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MCC950 closes the active conformation of NLRP3 to an inactive state

Nature chemical biology, 2019-06, Vol.15 (6), p.560-564

2019

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Cell Volume Regulation Modulates NLRP3 Inflammasome Activation

Immunity (Cambridge, Mass.), 2012-09, Vol.37 (3), p.487-500

2012

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Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins

Nature communications, 2016-07, Vol.7 (1), p.12077-12077, Article 12077

2016

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NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway

Nature communications, 2018-12, Vol.9 (1), p.5182-18, Article 5182

2018

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P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis

Nature communications, 2019-06, Vol.10 (1), p.2711-14, Article 2711

2019

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RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly

Cell reports (Cambridge), 2020-11, Vol.33 (7), p.108405-108405, Article 108405

2020

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Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality

BMC biology, 2022-01, Vol.20 (1), p.9-9, Article 9

2022

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Techniques to Study Inflammasome Activation and Inhibition by Small Molecules

Molecules (Basel, Switzerland), 2021-03, Vol.26 (6), p.1704

2021

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Soluble P2X7 Receptor Is Elevated in the Plasma of COVID-19 Patients and Correlates With Disease Severity

Frontiers in immunology, 2022-05, Vol.13, p.894470-894470

2022

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NLRP3 Inflammasome and Pyroptosis in Liver Pathophysiology: The Emerging Relevance of Nrf2 Inducers

Antioxidants, 2022-04, Vol.11 (5), p.870

2022

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Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles

Communications biology, 2022-06, Vol.5 (1), p.524-524, Article 524

2022

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Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

Nature communications, 2024-02, Vol.15 (1), p.1096-1096, Article 1096

2024

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Addendum: MCC950 closes the active conformation of NLRP3 to an inactive state

Nature chemical biology, 2021-03, Vol.17 (3), p.361-361

2021

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Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease

Journal of medicinal chemistry, 2017-05, Vol.60 (9), p.3656-3671

2017

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Evolution of the gasdermin family and pyroptosis

Developmental and comparative immunology, 2023-12, Vol.149, p.105060-105060, Article 105060

2023

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Aluminum is a powerful adjuvant in teleost fish despite failing to induce interleukin-1ß release

Developmental and comparative immunology, 2018-08, Vol.85, p.18

2018

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Aluminum is a powerful adjuvant in teleost fish despite failing to induce interleukin-1β release

Developmental and comparative immunology, 2018-08, Vol.85, p.18-24

2018

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Evolution of inflammasome functions in vertebrates: Inflammasome and caspase-1 trigger fish macrophage cell death but are dispensable for the processing of IL-1β

Innate immunity (London, England), 2012-12, Vol.18 (6), p.815-824

2012

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The zebrafish as a model to study the inflammasome

Inflammasome, 2014-01, Vol.1 (1)

2014

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Measuring NLR Oligomerization III: Detection of NLRP3 and NLRC4 Complex by Bioluminescence Resonance Energy Transfer

Methods in molecular biology (Clifton, N.J.), 2023, Vol.2696, p.93

2023

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Amniotic membrane stimulates cell migration by modulating transforming growth factor‐β signalling

Journal of tissue engineering and regenerative medicine, 2018-03, Vol.12 (3), p.808-820

2018

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A non-canonical function of telomerase RNA in the regulation of developmental myelopoiesis in zebrafish

Nature communications, 2014-02, Vol.5 (1), p.3228-3228, Article 3228

2014

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Response to Boyle et al

Immunity (Cambridge, Mass.), 2013-03, Vol.38 (3), p.400-401

2013

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Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation

Science advances, 2021-09, Vol.7 (38), p.eabf4468-eabf4468

2021

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TLR agonists extend the functional lifespan of professional phagocytic granulocytes in the bony fish gilthead seabream and direct precursor differentiation towards the production of granulocytes

Molecular immunology, 2011-03, Vol.48 (6-7), p.846-859

2011

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MCC950 closes the active conformation of NLRP3 to an inactive state

Cell Volume Regulation Modulates NLRP3 Inflammasome Activation

Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins

NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway

P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis

RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly

Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality

Techniques to Study Inflammasome Activation and Inhibition by Small Molecules

Soluble P2X7 Receptor Is Elevated in the Plasma of COVID-19 Patients and Correlates With Disease Severity

NLRP3 Inflammasome and Pyroptosis in Liver Pathophysiology: The Emerging Relevance of Nrf2 Inducers

Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles

Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

Addendum: MCC950 closes the active conformation of NLRP3 to an inactive state

Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease

Evolution of the gasdermin family and pyroptosis

Aluminum is a powerful adjuvant in teleost fish despite failing to induce interleukin-1ß release

Aluminum is a powerful adjuvant in teleost fish despite failing to induce interleukin-1β release

Evolution of inflammasome functions in vertebrates: Inflammasome and caspase-1 trigger fish macrophage cell death but are dispensable for the processing of IL-1β

The zebrafish as a model to study the inflammasome

Measuring NLR Oligomerization III: Detection of NLRP3 and NLRC4 Complex by Bioluminescence Resonance Energy Transfer

Amniotic membrane stimulates cell migration by modulating transforming growth factor‐β signalling

A non-canonical function of telomerase RNA in the regulation of developmental myelopoiesis in zebrafish

Response to Boyle et al

Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation

TLR agonists extend the functional lifespan of professional phagocytic granulocytes in the bony fish gilthead seabream and direct precursor differentiation towards the production of granulocytes

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