22), p.5889-5894

1994

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Synthesis of CBI-PDE-I-dimer, the benzannelated analog of CC-1065

Journal of organic chemistry, 1992-11, Vol.57 (23), p.6234-6239

1992

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The quinoline U-78036 is a potent inhibitor of HIV-1 reverse transcriptase

The Journal of biological chemistry, 1993-07, Vol.268 (20), p.14875-14880

1993

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Sequence-selective guanine reactivity by duocarmycin A

Chemical research in toxicology, 1993-07, Vol.6 (4), p.421-424

1993

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Steady-state kinetic studies with the polysulfonate U-9843, and HIV reverse transcriptase inhibitor

Experientia, 1994-01, Vol.50 (1), p.23-28

1994

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Kinetic studies with the non-nucleoside human immunodeficiency virus type-1 reverse transcriptase inhibitor U-90152E

Biochemical pharmacology, 1994-06, Vol.47 (11), p.2017-2028

1994

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Stereochemistry, total synthesis, and biological activity of 14,15-dihydroxy-5,8,10,12-eicosatetraenoic acid

The Journal of biological chemistry, 1984-11, Vol.259 (21), p.13011-13016

1984

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Characterization of B16 melanoma cells resistant to the CC-1065 analogue U-71,184

Cancer research (Chicago, Ill.), 1990-04, Vol.50 (8), p.2485-2492

1990

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Synthesis and biochemical evaluation of the CBI-PDE-I-dimer, a benzannelated analog of (+)-CC-1065 that also produces delayed toxicity in mice

Journal of medicinal chemistry, 1993-07, Vol.36 (14), p.1956-1963

1993

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Synthesis of prostacyclin analogs

Advances in prostaglandin, thromboxane, and leukotriene research, 1985, Vol.14, p.309

Aristoff, P A

1985

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Oxazolidinones: a new class of antibacterials

Current Opinion in Pharmacology, 2001-10, Vol.1 (5), p.470-476

2001

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Cytoprotective and antisecretory properties of a non-diarrheogenic and non-uterotonic prostacyclin analog: U-68, 215

Prostaglandins, 1985-10, Vol.30 (4), p.619-649

1985

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Enzymatic kinetic studies with the non-nucleoside HIV reverse transcriptase inhibitor U-9843

Experientia, 1992-12, Vol.48 (11-12), p.1127-1132

1992

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Coupling of cyclopropapyrroloindole (CPI) derivatives. The preparation of CC-1065, ent-CC-1065, and analogs

Journal of the American Chemical Society, 1987-10, Vol.109 (22), p.6837-6838

1987

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Nonnucleoside Reverse Transcriptase Inhibitors that Potently and Specifically Block Human Immunodeficiency Virus Type 1 Replication

Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class

The benzylthio-pyrimidine U-31,355, a potent inhibitor of HIV-1 reverse transcriptase

U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication

Molecular basis for sequence-specific DNA alkylation by CC-1065

Steady-state kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-87201E

Kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-88204E

Structure-Based Design of Nonpeptidic HIV Protease Inhibitors: The Sulfonamide-Substituted Cyclooctylpyranones

Structure-Based Design of HIV Protease Inhibitors: 5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors

Interstrand DNA cross-linking with dimers of the spirocyclopropyl alkylating moiety of CC-1065

The chemistry of DNA modification by antitumor antibiotics

K252a, KT5720, KT5926, and U98017 support paclitaxel (taxol)-dependent cells and synergize with paclitaxel

Synthesis of CBI-PDE-I-dimer, the benzannelated analog of CC-1065

The quinoline U-78036 is a potent inhibitor of HIV-1 reverse transcriptase

Sequence-selective guanine reactivity by duocarmycin A

Steady-state kinetic studies with the polysulfonate U-9843, and HIV reverse transcriptase inhibitor

Kinetic studies with the non-nucleoside human immunodeficiency virus type-1 reverse transcriptase inhibitor U-90152E

Stereochemistry, total synthesis, and biological activity of 14,15-dihydroxy-5,8,10,12-eicosatetraenoic acid

Characterization of B16 melanoma cells resistant to the CC-1065 analogue U-71,184

Synthesis and biochemical evaluation of the CBI-PDE-I-dimer, a benzannelated analog of (+)-CC-1065 that also produces delayed toxicity in mice

Synthesis of prostacyclin analogs

Oxazolidinones: a new class of antibacterials

Cytoprotective and antisecretory properties of a non-diarrheogenic and non-uterotonic prostacyclin analog: U-68, 215

Enzymatic kinetic studies with the non-nucleoside HIV reverse transcriptase inhibitor U-9843

Coupling of cyclopropapyrroloindole (CPI) derivatives. The preparation of CC-1065, ent-CC-1065, and analogs

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