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In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model

BMC biology, 2019-01, Vol.17 (1), p.4-4, Article 4

2019

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Humanizing Miniature Hearts through 4-Flow Cannulation Perfusion Decellularization and Recellularization

Scientific reports, 2018-05, Vol.8 (1), p.7458-10, Article 7458

2018

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Long noncoding RNAs are dynamically regulated during β-cell mass expansion in mouse pregnancy and control β-cell proliferation in vitro

PloS one, 2017, Vol.12 (8), p.e0182371-e0182371

2017

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1437 Renal expression pattern of the relaxin receptor, RXFP1, and effects of the RXFP1 agonist, AZD5462, on renin in non-human primates and humans

Nephrology, dialysis, transplantation, 2024-05, Vol.39 (Supplement_1)

2024

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1003 Safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple ascending doses of AZD2373, an antisense oligonucleotide targeting APOL1

Nephrology, dialysis, transplantation, 2024-05, Vol.39 (Supplement_1)

2024

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Translational strategy: humanized mini-organs

Drug discovery today, 2018-11, Vol.23 (11), p.1812-1817

2018

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Efficacy and safety of zibotentan and dapagliflozin in patients with chronic kidney disease: study design and baseline characteristics of the ZENITH-CKD trial

Nephrology, dialysis, transplantation, 2024-02, Vol.39 (3), p.414-425

2024

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Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19

Journal of molecular and cellular cardiology, 2022-06, Vol.167, p.92-96

2022

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The long noncoding RNA TUNAR modulates Wnt signaling and regulates human β-cell proliferation

American journal of physiology: endocrinology and metabolism, 2021-04, Vol.320 (4), p.E846-E857

2021

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Identification of Novel Series of Potent and Selective Relaxin Family Peptide Receptor 1 (RXFP1) Agonists

Journal of medicinal chemistry, 2024-03, Vol.67 (6), p.4442-4462

2024

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3D vascularised proximal tubules-on-a-multiplexed chip model for enhanced cell phenotypes

Lab on a chip, 2023-07, Vol.23 (14), p.3226-3237

2023

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Discovery of Clinical Candidate AZD5462, a Selective Oral Allosteric RXFP1 Agonist for Treatment of Heart Failure

Journal of medicinal chemistry, 2024-03, Vol.67 (6), p.4419-4441

2024

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Endothelin antagonism and sodium glucose Co-transporter 2 inhibition. A potential combination therapeutic strategy for COVID-19

Pulmonary pharmacology & therapeutics, 2021-08, Vol.69, p.102035-102035, Article 102035

2021

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Urine APOL1 Isoforms Reflect Plasma-Derived Liver-Synthesized Proteins

Journal of the American Society of Nephrology, 2021-10, Vol.32 (10), p.2442-2444

2021

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Abstract 347: The Success of Humanizing Miniature Hearts is the Right Cannulation

Circulation research, 2017-07, Vol.121 (suppl_1)

2017

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Patient-Centric Quantitative Microsampling for Accurate Determination of Urine Albumin to Creatinine Ratio (UACR) in a Clinical Setting

The journal of applied laboratory medicine, 2024-03, Vol.9 (2), p.329-341

2024

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Antisense oligonucleotide treatment ameliorates IFN-γ-induced proteinuria in APOL1-transgenic mice

JCI insight, 2019-06, Vol.4 (12)

2019

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Long noncoding RNAs are dynamically regulated during [beta]-cell mass expansion in mouse pregnancy and control [beta]-cell proliferation in vitro

PloS one, 2017-08, Vol.12 (8), p.e0182371

2017

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Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function

The Journal of biological chemistry, 2020-04, Vol.295 (15), p.5136-5151

2020

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Communication between the ERRα Homodimer Interface and the PGC-1α Binding Surface via the Helix 8–9 Loop

The Journal of biological chemistry, 2008-07, Vol.283 (29), p.20220-20230

2008

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Communication between the ERRalpha homodimer interface and the PGC-1alpha binding surface via the helix 8-9 loop

The Journal of biological chemistry, 2008-07, Vol.283 (29), p.20220-20230

2008

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Communication between the ERRÎ± Homodimer Interface and the PGC-1Î± Binding Surface via the Helix 8â9 Loop

The Journal of biological chemistry, 2008-07, Vol.283 (29), p.20220

2008

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Roles of Individual Amino Acids in Helix 14 of the Membrane Domain of Proton-Translocating Transhydrogenase from Escherichia coli As Deduced from Cysteine Mutagenesis

Biochemistry (Easton), 2003-06, Vol.42 (21), p.6575-6581

2003

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Properties of the apo-form of the NADP(H)-binding domain III of proton-pumping Escherichia coli transhydrogenase: implications for the reaction mechanism of the intact enzyme

Biochimica et biophysica acta, 2003-06, Vol.1604 (2), p.55-59

2003

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In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model

Humanizing Miniature Hearts through 4-Flow Cannulation Perfusion Decellularization and Recellularization

Long noncoding RNAs are dynamically regulated during β-cell mass expansion in mouse pregnancy and control β-cell proliferation in vitro

1437 Renal expression pattern of the relaxin receptor, RXFP1, and effects of the RXFP1 agonist, AZD5462, on renin in non-human primates and humans

1003 Safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple ascending doses of AZD2373, an antisense oligonucleotide targeting APOL1

Translational strategy: humanized mini-organs

Efficacy and safety of zibotentan and dapagliflozin in patients with chronic kidney disease: study design and baseline characteristics of the ZENITH-CKD trial

Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19

The long noncoding RNA TUNAR modulates Wnt signaling and regulates human β-cell proliferation

Identification of Novel Series of Potent and Selective Relaxin Family Peptide Receptor 1 (RXFP1) Agonists

3D vascularised proximal tubules-on-a-multiplexed chip model for enhanced cell phenotypes

Discovery of Clinical Candidate AZD5462, a Selective Oral Allosteric RXFP1 Agonist for Treatment of Heart Failure

Endothelin antagonism and sodium glucose Co-transporter 2 inhibition. A potential combination therapeutic strategy for COVID-19

Urine APOL1 Isoforms Reflect Plasma-Derived Liver-Synthesized Proteins

Abstract 347: The Success of Humanizing Miniature Hearts is the Right Cannulation

Patient-Centric Quantitative Microsampling for Accurate Determination of Urine Albumin to Creatinine Ratio (UACR) in a Clinical Setting

Antisense oligonucleotide treatment ameliorates IFN-γ-induced proteinuria in APOL1-transgenic mice

Long noncoding RNAs are dynamically regulated during [beta]-cell mass expansion in mouse pregnancy and control [beta]-cell proliferation in vitro

Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function

IDOL regulates systemic energy balance through control of neuronal VLDLR expression

Communication between the ERRα Homodimer Interface and the PGC-1α Binding Surface via the Helix 8–9 Loop

Communication between the ERRalpha homodimer interface and the PGC-1alpha binding surface via the helix 8-9 loop

Communication between the ERRÎ± Homodimer Interface and the PGC-1Î± Binding Surface via the Helix 8â9 Loop

Roles of Individual Amino Acids in Helix 14 of the Membrane Domain of Proton-Translocating Transhydrogenase from Escherichia coli As Deduced from Cysteine Mutagenesis

Properties of the apo-form of the NADP(H)-binding domain III of proton-pumping Escherichia coli transhydrogenase: implications for the reaction mechanism of the intact enzyme

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