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Impact of a five-dimensional framework on R&D productivity at AstraZeneca

Nature reviews. Drug discovery, 2018-03, Vol.17 (3), p.167-181

2018

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Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.7025-7048

2013

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Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors

Toxicologic pathology, 2011-10, Vol.39 (6), p.916-924

2011

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Pharmacokinetics and Tissue Disposition of Indole-3-carbinol and Its Acid Condensation Products after Oral Administration to Mice

Clinical cancer research, 2004-08, Vol.10 (15), p.5233-5241

2004

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De novo LINE-1 retrotransposition in HepG2 cells preferentially targets gene poor regions of chromosome 13

Genomics (San Diego, Calif.), 2014-08, Vol.104 (2), p.96-104

2014

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Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC)

Journal of medicinal chemistry, 2019-12, Vol.62 (24), p.11004-11018

2019

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Liquid chromatographic assay for the simultaneous determination of indole-3-carbinol and its acid condensation products in plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003-04, Vol.787 (2), p.281-291

2003

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Reprogramming of the HepG2 genome by long interspersed nuclear element-1

Molecular oncology, 2013-08, Vol.7 (4), p.812-825

2013

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Physiological modeling of formulated and crystalline 3,3'-diindolylmethane pharmacokinetics following oral administration in mice

Drug metabolism and disposition, 2004-06, Vol.32 (6), p.632

2004

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Valvular heart lesions in Han Wistar rats dosed with ALK5 inhibitors

Toxicology (Amsterdam), 2010, Vol.278 (3), p.343-343

2010

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Use of chemical enantiomers to further characterise the pre-clinical safety profile of MCL-1 inhibitors

Toxicology letters, 2017-10, Vol.280, p.S168-S168

2017

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Abstract 1647: Discovery of AZD0364, a potent and selective oral inhibitor of ERK1/2 that is efficacious in both monotherapy and combination therapy in models of NSCLC

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1647-1647

2018

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Abstract 3676: Influence of early toxicology assessment on the selection of azd9291

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.3676-3676

2014

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Suppression of rhenium and osmium production in tungsten by selective isotopic enrichment

Fusion engineering and design, 2023-12, Vol.197, p.114073, Article 114073

2023

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Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor

Journal of medicinal chemistry, 2014-10, Vol.57 (20), p.8249-8267

2014

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Atomistic simulations for investigation of substrate effects on lipid in-source fragmentation in secondary ion mass spectrometry

Biointerphases, 2023-01, Vol.18 (1), p.011003-011003

2023

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A Mineral-Doped Micromodel Platform Demonstrates Fungal Bridging of Carbon Hot Spots and Hyphal Transport of Mineral-Derived Nutrients

mSystems, 2022-12, Vol.7 (6), p.e0091322-e0091322

2022

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Sequential Ammonia and Carbon Dioxide Adsorption on Pyrolyzed Biomass to Recover Waste Stream Nutrients

ACS sustainable chemistry & engineering, 2020-05, Vol.8 (18), p.7121-7131

2020

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Abstract P2-13-23: Activity and tolerability of combination of trastuzumab deruxtecan with the pan-AKT inhibitor capivasertib in preclinical HER2+ and HER2-low breast cancer models

Cancer research (Chicago, Ill.), 2022-02, Vol.82 (4_Supplement), p.P2-P2-13-23

2022

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Correlating Bridging Ligand with Properties of Ligand-Templated [MnII 3X3]3+ Clusters (X = Br–, Cl–, H–, MeO–)

Inorganic chemistry, 2017-10, Vol.56 (19), p.12012-12022

2017

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Abstract P2-13-18: Activity and tolerability of combination of trastuzumab deruxtecan with olaparib in preclinical HER2+ and HER2-low breast cancer models

Cancer research (Chicago, Ill.), 2022-02, Vol.82 (4_Supplement), p.P2-P2-13-18

2022

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Correction to “Discovery of a Thiadiazole–Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models”

Journal of medicinal chemistry, 2023-07, Vol.66 (13), p.9223-9224

2023

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Impact of a five-dimensional framework on R&D productivity at AstraZeneca

Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)

Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors

Pharmacokinetics and Tissue Disposition of Indole-3-carbinol and Its Acid Condensation Products after Oral Administration to Mice

De novo LINE-1 retrotransposition in HepG2 cells preferentially targets gene poor regions of chromosome 13

Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC)

Liquid chromatographic assay for the simultaneous determination of indole-3-carbinol and its acid condensation products in plasma

Reprogramming of the HepG2 genome by long interspersed nuclear element-1

Physiological modeling of formulated and crystalline 3,3'-diindolylmethane pharmacokinetics following oral administration in mice

Valvular heart lesions in Han Wistar rats dosed with ALK5 inhibitors

Use of chemical enantiomers to further characterise the pre-clinical safety profile of MCL-1 inhibitors

Abstract 1647: Discovery of AZD0364, a potent and selective oral inhibitor of ERK1/2 that is efficacious in both monotherapy and combination therapy in models of NSCLC

Abstract 3676: Influence of early toxicology assessment on the selection of azd9291

Suppression of rhenium and osmium production in tungsten by selective isotopic enrichment

Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor

Atomistic simulations for investigation of substrate effects on lipid in-source fragmentation in secondary ion mass spectrometry

A Mineral-Doped Micromodel Platform Demonstrates Fungal Bridging of Carbon Hot Spots and Hyphal Transport of Mineral-Derived Nutrients

Sequential Ammonia and Carbon Dioxide Adsorption on Pyrolyzed Biomass to Recover Waste Stream Nutrients

Abstract P2-13-23: Activity and tolerability of combination of trastuzumab deruxtecan with the pan-AKT inhibitor capivasertib in preclinical HER2+ and HER2-low breast cancer models

Prostaglandin E 2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells

Correlating Bridging Ligand with Properties of Ligand-Templated [MnII 3X3]3+ Clusters (X = Br–, Cl–, H–, MeO–)

Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305

Abstract P2-13-18: Activity and tolerability of combination of trastuzumab deruxtecan with olaparib in preclinical HER2+ and HER2-low breast cancer models

Correction to “Discovery of a Thiadiazole–Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models”

Discovery of a Thiadiazole–Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models

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