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Negative regulation of type I IFN signaling

Journal of leukocyte biology, 2018-06, Vol.103 (6), p.1099-1116

2018

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Identification and characterization of a novel ISG15-ubiquitin mixed chain and its role in regulating protein homeostasis

Scientific reports, 2015-07, Vol.5 (1), p.12704-12704, Article 12704

2015

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STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

Nature structural & molecular biology, 2017-03, Vol.24 (3), p.279

2017

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Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125

Proceedings of the National Academy of Sciences - PNAS, 2007-05, Vol.104 (18), p.7500-7505

2007

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Emerging role of immunogenic cell death in cancer immunotherapy

Frontiers in immunology, 2024, Vol.15, p.1390263-1390263

2024

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Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18

Cell reports (Cambridge), 2023-12, Vol.42 (12), p.113560-113560, Article 113560

2023

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Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis

Nature communications, 2023-01, Vol.14 (1), p.251-251, Article 251

2023

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Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN‐λ and elevated secretion of Cxcl10

EMBO molecular medicine, 2013-07, Vol.5 (7), p.1035-1050

2013

Volltextzugriff (PDF)

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense

Proceedings of the National Academy of Sciences - PNAS, 2010-09, Vol.107 (36), p.15856-15861

2010

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Plakophilin-2 Promotes Tumor Development by Enhancing Ligand-Dependent and -Independent Epidermal Growth Factor Receptor Dimerization and Activation

Molecular and cellular biology, 2014-10, Vol.34 (20), p.3843-3854

2014

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Cell-cycle-gated feedback control mediates desensitization to interferon stimulation

eLife, 2020-09, Vol.9

2020

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Type I IFN induces protein ISGylation to enhance cytokine expression and augments colonic inflammation

Proceedings of the National Academy of Sciences - PNAS, 2015-11, Vol.112 (46), p.14313-14318

2015

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Rho Guanine Nucleotide Exchange Factors Regulate Horizontal Axon Branching of Cortical Upper Layer Neurons

Cerebral cortex (New York, N.Y. 1991), 2020-04, Vol.30 (4), p.2506-2518

2020

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Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell-Mediated Tumor Killing

Cancer discovery, 2020-03, Vol.10 (3), p.382-393

2020

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Hippo kinase loss contributes to del(20q) hematologic malignancies through chronic innate immune activation

Blood, 2019-11, Vol.134 (20), p.1730-1744

2019

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Interferon-mediated ISG15 conjugation restricts dengue virus 2 replication

Biochemical and biophysical research communications, 2014-05, Vol.448 (1), p.95-100

2014

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Elevated Response to Type I IFN Enhances RANKL-Mediated Osteoclastogenesis in Usp18-Knockout Mice

The Journal of immunology (1950), 2016-05, Vol.196 (9), p.3887-3895

2016

Volltextzugriff (PDF)

The RUNX1-ETO target gene RASSF2 suppresses t(8;21) AML development and regulates Rac GTPase signaling

Blood cancer journal (New York), 2020-02, Vol.10 (2), p.16, Article 16

2020

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UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I

Molecular immunology, 2008-02, Vol.45 (4), p.1078-1084

2008

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Murine Herc6 Plays a Critical Role in Protein ISGylation In Vivo and Has an ISGylation-Independent Function in Seminal Vesicles

Journal of interferon & cytokine research, 2015-05, Vol.35 (5), p.351

2015

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The probacterial effect of type I interferon signaling requires its own negative regulator USP18

Science immunology, 2018-09, Vol.3 (27)

2018

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Identification of Compounds That Prolong Type I Interferon Signaling as Potential Vaccine Adjuvants

SLAS discovery, 2018-10, Vol.23 (9), p.960-973

2018

Volltextzugriff (PDF)

Galectin-1 Induces Cell Adhesion to the Extracellular Matrix and Apoptosis of Non-Adherent Human Colon Cancer Colo201 Cells

Journal of biochemistry (Tokyo), 2003-12, Vol.134 (6), p.869-874

2003

Volltextzugriff (PDF)

Hypersensitivity to type I interferon as a cause of hydrocephalus development

Brain research, 2024-10, Vol.1840, p.149082, Article 149082

2024

Volltextzugriff (PDF)

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Negative regulation of type I IFN signaling

Identification and characterization of a novel ISG15-ubiquitin mixed chain and its role in regulating protein homeostasis

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125

Emerging role of immunogenic cell death in cancer immunotherapy

Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18

Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis

Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN‐λ and elevated secretion of Cxcl10

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense

Plakophilin-2 Promotes Tumor Development by Enhancing Ligand-Dependent and -Independent Epidermal Growth Factor Receptor Dimerization and Activation

Cell-cycle-gated feedback control mediates desensitization to interferon stimulation

Type I IFN induces protein ISGylation to enhance cytokine expression and augments colonic inflammation

Rho Guanine Nucleotide Exchange Factors Regulate Horizontal Axon Branching of Cortical Upper Layer Neurons

Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell-Mediated Tumor Killing

Hippo kinase loss contributes to del(20q) hematologic malignancies through chronic innate immune activation

Interferon-mediated ISG15 conjugation restricts dengue virus 2 replication

Elevated Response to Type I IFN Enhances RANKL-Mediated Osteoclastogenesis in Usp18-Knockout Mice

The RUNX1-ETO target gene RASSF2 suppresses t(8;21) AML development and regulates Rac GTPase signaling

UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I

Murine Herc6 Plays a Critical Role in Protein ISGylation In Vivo and Has an ISGylation-Independent Function in Seminal Vesicles

The probacterial effect of type I interferon signaling requires its own negative regulator USP18

Identification of Compounds That Prolong Type I Interferon Signaling as Potential Vaccine Adjuvants

Galectin-1 Induces Cell Adhesion to the Extracellular Matrix and Apoptosis of Non-Adherent Human Colon Cancer Colo201 Cells

Hypersensitivity to type I interferon as a cause of hydrocephalus development

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