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R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies

British journal of cancer, 2007-11, Vol.97 (10), p.1344-1353

2007

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356 Discovery of novel pyrido[2,3-b]pyrazine as fibroblast growth factor receptor (FGFR-1, 2, 3 & 4) kinase inhibitors with nanomolar affinity

European journal of cancer (1990), 2014-11, Vol.50, p.115-115

2014

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400 Optimization of novel pyrido[2,3-b]pyrazine based small molecule fibroblast growth factor receptor 1, 2, 3 & 4 (FGFR) inhibitors into a potential clinical candidate

European journal of cancer (1990), 2014-11, Vol.50, p.128-128

2014

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Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro

Cancer research (Chicago, Ill.), 2001, Vol.61 (1), p.131-137

2001

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On the use of boronates in the Petasis reaction

Tetrahedron letters, 2005-11, Vol.46 (46), p.8027-8031

2005

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Farnesyl protein transferase inhibitor ZARNESTRA R115777 - history of a discovery

Current topics in medicinal chemistry, 2003-01, Vol.3 (10), p.1095

2003

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Abstract 1361: Fragment based drug discovery of selective inhibitors of Fibroblast Growth Factor Receptor (FGFR)

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.1361-1361

2011

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New Chiral Brominating and Chlorinating Agents

Synthetic communications, 1993-09, Vol.23 (17), p.2423-2433

1993

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Abstract 5778: Fragment-based drug discovery of selective inhibitors of fibroblast growth factor receptor (FGFr)

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.5778-5778

2010

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Asymmetric Synthesis of 2-chloro- and 2-bromo-alkanoic acids by halogenation of α-D-glucofuranose-derived silyl ketene acetals

Tetrahedron: asymmetry, 1995, Vol.6 (8), p.1919-1932

1995

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5-Imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors

Bioorganic & medicinal chemistry letters, 2003-05, Vol.13 (9), p.1543-1547

2003

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Asymmetric Synthesis of (S)-2-Chloroalkanoic Acids with High Enantiomeric Excess by Diastereoselective Halogenation of α-D-Glucofuranose-Derived Silyl Ketene Acetals

Synlett, 1991, Vol.1991 (11), p.807-808

1991

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Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors

European journal of medicinal chemistry, 2005-06, Vol.40 (6), p.597-606

2005

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Substituted azoloquinolines and -quinazolines as new potent Farnesyl Protein Transferase inhibitors

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (24), p.4365-4369

2003

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An Easy Access to (3R,4R)-O,O-Diacyltartrimides

Synthetic communications, 1992-03, Vol.22 (5), p.735-740

1992

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Glass-forming tendency and stability of the amorphous state in the aqueous solutions of linear polyalcohols with four carbons: I. Binary systems water-polyalcohol

Cryobiology, 1986, Vol.23 (5), p.453-469

1986

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4-Methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (24), p.4361-4364

2003

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125 Synthesis, biological evaluation and structure activity relationships of a novel servies of aromatic hydroxamic acids as potent HDAC inhibitors

European journal of cancer supplements, 2004-09, Vol.2 (8), p.40-41

2004

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Farnesyl Protein Transferase Inhibitors: Medicinal Chemistry, Molecular Mechanisms, and Progress in the Clinic

Cancer, 2006, p.133-168

2006

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Glass-forming tendency and stability of the amorphous state in the aqueous solutions of linear polyalcohols with four carbons

Cryobiology, 1986-10, Vol.23 (5), p.453-469

1986

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Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor

Molecular cancer therapeutics, 2017-06, Vol.16 (6), p.1010-1020

2017

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ChemInform Abstract: An Easy Access to (3R,4R)-O,O-Diacyltartrimides

ChemInform, 1992-08, Vol.23 (32), p.no-no

1992

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ChemInform Abstract: New Chiral Brominating and Chlorinating Agents, e.g. (II), (IV)

ChemInform, 1994-10, Vol.25 (40), p.no-no

1994

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ChemInform Abstract: Asymmetric Synthesis of (S)-2-Chloroalkanoic Acids (S)-(V) with High Enantiomeric Excess by Diastereoselective Halogenation of α-D- Glucofuranose-Derived Silyl Ketene Acetals (III)

ChemInform, 1992-05, Vol.23 (20), p.no-no

1992

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ChemInform Abstract: Asymmetric Synthesis of 2-Chloro- and 2-Bromoalkanoic Acids by Halogenation of α-D-Glucofuranose-Derived Silyl Ketene Acetals

ChemInform, 1996-01, Vol.27 (1), p.no-no

1996

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R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies

356 Discovery of novel pyrido[2,3-b]pyrazine as fibroblast growth factor receptor (FGFR-1, 2, 3 & 4) kinase inhibitors with nanomolar affinity

400 Optimization of novel pyrido[2,3-b]pyrazine based small molecule fibroblast growth factor receptor 1, 2, 3 & 4 (FGFR) inhibitors into a potential clinical candidate

Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro

On the use of boronates in the Petasis reaction

Farnesyl protein transferase inhibitor ZARNESTRA R115777 - history of a discovery

Abstract 1361: Fragment based drug discovery of selective inhibitors of Fibroblast Growth Factor Receptor (FGFR)

New Chiral Brominating and Chlorinating Agents

Abstract 5778: Fragment-based drug discovery of selective inhibitors of fibroblast growth factor receptor (FGFr)

Asymmetric Synthesis of 2-chloro- and 2-bromo-alkanoic acids by halogenation of α-D-glucofuranose-derived silyl ketene acetals

5-Imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors

Asymmetric Synthesis of (S)-2-Chloroalkanoic Acids with High Enantiomeric Excess by Diastereoselective Halogenation of α-D-Glucofuranose-Derived Silyl Ketene Acetals

Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors

Substituted azoloquinolines and -quinazolines as new potent Farnesyl Protein Transferase inhibitors

An Easy Access to (3R,4R)-O,O-Diacyltartrimides

Glass-forming tendency and stability of the amorphous state in the aqueous solutions of linear polyalcohols with four carbons: I. Binary systems water-polyalcohol

4-Methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA

125 Synthesis, biological evaluation and structure activity relationships of a novel servies of aromatic hydroxamic acids as potent HDAC inhibitors

Farnesyl Protein Transferase Inhibitors: Medicinal Chemistry, Molecular Mechanisms, and Progress in the Clinic

Glass-forming tendency and stability of the amorphous state in the aqueous solutions of linear polyalcohols with four carbons

Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor

ChemInform Abstract: An Easy Access to (3R,4R)-O,O-Diacyltartrimides

ChemInform Abstract: New Chiral Brominating and Chlorinating Agents, e.g. (II), (IV)

ChemInform Abstract: Asymmetric Synthesis of (S)-2-Chloroalkanoic Acids (S)-(V) with High Enantiomeric Excess by Diastereoselective Halogenation of α-D- Glucofuranose-Derived Silyl Ketene Acetals (III)

ChemInform Abstract: Asymmetric Synthesis of 2-Chloro- and 2-Bromoalkanoic Acids by Halogenation of α-D-Glucofuranose-Derived Silyl Ketene Acetals

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