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Pharmacological approaches to restore mitochondrial function

Nature reviews. Drug discovery, 2013-06, Vol.12 (6), p.465-483

2013

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The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

Cell metabolism, 2012-06, Vol.15 (6), p.838-847

2012

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Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits

Cell, 2012-09, Vol.150 (6), p.1287-1299

2012

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Bioavailable copper modulates oxidative phosphorylation and growth of tumors

Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (48), p.19507-19512

2013

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Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis

Aging cell, 2022-08, Vol.21 (8), p.e13662-n/a

2022

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Safety assessment of Urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid

Food and chemical toxicology, 2017-10, Vol.108 (Pt A), p.289-297

2017

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An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement

PLoS genetics, 2014-09, Vol.10 (9), p.e1004673

2014

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Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits

PloS one, 2012-06, Vol.7 (6), p.e39191-e39191

2012

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Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Trends in molecular medicine, 2021-07, Vol.27 (7), p.687-699

2021

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Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Nature medicine, 2016-08, Vol.22 (8), p.879-888

2016

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Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly

Scientific reports, 2018-06, Vol.8 (1), p.8548-12, Article 8548

2018

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A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans

Scientific reports, 2014-06, Vol.4 (1), p.5285, Article 5285

2014

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Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

Science translational medicine, 2021-04, Vol.13 (588)

2021

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The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

Nature metabolism, 2019-06, Vol.1 (6), p.595-603

2019

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The metabolic footprint of aging in mice

Scientific reports, 2011-10, Vol.1 (1), p.134-134, Article 134

2011

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Autophagy defect is associated with low glucose-induced apoptosis in 661W photoreceptor cells

PloS one, 2013-09, Vol.8 (9), p.e74162-e74162

2013

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Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population

European journal of clinical nutrition, 2022-02, Vol.76 (2), p.297-308

2022

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Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

Immunity (Cambridge, Mass.), 2022-11, Vol.55 (11), p.2059-2073.e8

2022

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Publisher Correction: Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly

Scientific reports, 2019-11, Vol.9 (1), p.17821-1, Article 17821

2019

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Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

Cell reports. Medicine, 2022-05, Vol.3 (5), p.100633-100633, Article 100633

2022

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An Evolutionarily Conserved Role for the Aryl Hydrocarbon Receptor in the Regulation of Movement: e1004673

PLoS genetics, 2014-09, Vol.10 (9)

2014

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An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism

Molecular metabolism (Germany), 2017-11, Vol.6 (11), p.1429-1442

2017

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MicroRNA‐382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells

Journal of cellular physiology, 2019-05, Vol.234 (5), p.6601-6610

2019

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Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis

Human molecular genetics, 2014-09, Vol.23 (18), p.4995-5008

2014

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Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

Scientific reports, 2012-05, Vol.2 (1), p.425-425, Article 425

2012

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Pharmacological approaches to restore mitochondrial function

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits

Bioavailable copper modulates oxidative phosphorylation and growth of tumors

Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis

Safety assessment of Urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid

An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement

Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

The metabolic footprint of aging in mice

Autophagy defect is associated with low glucose-induced apoptosis in 661W photoreceptor cells

Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population

Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

Publisher Correction: Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly

Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

An Evolutionarily Conserved Role for the Aryl Hydrocarbon Receptor in the Regulation of Movement: e1004673

An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism

MicroRNA‐382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

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