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Novel Dual-Target Kinase Inhibitors of EGFR and ALK Were Designed, Synthesized, and Induced Cell Apoptosis in Non-Small Cell Lung Cancer

Molecules (Basel, Switzerland), 2023-02, Vol.28 (5), p.2006

2023

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A novel c-Met/TRK inhibitor 1D228 efficiently inhibits tumor growth by targeting angiogenesis and tumor cell proliferation

Cell death & disease, 2023-11, Vol.14 (11), p.728-728, Article 728

2023

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Synthesis and evaluation of selenium-containing indole chalcone and diarylketone derivatives as tubulin polymerization inhibition agents

Organic & biomolecular chemistry, 2017, Vol.15 (35), p.7404-7410

2017

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Synthesis and evaluation of new 2-chloro-4-aminopyrimidine and 2,6-dimethyl-4-aminopyrimidine derivatives as tubulin polymerization inhibitors

Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (10), p.1769-1775

2018

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Glucagon Enhances Chemotherapy Efficacy By Inhibition of Tumor Vessels in Colorectal Cancer

Advanced science, 2024-02, Vol.11 (6), p.e2307271-n/a

2024

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Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents

Journal of medicinal chemistry, 2017-09, Vol.60 (17), p.7300-7314

2017

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Design, synthesis, and biological evaluation of cyclic-indole derivatives as anti-tumor agents via the inhibition of tubulin polymerization

European journal of medicinal chemistry, 2017-01, Vol.125, p.663-675

2017

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Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease

European journal of medicinal chemistry, 2019-02, Vol.163, p.512-526

2019

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Design, synthesis, and biological evaluation of novel benzodiazepine derivatives as anticancer agents through inhibition of tubulin polymerization in vitro and in vivo

European journal of medicinal chemistry, 2019-11, Vol.182, p.111670-111670, Article 111670

2019

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Evaluation of 4-phenylamino-substituted naphthalene-1,2-diones as tubulin polymerization inhibitors

Bioorganic & medicinal chemistry letters, 2018-10, Vol.28 (18), p.3057-3063

2018

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Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFRL858R/T790M inhibitors

European journal of medicinal chemistry, 2021-02, Vol.212, p.113019, Article 113019

2021

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A Multifunctional Vanadium-Iron-Oxide Nanoparticle Eradicates Hepatocellular Carcinoma via Targeting Tumor and Endothelial Cells

ACS applied materials & interfaces, 2022-06, Vol.14 (25), p.28514-28526

2022

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Synthesis, in vitro and in vivo evaluation of new hybrids of millepachine and phenstatin as potent tubulin polymerization inhibitors

Organic & biomolecular chemistry, 2017-01, Vol.15 (4), p.852-862

2017

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Design, synthesis, and biological evaluation of histone deacetylase inhibitors possessing glutathione peroxidase-like and antioxidant activities against Alzheimer’s disease

Bioorganic & medicinal chemistry, 2018-11, Vol.26 (21), p.5718-5729

2018

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The synthesis and evaluation of new butadiene derivatives as tubulin polymerization inhibitors

Bioorganic & medicinal chemistry, 2017-06, Vol.25 (12), p.3059-3067

2017

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Inhibition of TGF-β1/Smad3 signaling by compound 5aa: A potential treatment for idiopathic pulmonary fibrosis

Bioorganic chemistry, 2024-06, Vol.147, p.107374-107374, Article 107374

2024

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Synthesis and Biological Evaluation of Selenium-Containing 4‑Anilinoquinazoline Derivatives as Novel Antimitotic Agents

Journal of medicinal chemistry, 2018-03, Vol.61 (6), p.2571-2588

2018

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Synthesis and evaluation of new pirfenidone derivatives as anti-fibrosis agents

RSC advances, 2022-05, Vol.12 (23), p.14492-1451

2022

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Novel third-generation pyrimidines-based EGFR tyrosine kinase inhibitors targeting EGFR T790M mutation in advanced non-small cell lung cancer

Bioorganic chemistry, 2022-05, Vol.122, p.105743-105743, Article 105743

2022

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The discovery of a potent and selective third-generation EGFR kinase inhibitor as a therapy for EGFR L858R/T790M double mutant non-small cell lung cancer

European journal of medicinal chemistry, 2019-12, Vol.183, p.111709, Article 111709

2019

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The new N2, N4-diphenylpyridine-2,4-diamine deuterated derivatives as EGFR inhibitors to overcome C797S-mediated resistance

Bioorganic chemistry, 2024-05, Vol.146, p.107313-107313, Article 107313

2024

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Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing a sulfoxide moiety as anaplastic lymphoma kinase (ALK) inhibition agents

Bioorganic & medicinal chemistry letters, 2021-09, Vol.48, p.128253-128253, Article 128253

2021

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Synthesis, in vitro and in vivo evaluation of new hybrids of millepachine and phenstatin as potent tubulin polymerization inhibitorsElectronic supplementary information (ESI) available: NMR spectra, HPLC and HR-MS of the target compounds. See DOI: 10.1039/c6ob02507b

2017-01

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Discovery of potent and effective inhibitors containing sulfoxide structures targeting EML4-ALK rearrangement and EGFR mutant non-small cell lung cancer

Bioorganic chemistry, 2023-09, Vol.138, p.106653-106653, Article 106653

2023

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The synthesis and evaluation of new benzophenone derivatives as tubulin polymerization inhibitors

RSC advances, 2016-01, Vol.6 (91), p.88453-88462

2016

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Novel Dual-Target Kinase Inhibitors of EGFR and ALK Were Designed, Synthesized, and Induced Cell Apoptosis in Non-Small Cell Lung Cancer

A novel c-Met/TRK inhibitor 1D228 efficiently inhibits tumor growth by targeting angiogenesis and tumor cell proliferation

Synthesis and evaluation of selenium-containing indole chalcone and diarylketone derivatives as tubulin polymerization inhibition agents

Synthesis and evaluation of new 2-chloro-4-aminopyrimidine and 2,6-dimethyl-4-aminopyrimidine derivatives as tubulin polymerization inhibitors

Glucagon Enhances Chemotherapy Efficacy By Inhibition of Tumor Vessels in Colorectal Cancer

Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents

Design, synthesis, and biological evaluation of cyclic-indole derivatives as anti-tumor agents via the inhibition of tubulin polymerization

Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease

Design, synthesis, and biological evaluation of novel benzodiazepine derivatives as anticancer agents through inhibition of tubulin polymerization in vitro and in vivo

Evaluation of 4-phenylamino-substituted naphthalene-1,2-diones as tubulin polymerization inhibitors

Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFRL858R/T790M inhibitors

A Multifunctional Vanadium-Iron-Oxide Nanoparticle Eradicates Hepatocellular Carcinoma via Targeting Tumor and Endothelial Cells

Synthesis, in vitro and in vivo evaluation of new hybrids of millepachine and phenstatin as potent tubulin polymerization inhibitors

Design, synthesis, and biological evaluation of histone deacetylase inhibitors possessing glutathione peroxidase-like and antioxidant activities against Alzheimer’s disease

The synthesis and evaluation of new butadiene derivatives as tubulin polymerization inhibitors

Inhibition of TGF-β1/Smad3 signaling by compound 5aa: A potential treatment for idiopathic pulmonary fibrosis

Synthesis and Biological Evaluation of Selenium-Containing 4‑Anilinoquinazoline Derivatives as Novel Antimitotic Agents

Synthesis and evaluation of new pirfenidone derivatives as anti-fibrosis agents

Novel third-generation pyrimidines-based EGFR tyrosine kinase inhibitors targeting EGFR T790M mutation in advanced non-small cell lung cancer

The discovery of a potent and selective third-generation EGFR kinase inhibitor as a therapy for EGFR L858R/T790M double mutant non-small cell lung cancer

The new N2, N4-diphenylpyridine-2,4-diamine deuterated derivatives as EGFR inhibitors to overcome C797S-mediated resistance

Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing a sulfoxide moiety as anaplastic lymphoma kinase (ALK) inhibition agents

Synthesis, in vitro and in vivo evaluation of new hybrids of millepachine and phenstatin as potent tubulin polymerization inhibitorsElectronic supplementary information (ESI) available: NMR spectra, HPLC and HR-MS of the target compounds. See DOI: 10.1039/c6ob02507b

Discovery of potent and effective inhibitors containing sulfoxide structures targeting EML4-ALK rearrangement and EGFR mutant non-small cell lung cancer

The synthesis and evaluation of new benzophenone derivatives as tubulin polymerization inhibitors

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