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Crystal Structure of the Michaelis Complex between Tissue-type Plasminogen Activator and Plasminogen Activators Inhibitor-1

The Journal of biological chemistry, 2015-10, Vol.290 (43), p.25795-25804

2015

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Origin and diversification of the plasminogen activation system among chordates

BMC ecology and evolution, 2019-01, Vol.19 (1), p.27

2019

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A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility

PloS one, 2014-12, Vol.9 (12), p.e115872

2014

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Multi-tissue RNA-seq and transcriptome characterisation of the spiny dogfish shark (Squalus acanthias) provides a molecular tool for biological research and reveals new genes involved in osmoregulation

PloS one, 2017-08, Vol.12 (8), p.e0182756-e0182756

2017

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Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator

Scientific reports, 2017-06, Vol.7 (1), p.3385-11, Article 3385

2017

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Expected and unexpected features of protein-binding RNA aptamers

Wiley interdisciplinary reviews. RNA, 2016-11, Vol.7 (6), p.744-757

2016

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The solution structure of the MANEC-type domain from hepatocyte growth factor activator inhibitor-1 reveals an unexpected PAN/apple domain-type fold

Biochemical journal, 2015-03, Vol.466 (2), p.299-309

2015

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Ligand binding modulates the structural dynamics and activity of urokinase-type plasminogen activator: A possible mechanism of plasminogen activation

PloS one, 2018-02, Vol.13 (2), p.e0192661

2018

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Structural Basis for Recognition of Urokinase-type Plasminogen Activator by Plasminogen Activator Inhibitor-1

The Journal of biological chemistry, 2011-03, Vol.286 (9), p.7027-7032

2011

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Rezymogenation of active urokinase induced by an inhibitory antibody

Biochemical journal, 2013-01, Vol.449 (1), p.161-166

2013

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Protein-binding RNA aptamers affect molecular interactions distantly from their binding sites

PloS one, 2015-03, Vol.10 (3), p.e0119207

2015

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An RNA Aptamer Inhibits a Mutation-Induced Inactivating Misfolding of a Serpin

Cell chemical biology, 2016-06, Vol.23 (6), p.700-708

2016

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Activation of Pro-uPA Is Critical for Initial Escape from the Primary Tumor and Hematogenous Dissemination of Human Carcinoma Cells

Neoplasia (New York, N.Y.), 2011-09, Vol.13 (9), p.806-IN7

2011

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Structural basis of specificity of a peptidyl urokinase inhibitor, upain-1

Journal of structural biology, 2007-10, Vol.160 (1), p.1-10

2007

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Plasminogen Activator Inhibitor-1 Is an Inhibitor of Factor VII-activating Protease in Patients with Acute Respiratory Distress Syndrome

The Journal of biological chemistry, 2007-07, Vol.282 (30), p.21671-21682

2007

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The Binding Mechanism of a Peptidic Cyclic Serine Protease Inhibitor

Journal of molecular biology, 2011-09, Vol.412 (2), p.235-250

2011

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Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides

Journal of medicinal chemistry, 2019-02, Vol.62 (4), p.2172-2183

2019

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A cyclic peptidylic inhibitor of murine urokinase-type plasminogen activator: changing species specificity by substitution of a single residue

Biochemical journal, 2008-06, Vol.412 (3), p.447-457

2008

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Characterisation of aptamer-target interactions by branched selection and high-throughput sequencing of SELEX pools

Nucleic acids research, 2015-12, Vol.43 (21), p.e139

2015

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Structural Principles in the Development of Cyclic Peptidic Enzyme Inhibitors

International journal of biological sciences, 2017-01, Vol.13 (10), p.1222-1233

2017

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Characterization of a Site on PAI-1 That Binds to Vitronectin Outside of the Somatomedin B Domain

The Journal of biological chemistry, 2008-10, Vol.283 (42), p.28487-28496

2008

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Targeting the autolysis loop of urokinase-type plasminogen activator with conformation-specific monoclonal antibodies

Biochemical journal, 2011-08, Vol.438 (1), p.39-51

2011

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Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217

FEBS letters, 2018-08, Vol.592 (15), p.2658-2667

2018

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A Urokinase-type Plasminogen Activator-inhibiting Cyclic Peptide with an Unusual P2 Residue and an Extended Protease Binding Surface Demonstrates New Modalities for Enzyme Inhibition

The Journal of biological chemistry, 2005-11, Vol.280 (46), p.38424-38437

2005

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PAI-1 - a potential therapeutic target in cancer

Current drug targets, 2007-09, Vol.8 (9), p.1030

Andreasen, Peter A

2007

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Crystal Structure of the Michaelis Complex between Tissue-type Plasminogen Activator and Plasminogen Activators Inhibitor-1

Origin and diversification of the plasminogen activation system among chordates

A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility

Multi-tissue RNA-seq and transcriptome characterisation of the spiny dogfish shark (Squalus acanthias) provides a molecular tool for biological research and reveals new genes involved in osmoregulation

Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator

Expected and unexpected features of protein-binding RNA aptamers

The solution structure of the MANEC-type domain from hepatocyte growth factor activator inhibitor-1 reveals an unexpected PAN/apple domain-type fold

Ligand binding modulates the structural dynamics and activity of urokinase-type plasminogen activator: A possible mechanism of plasminogen activation

Structural Basis for Recognition of Urokinase-type Plasminogen Activator by Plasminogen Activator Inhibitor-1

Rezymogenation of active urokinase induced by an inhibitory antibody

Protein-binding RNA aptamers affect molecular interactions distantly from their binding sites

An RNA Aptamer Inhibits a Mutation-Induced Inactivating Misfolding of a Serpin

Activation of Pro-uPA Is Critical for Initial Escape from the Primary Tumor and Hematogenous Dissemination of Human Carcinoma Cells

Structural basis of specificity of a peptidyl urokinase inhibitor, upain-1

Plasminogen Activator Inhibitor-1 Is an Inhibitor of Factor VII-activating Protease in Patients with Acute Respiratory Distress Syndrome

The Binding Mechanism of a Peptidic Cyclic Serine Protease Inhibitor

Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides

A cyclic peptidylic inhibitor of murine urokinase-type plasminogen activator: changing species specificity by substitution of a single residue

Characterisation of aptamer-target interactions by branched selection and high-throughput sequencing of SELEX pools

Structural Principles in the Development of Cyclic Peptidic Enzyme Inhibitors

Characterization of a Site on PAI-1 That Binds to Vitronectin Outside of the Somatomedin B Domain

Targeting the autolysis loop of urokinase-type plasminogen activator with conformation-specific monoclonal antibodies

Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217

A Urokinase-type Plasminogen Activator-inhibiting Cyclic Peptide with an Unusual P2 Residue and an Extended Protease Binding Surface Demonstrates New Modalities for Enzyme Inhibition

PAI-1 - a potential therapeutic target in cancer

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