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Fcγ Receptor-Dependent Internalization and Off-Target Cytotoxicity of Antibody-Drug Conjugate Aggregates

Pharmaceutical research, 2022-01, Vol.39 (1), p.89-103

2022

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Clusterin in the protein corona plays a key role in the stealth effect of nanoparticles against phagocytes

Biochemical and biophysical research communications, 2016-11, Vol.480 (4), p.690-695

2016

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Characterization of anti-SARS-CoV-2 monoclonal antibodies focusing on antigen binding, neutralization, and FcγR activation via formation of immune complex

mAbs, 2023, Vol.15 (1), p.2222874-2222874

2023

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Silver Nanoparticles Induce DNA Hypomethylation through Proteasome-Mediated Degradation of DNA Methyltransferase 1

Biological and Pharmaceutical Bulletin, 2020/12/01, Vol.43(12), pp.1924-1930

2020

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Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies

mAbs, 2019-07, Vol.11 (5), p.826-836

2019

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Specific peptide conjugation to a therapeutic antibody leads to enhanced therapeutic potency and thermal stability by reduced Fc dynamics

Scientific reports, 2023-10, Vol.13 (1), p.16561-16561, Article 16561

2023

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Protein corona changes mediated by surface modification of amorphous silica nanoparticles suppress acute toxicity and activation of intrinsic coagulation cascade in mice

Nanotechnology, 2015-06, Vol.26 (24), p.245101-9

2015

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Recent Achievements and Current Interests in Research on the Characterization and Quality Control of Biopharmaceuticals in Japan

Journal of pharmaceutical sciences, 2020-05, Vol.109 (5), p.1652-1661

2020

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Target-independent Immune-cell Activation by Aggregates of T Cell-redirecting Bispecific Antibodies

Journal of pharmaceutical sciences, 2023-09, Vol.112 (9), p.2419-2426

2023

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FcγRIIIa-158V/F polymorphism affects the performance of FcγRIIIa-related bioassay

Biochemical and biophysical research communications, 2022-06, Vol.608, p.149-155

2022

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Fcγ Receptor Activation by Human Monoclonal Antibody Aggregates

Journal of pharmaceutical sciences, 2020-01, Vol.109 (1), p.576-583

2020

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Linker and Conjugation Site Synergy in Antibody–Drug Conjugates: Impacts on Biological Activity

Bioconjugate chemistry, 2024-10, Vol.35 (10), p.1568-1576

2024

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Strategic design of GalNAc-helical peptide ligands for efficient liver targeting

Chemical science (Cambridge), 2024-10

2024

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Characterization of Aggregated Antibody-Silicone Oil Complexes: From Perspectives of Morphology, 3D Image, and Fcγ Receptor Activation

Journal of pharmaceutical sciences, 2021-03, Vol.110 (3), p.1189-1196

2021

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Fc[gamma] Receptor-Dependent Internalization and Off-Target Cytotoxicity of Antibody-Drug Conjugate Aggregates

Pharmaceutical research, 2022-01, Vol.39 (1), p.89

2022

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Intracellular trafficking of particles inside endosomal vesicles is regulated by particle size

Journal of controlled release, 2017-08, Vol.260, p.183-193

2017

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Effects of amino acid substitutions on the biological activity of anti-CD20 monoclonal antibody produced by transgenic silkworms (Bombyx mori)

Biochemical and biophysical research communications, 2018-09, Vol.503 (4), p.2633-2638

2018

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Human Scavenger Receptor A1-Mediated Inflammatory Response to Silica Particle Exposure Is Size Specific

Frontiers in immunology, 2017-04, Vol.8, p.379-379

2017

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Single particle tracking method for the analysis of intracellular movement of the silica nanoparticles

Toxicology letters, 2014-09, Vol.229, p.S186-S187

2014

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Characterization of anti-SARS-CoV-2 monoclonal antibodies focusing on antigen binding, neutralization, and FcγR activation via formation of immune complex

mAbs, 2023, Vol.15 (1)

2023

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Effect of carvedilol on atrioventricular conduction in the ischemic heart

European journal of pharmacology, 2001-01, Vol.412 (2), p.145-153

2001

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Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies

mAbs, 2019, Vol.11 (5), p.826-836

2019

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MECHANISMS OF ATRIAL NATRIURETIC PEPTIDE (ANP) SECRETION BY RAT HEARTS PERFUSED IN VITRO : Ca2+-dependent Signal Transduction for ANP Release by Mechanical Stretch

JAPANESE CIRCULATION JOURNAL, 1990/10/20, Vol.54(10), pp.1283-1294

1990

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CARDIOTOXICITY STUDY OF ME2303 WITH THE INTERVAL INTRAVENOUS INJECTIONS TO RATS

The Japanese Journal of Antibiotics, 1990/07/25, Vol.43(7), pp.1230-1237

1990

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ME2303のラットへの静脈内間欠投与による心毒性試験

The Japanese Journal of Antibiotics, 1990/07/25, Vol.43(7), pp.1230-1237

1990

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Fcγ Receptor-Dependent Internalization and Off-Target Cytotoxicity of Antibody-Drug Conjugate Aggregates

Clusterin in the protein corona plays a key role in the stealth effect of nanoparticles against phagocytes

Characterization of anti-SARS-CoV-2 monoclonal antibodies focusing on antigen binding, neutralization, and FcγR activation via formation of immune complex

Silver Nanoparticles Induce DNA Hypomethylation through Proteasome-Mediated Degradation of DNA Methyltransferase 1

Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies

Specific peptide conjugation to a therapeutic antibody leads to enhanced therapeutic potency and thermal stability by reduced Fc dynamics

Protein corona changes mediated by surface modification of amorphous silica nanoparticles suppress acute toxicity and activation of intrinsic coagulation cascade in mice

Recent Achievements and Current Interests in Research on the Characterization and Quality Control of Biopharmaceuticals in Japan

Target-independent Immune-cell Activation by Aggregates of T Cell-redirecting Bispecific Antibodies

FcγRIIIa-158V/F polymorphism affects the performance of FcγRIIIa-related bioassay

Fcγ Receptor Activation by Human Monoclonal Antibody Aggregates

Linker and Conjugation Site Synergy in Antibody–Drug Conjugates: Impacts on Biological Activity

Strategic design of GalNAc-helical peptide ligands for efficient liver targeting

Characterization of Aggregated Antibody-Silicone Oil Complexes: From Perspectives of Morphology, 3D Image, and Fcγ Receptor Activation

Fc[gamma] Receptor-Dependent Internalization and Off-Target Cytotoxicity of Antibody-Drug Conjugate Aggregates

Intracellular trafficking of particles inside endosomal vesicles is regulated by particle size

Effects of amino acid substitutions on the biological activity of anti-CD20 monoclonal antibody produced by transgenic silkworms (Bombyx mori)

Human Scavenger Receptor A1-Mediated Inflammatory Response to Silica Particle Exposure Is Size Specific

Single particle tracking method for the analysis of intracellular movement of the silica nanoparticles

Characterization of anti-SARS-CoV-2 monoclonal antibodies focusing on antigen binding, neutralization, and FcγR activation via formation of immune complex

Effect of carvedilol on atrioventricular conduction in the ischemic heart

Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies

MECHANISMS OF ATRIAL NATRIURETIC PEPTIDE (ANP) SECRETION BY RAT HEARTS PERFUSED IN VITRO : Ca2+-dependent Signal Transduction for ANP Release by Mechanical Stretch

CARDIOTOXICITY STUDY OF ME2303 WITH THE INTERVAL INTRAVENOUS INJECTIONS TO RATS

ME2303のラットへの静脈内間欠投与による心毒性試験

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