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Drug metabolism and pharmacokinetic strategies for oligonucleotide- and mRNA-based drug development

Drug discovery today, 2018-10, Vol.23 (10), p.1733-1745

2018

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Structure−Brain Exposure Relationships in Rat and Human Using a Novel Data Set of Unbound Drug Concentrations in Brain Interstitial and Cerebrospinal Fluids

Journal of medicinal chemistry, 2009-10, Vol.52 (20), p.6233-6243

2009

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In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

Drug metabolism and disposition, 2007-09, Vol.35 (9), p.1711

2007

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Development of a high-throughput brain slice method for studying drug distribution in the central nervous system

Drug metabolism and disposition, 2009-06, Vol.37 (6), p.1226

2009

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Effects of a novel potent melanin‐concentrating hormone receptor 1 antagonist, AZD1979, on body weight homeostasis in mice and dogs

British journal of pharmacology, 2016-09, Vol.173 (18), p.2739-2751

2016

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Hepatic patatin‐like phospholipase domain‐containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans

Hepatology communications, 2022-10, Vol.6 (10), p.2689-2701

2022

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Plasma Pharmacokinetics of N-Acetylgalactosamine-Conjugated Small-Interfering Ribonucleic Acids (GalNAc-Conjugated siRNAs)

Clinical pharmacokinetics, 2023-12, Vol.62 (12), p.1661-1672

2023

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Corrigendum to ‘Drug metabolism and pharmacokinetic strategies for oligonucleotide- and mRNA-based drug development’ Drug Discovery Today 23 (2018) 1733–1745

Drug discovery today, 2019-09, Vol.24 (9), p.1953-1953

2019

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Integrating efficacy and safety: Telemetry and echocardiography in a pig model of myocardial infarction

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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Identification of positron emission tomography (PET) tracer candidates by prediction of the target-bound fraction in the brain

EJNMMI research, 2014-09, Vol.4 (1), p.50-50, Article 50

2014

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Evaluating the safety pharmacology of a novel modified mRNA therapeutic for patients with ischaemic vascular disease

Journal of pharmacological and toxicological methods, 2018-09, Vol.93, p.151-151

2018

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In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms

Journal of molecular graphics & modelling, 2011-08, Vol.29 (8), p.985-995

2011

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Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes

Drug metabolism and disposition, 2000-08, Vol.28 (8), p.966

2000

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Discovery of Agonists of Cannabinoid Receptor 1 with Restricted Central Nervous System Penetration Aimed for Treatment of Gastroesophageal Reflux Disease

Journal of medicinal chemistry, 2013-01, Vol.56 (1), p.220-240

2013

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A modeling approach for compounds affecting body composition

Journal of pharmacokinetics and pharmacodynamics, 2013-12, Vol.40 (6), p.651-667

2013

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Activation of the GABAB receptor inhibits Transient lower esophageal sphincter relaxations in dogs

Gastroenterology (New York, N.Y. 1943), 1999-11, Vol.117 (5), p.1147-1154

1999

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Pharmacokinetics (PK) and effect on pentagastrin stimulated peak acid output (PAO) of omeprazole (O) and its 2 optical isomers, S-omeprazole/esomeprazole (E) and R-omeprazole (R-O)

Gastroenterology (New York, N.Y. 1943), 2000-04, Vol.118 (4), p.A1210-A1210

2000

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Activation of the GABA B receptor inhibits transient lower esophageal sphincter relaxations in dogs

Gastroenterology (New York, N.Y. 1943), 1999, Vol.117 (5), p.1147-1154

1999

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Drug metabolism and pharmacokinetic strategies for oligonucleotide- and mRNA-based drug development

Structure−Brain Exposure Relationships in Rat and Human Using a Novel Data Set of Unbound Drug Concentrations in Brain Interstitial and Cerebrospinal Fluids

In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

Development of a high-throughput brain slice method for studying drug distribution in the central nervous system

Effects of a novel potent melanin‐concentrating hormone receptor 1 antagonist, AZD1979, on body weight homeostasis in mice and dogs

Hepatic patatin‐like phospholipase domain‐containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans

Plasma Pharmacokinetics of N-Acetylgalactosamine-Conjugated Small-Interfering Ribonucleic Acids (GalNAc-Conjugated siRNAs)

Corrigendum to ‘Drug metabolism and pharmacokinetic strategies for oligonucleotide- and mRNA-based drug development’ Drug Discovery Today 23 (2018) 1733–1745

Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties

Integrating efficacy and safety: Telemetry and echocardiography in a pig model of myocardial infarction

Identification of positron emission tomography (PET) tracer candidates by prediction of the target-bound fraction in the brain

Evaluating the safety pharmacology of a novel modified mRNA therapeutic for patients with ischaemic vascular disease

In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms

Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes

Discovery of Agonists of Cannabinoid Receptor 1 with Restricted Central Nervous System Penetration Aimed for Treatment of Gastroesophageal Reflux Disease

A modeling approach for compounds affecting body composition

Activation of the GABAB receptor inhibits Transient lower esophageal sphincter relaxations in dogs

Pharmacokinetics (PK) and effect on pentagastrin stimulated peak acid output (PAO) of omeprazole (O) and its 2 optical isomers, S-omeprazole/esomeprazole (E) and R-omeprazole (R-O)

Activation of the GABA B receptor inhibits transient lower esophageal sphincter relaxations in dogs

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