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Randomised clinical trial: anti‐viral activity of ANA773, an oral inducer of endogenous interferons acting via TLR7, in chronic HCV

Alimentary pharmacology & therapeutics, 2011-08, Vol.34 (4), p.443-453

2011

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The pharmacology of endosomal TLR agonists in viral disease

Biochemical Society transactions, 2007-12, Vol.35 (Pt 6), p.1468-1472

2007

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Methotrexate-resistant variants of human dihydrofolate reductase. Effects of Phe31 substitutions

The Journal of biological chemistry, 1994-04, Vol.269 (13), p.9547-9555

1994

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Kinetics of the formation and isomerization of methotrexate complexes of recombinant human dihydrofolate reductase

The Journal of biological chemistry, 1988-07, Vol.263 (21), p.10304-10313

1988

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Role of aspartate 27 in the binding of methotrexate to dihydrofolate reductase from Escherichia coli

The Journal of biological chemistry, 1988-07, Vol.263 (19), p.9187-9198

1988

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Unusual transient- and steady-state kinetic behavior is predicted by the kinetic scheme operational for recombinant human dihydrofolate reductase

The Journal of biological chemistry, 1990-02, Vol.265 (5), p.2740-2748

1990

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Rapid diagnostics: the detection of neuraminidase activity as a technology for high-specificity targets

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2001-12, Vol.356 (1416), p.1925-1931

2001

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AMP Deaminase Inhibitors. 2. Initial Discovery of a Non-Nucleotide Transition-State Inhibitor Series

Journal of medicinal chemistry, 2000-04, Vol.43 (8), p.1495-1507

2000

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AMP Deaminase Inhibitors. 3. SAR of 3-(Carboxyarylalkyl)coformycin Aglycon Analogues

Journal of medicinal chemistry, 2000-04, Vol.43 (8), p.1508-1518

2000

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Role of aspartate 27 of dihydrofolate reductase from Escherichia coli in interconversion of active and inactive enzyme conformers and binding of NADPH

The Journal of biological chemistry, 1990-04, Vol.265 (10), p.5579-5584

1990

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Hydride transfer by dihydrofolate reductase. Causes and consequences of the wide range of rates exhibited by bacterial and vertebrate enzymes

The Journal of biological chemistry, 1989-06, Vol.264 (16), p.9391-9399

1989

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Rapid kinetics of the glucose transporter from human erythrocytes. Detection and measurement of a half-turnover of the purified transporter

The Journal of biological chemistry, 1985-04, Vol.260 (8), p.4575-4578

1985

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Insulin stimulates fluid-phase endocytosis and exocytosis in 3T3-L1 adipocytes

The Journal of biological chemistry, 1986-03, Vol.261 (9), p.3944-3951

1986

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Atypical transient state kinetics of recombinant human dihydrofolate reductase produced by hysteretic behavior. Comparison with dihydrofolate reductases from other sources

The Journal of biological chemistry, 1989-02, Vol.264 (5), p.2625-2633

1989

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The therapeutic potential of agents acting via purine receptors

Expert opinion on investigational drugs, 1998-02, Vol.7 (2), p.225-243

1998

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Dihydrofolate Reductase from the Pathogenic Fungus Pneumocystis carinii: Catalytic Properties and Interaction with Antifolates

Archives of biochemistry and biophysics, 1993-09, Vol.305 (2), p.499-508

1993

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Phase I open-label, dose-escalation study of ANA773 tosylate, an oral prodrug of a toll-like receptor-7 agonist, in patients with advanced solid tumors

Journal of clinical oncology, 2011-05, Vol.29 (15_suppl), p.2524-2524

2011

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Activity of Human DNA Polymerases α and β with 2-Chloro-2′-deoxyadenosine 5′-Triphosphate as a Substrate and Quantitative Effects of Incorporation on Chain Extension

Archives of biochemistry and biophysics, 1993-04, Vol.302 (1), p.19-30

1993

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A novel inhibitor of respiratory syncytial virus isolated from ethnobotanicals

Antiviral research, 2005-12, Vol.68 (3), p.163-172

2005

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Polyethylene glycol-induced heteroassociation of malate dehydrogenase and citrate synthase

Archives of biochemistry and biophysics, 1987-10, Vol.258 (1), p.132-142

1987

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Randomised clinical trial: anti-viral activity of ANA773, an oral inducer of endogenous interferons acting via TLR7, in chronic HCV: Randomised clinical trial: anti-viral activity of ANA773 in chronic HCV

Alimentary pharmacology & therapeutics, 2011-08, Vol.34 (4), p.443-453

2011

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Kinetic Scheme for Thymidylate Synthase from Escherichia coli: Determination from Measurements of Ligand Binding, Primary and Secondary Isotope Effects, and Pre-Steady-State Catalysis

Biochemistry (Easton), 1997-04, Vol.36 (14), p.4212-4222

1997

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Role of the conserved active site residue tryptophan-24 of human dihydrofolate reductase as revealed by mutagenesis

Biochemistry (Easton), 1991-02, Vol.30 (5), p.1432-1440

1991

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Identification of ligand binding by protein stabilization: comparison of ATLAS with biophysical and enzymatic methods

Assay and drug development technologies, 2008-02, Vol.6 (1), p.69-81

2008

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Clinical Evaluation of the ZstatFlu-II Test: a Chemiluminescent Rapid Diagnostic Test for Influenza Virus

Journal of Clinical Microbiology, 2002-07, Vol.40 (7), p.2331-2334

2002

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Randomised clinical trial: anti‐viral activity of ANA773, an oral inducer of endogenous interferons acting via TLR7, in chronic HCV

The pharmacology of endosomal TLR agonists in viral disease

Methotrexate-resistant variants of human dihydrofolate reductase. Effects of Phe31 substitutions

Kinetics of the formation and isomerization of methotrexate complexes of recombinant human dihydrofolate reductase

Role of aspartate 27 in the binding of methotrexate to dihydrofolate reductase from Escherichia coli

Unusual transient- and steady-state kinetic behavior is predicted by the kinetic scheme operational for recombinant human dihydrofolate reductase

Rapid diagnostics: the detection of neuraminidase activity as a technology for high-specificity targets

AMP Deaminase Inhibitors. 2. Initial Discovery of a Non-Nucleotide Transition-State Inhibitor Series

AMP Deaminase Inhibitors. 3. SAR of 3-(Carboxyarylalkyl)coformycin Aglycon Analogues

Role of aspartate 27 of dihydrofolate reductase from Escherichia coli in interconversion of active and inactive enzyme conformers and binding of NADPH

Hydride transfer by dihydrofolate reductase. Causes and consequences of the wide range of rates exhibited by bacterial and vertebrate enzymes

Rapid kinetics of the glucose transporter from human erythrocytes. Detection and measurement of a half-turnover of the purified transporter

Insulin stimulates fluid-phase endocytosis and exocytosis in 3T3-L1 adipocytes

Atypical transient state kinetics of recombinant human dihydrofolate reductase produced by hysteretic behavior. Comparison with dihydrofolate reductases from other sources

The therapeutic potential of agents acting via purine receptors

Dihydrofolate Reductase from the Pathogenic Fungus Pneumocystis carinii: Catalytic Properties and Interaction with Antifolates

Phase I open-label, dose-escalation study of ANA773 tosylate, an oral prodrug of a toll-like receptor-7 agonist, in patients with advanced solid tumors

Activity of Human DNA Polymerases α and β with 2-Chloro-2′-deoxyadenosine 5′-Triphosphate as a Substrate and Quantitative Effects of Incorporation on Chain Extension

A novel inhibitor of respiratory syncytial virus isolated from ethnobotanicals

Polyethylene glycol-induced heteroassociation of malate dehydrogenase and citrate synthase

Randomised clinical trial: anti-viral activity of ANA773, an oral inducer of endogenous interferons acting via TLR7, in chronic HCV: Randomised clinical trial: anti-viral activity of ANA773 in chronic HCV

Kinetic Scheme for Thymidylate Synthase from Escherichia coli: Determination from Measurements of Ligand Binding, Primary and Secondary Isotope Effects, and Pre-Steady-State Catalysis

Role of the conserved active site residue tryptophan-24 of human dihydrofolate reductase as revealed by mutagenesis

Identification of ligand binding by protein stabilization: comparison of ATLAS with biophysical and enzymatic methods

Clinical Evaluation of the ZstatFlu-II Test: a Chemiluminescent Rapid Diagnostic Test for Influenza Virus

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