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The Disposition and Metabolism of Bempedoic Acid, a Potent Inhibitor of ATP Citrate Lyase, in Healthy Human Subjects

Drug metabolism and disposition, 2023-05, Vol.51 (5), p.599-609

2023

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First-in-Human Study of AMG 820, a Monoclonal Anti-Colony-Stimulating Factor 1 Receptor Antibody, in Patients with Advanced Solid Tumors

Clinical cancer research, 2017-10, Vol.23 (19), p.5703-5710

2017

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Pharmacokinetics of bempedoic acid in patients with renal impairment

Clinical and translational science, 2022-03, Vol.15 (3), p.789-798

2022

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Phase I Study of AMG 337, a Highly Selective Small-molecule MET Inhibitor, in Patients with Advanced Solid Tumors

Clinical cancer research, 2019-04, Vol.25 (8), p.2403-2413

2019

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Population pharmacokinetic and pharmacokinetic-pharmacodynamic modeling of bempedoic acid and low-density lipoprotein cholesterol in healthy subjects and patients with dyslipidemia

Journal of pharmacokinetics and pharmacodynamics, 2023-10, Vol.50 (5), p.351-364

2023

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Absence of effect of steady state bempedoic acid on cardiac repolarization: Results of a thorough QT/QTc study in healthy volunteers

Clinical and translational science, 2021-11, Vol.14 (6), p.2487-2496

2021

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Physiologically Based Pharmacokinetic Model Development and Verification for Bioequivalence Testing of Bempedoic Acid Oral Suspension and Reference Tablet Formulation

Pharmaceutics, 2023-05, Vol.15 (5), p.1476

2023

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Phase 1, Single- and Multiple-Ascending-Dose, Food-Effect, and East Asian Subject Studies to Assess the Pharmacokinetics, Safety, and Tolerability of Bempedoic Acid, a Selective Inhibitor of Adenosine Triphosphate Citrate Lyase

Clinical pharmacology in drug development, 2023-10, Vol.12 (10), p.1022-1035

2023

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A Phase 1 study evaluating AMG 337 in Asian patients with advanced solid tumors

Japanese journal of clinical oncology, 2017-08, Vol.47 (8), p.772-776

2017

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In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models

Molecular cancer therapeutics, 2016-07, Vol.15 (7), p.1568-1579

2016

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Pharmacodynamic effect of bempedoic acid and statin combinations: predictions from a dose–response model

European heart journal. Cardiovascular pharmacotherapy, 2022-09, Vol.8 (6), p.578-586

2022

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Application of in vivo animal models to characterize the pharmacokinetic and pharmacodynamic properties of drug candidates in discovery settings

Combinatorial chemistry & high throughput screening, 2010-02, Vol.13 (2), p.207-218

2010

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Influence of Molecular Flexibility and Polar Surface Area Metrics on Oral Bioavailability in the Rat

Journal of medicinal chemistry, 2004-11, Vol.47 (24), p.6104-6107

2004

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Predicting drug absorption: how nature made it a difficult problem

The Journal of pharmacology and experimental therapeutics, 2002-12, Vol.303 (3), p.889-895

2002

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Intestinal and hepatic first-pass extraction of the 11β-HSD1 inhibitor AMG 221 in rats with chronic vascular catheters

Xenobiotica, 2014-03, Vol.44 (3), p.264-269

2014

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Abstract 9741: Pharmacokinetics, Pharmacodynamics and Safety of Bempedoic Acid in a Phase 1 Clinical Trial in Healthy Japanese, Chinese and White Subjects

Circulation (New York, N.Y.), 2021-11, Vol.144 (Suppl_1)

2021

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Pharmacokinetics, Pharmacodynamics, and Safety of Bempedoic Acid in a Phase 1 Clinical Trial in Healthy Japanese, Chinese, and White subjects

Journal of clinical lipidology, 2022-07, Vol.16 (3), p.e68-e69

2022

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Predicting the drug interaction potential of AMG 853, a dual antagonist of the D-prostanoid and chemoattractant receptor-homologous molecule expressed on T helper 2 cells receptors

Drug metabolism and disposition, 2012-12, Vol.40 (12), p.2239-2249

2012

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A phase 1, open-label, dose escalation study of AMG 337 in Asian patients (pts) with advanced solid tumors

Journal of clinical oncology, 2015-05, Vol.33 (15_suppl), p.e13538-e13538

2015

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SEA-CD40, a non-fucosylated CD40 agonist: Interim results from a phase 1 study in advanced solid tumors

Journal of clinical oncology, 2018-05, Vol.36 (15_suppl), p.3093-3093

2018

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Abstract CT137: First-in-human study of AMG 820, a monoclonal anti-CSF-1R (c-fms) antibody, in patients (pts) with advanced solid tumors

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.CT137-CT137

2016

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Abstract 3359: Translating preclinical PK/PD tumor volume modeling data to predict AMG172 PK and dose-escalation scheme in FIH

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.3359-3359

2013

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A first-in-human study of AMG 208, an oral MET inhibitor, in adult patients with advanced solid tumors

Oncotarget, 2015-07, Vol.6 (21), p.18693-18706

2015

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Clinical activity of AMG 337, an oral MET kinase inhibitor, in adult patients (pts) with MET-amplified gastroesophageal junction (GEJ), gastric (G), or esophageal (E) cancer

Journal of clinical oncology, 2015-01, Vol.33 (3_suppl), p.1-1

2015

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First-In-Human Study Of AMG 319, a Highly Selective, Small Molecule Inhibitor Of PI3Kδ, In Adult Patients With Relapsed Or Refractory Lymphoid Malignancies

Blood, 2013-11, Vol.122 (21), p.678-678

2013

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The Disposition and Metabolism of Bempedoic Acid, a Potent Inhibitor of ATP Citrate Lyase, in Healthy Human Subjects

First-in-Human Study of AMG 820, a Monoclonal Anti-Colony-Stimulating Factor 1 Receptor Antibody, in Patients with Advanced Solid Tumors

Pharmacokinetics of bempedoic acid in patients with renal impairment

Phase I Study of AMG 337, a Highly Selective Small-molecule MET Inhibitor, in Patients with Advanced Solid Tumors

Population pharmacokinetic and pharmacokinetic-pharmacodynamic modeling of bempedoic acid and low-density lipoprotein cholesterol in healthy subjects and patients with dyslipidemia

Absence of effect of steady state bempedoic acid on cardiac repolarization: Results of a thorough QT/QTc study in healthy volunteers

Physiologically Based Pharmacokinetic Model Development and Verification for Bioequivalence Testing of Bempedoic Acid Oral Suspension and Reference Tablet Formulation

Phase 1, Single- and Multiple-Ascending-Dose, Food-Effect, and East Asian Subject Studies to Assess the Pharmacokinetics, Safety, and Tolerability of Bempedoic Acid, a Selective Inhibitor of Adenosine Triphosphate Citrate Lyase

A Phase 1 study evaluating AMG 337 in Asian patients with advanced solid tumors

In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models

Pharmacodynamic effect of bempedoic acid and statin combinations: predictions from a dose–response model

Application of in vivo animal models to characterize the pharmacokinetic and pharmacodynamic properties of drug candidates in discovery settings

Influence of Molecular Flexibility and Polar Surface Area Metrics on Oral Bioavailability in the Rat

Predicting drug absorption: how nature made it a difficult problem

Intestinal and hepatic first-pass extraction of the 11β-HSD1 inhibitor AMG 221 in rats with chronic vascular catheters

Abstract 9741: Pharmacokinetics, Pharmacodynamics and Safety of Bempedoic Acid in a Phase 1 Clinical Trial in Healthy Japanese, Chinese and White Subjects

Pharmacokinetics, Pharmacodynamics, and Safety of Bempedoic Acid in a Phase 1 Clinical Trial in Healthy Japanese, Chinese, and White subjects

Predicting the drug interaction potential of AMG 853, a dual antagonist of the D-prostanoid and chemoattractant receptor-homologous molecule expressed on T helper 2 cells receptors

A phase 1, open-label, dose escalation study of AMG 337 in Asian patients (pts) with advanced solid tumors

SEA-CD40, a non-fucosylated CD40 agonist: Interim results from a phase 1 study in advanced solid tumors

Abstract CT137: First-in-human study of AMG 820, a monoclonal anti-CSF-1R (c-fms) antibody, in patients (pts) with advanced solid tumors

Abstract 3359: Translating preclinical PK/PD tumor volume modeling data to predict AMG172 PK and dose-escalation scheme in FIH

A first-in-human study of AMG 208, an oral MET inhibitor, in adult patients with advanced solid tumors

Clinical activity of AMG 337, an oral MET kinase inhibitor, in adult patients (pts) with MET-amplified gastroesophageal junction (GEJ), gastric (G), or esophageal (E) cancer

First-In-Human Study Of AMG 319, a Highly Selective, Small Molecule Inhibitor Of PI3Kδ, In Adult Patients With Relapsed Or Refractory Lymphoid Malignancies

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